ID RS4_XENLA Reviewed; 263 AA.
AC P49401; Q3B893; Q6NRW9;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=Small ribosomal subunit protein eS4 {ECO:0000305};
DE AltName: Full=40S ribosomal protein S4;
GN Name=rps4; Synonyms=rps4x;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 112-144.
RX PubMed=1579486; DOI=10.1093/nar/20.8.1859;
RA Loreni F., Francesconi A., Jappelli R., Amaldi F.;
RT "Analysis of mRNAs under translational control during Xenopus
RT embryogenesis: isolation of new ribosomal protein clones.";
RL Nucleic Acids Res. 20:1859-1863(1992).
CC -!- FUNCTION: Component of the small ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P62701}.
CC -!- SUBUNIT: Component of the small ribosomal subunit.
CC {ECO:0000250|UniProtKB:P62701}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62701}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC {ECO:0000305}.
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DR EMBL; BC070591; AAH70591.1; -; mRNA.
DR EMBL; BC106700; AAI06701.1; -; mRNA.
DR EMBL; X64206; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; S22608; S22608.
DR RefSeq; NP_001084941.1; NM_001091472.1.
DR RefSeq; NP_001090472.1; NM_001097003.1.
DR RefSeq; XP_018087661.1; XM_018232172.1.
DR PDB; 7OYC; EM; 2.40 A; E2=1-263.
DR PDBsum; 7OYC; -.
DR AlphaFoldDB; P49401; -.
DR EMDB; EMD-13113; -.
DR SMR; P49401; -.
DR BioGRID; 101364; 3.
DR IntAct; P49401; 1.
DR DNASU; 431998; -.
DR GeneID; 431998; -.
DR GeneID; 779385; -.
DR KEGG; xla:431998; -.
DR KEGG; xla:779385; -.
DR AGR; Xenbase:XB-GENE-17346803; -.
DR AGR; Xenbase:XB-GENE-967208; -.
DR CTD; 431998; -.
DR CTD; 779385; -.
DR Xenbase; XB-GENE-17346803; rps4x.L.
DR OMA; RKDYKFP; -.
DR OrthoDB; 5471107at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 431998; Expressed in testis and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd06087; KOW_RPS4; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.740; -; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR HAMAP; MF_00485; Ribosomal_eS4; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR000876; Ribosomal_eS4.
DR InterPro; IPR032277; Ribosomal_eS4_C.
DR InterPro; IPR013845; Ribosomal_eS4_central_region.
DR InterPro; IPR038237; Ribosomal_eS4_central_sf.
DR InterPro; IPR041982; Ribosomal_eS4_KOW.
DR InterPro; IPR013843; Ribosomal_eS4_N.
DR InterPro; IPR018199; Ribosomal_eS4_N_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11581; 30S/40S RIBOSOMAL PROTEIN S4; 1.
DR PANTHER; PTHR11581:SF0; 40S RIBOSOMAL PROTEIN S4; 1.
DR Pfam; PF16121; 40S_S4_C; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF00900; Ribosomal_S4e; 1.
DR Pfam; PF08071; RS4NT; 1.
DR PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR PROSITE; PS00528; RIBOSOMAL_S4E; 1.
DR PROSITE; PS50889; S4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P62701"
FT CHAIN 2..263
FT /note="Small ribosomal subunit protein eS4"
FT /id="PRO_0000130826"
FT DOMAIN 42..104
FT /note="S4 RNA-binding"
FT CONFLICT 116
FT /note="S -> A (in Ref. 1; AAH70591)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 263 AA; 29665 MW; 9AA3A805BB8146AB CRC64;
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE
VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIEKTGEHFR LVYDTKGRFA VHRITSEEAK
YKLCKVRKTW VGTKGIPHLV THDARTIRYP DPLIKVNDTI QIDLETGKIT DFIKFDTGNL
CMVTGGANLG RIGVITNRER HPGSFDVVHV KDANGNNFAT RLSNIFVIGK GNKPWISLPR
GKGIRLTIAE ERDKRLAAKQ SSG
//