ID AA1R_CHICK Reviewed; 324 AA.
AC P49892; P87469;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE RecName: Full=Adenosine receptor A1;
GN Name=ADORA1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Adipose tissue;
RX PubMed=7741703; DOI=10.1042/bj3070729;
RA Aguilar J.S., Tan F., Durand I., Green R.D.;
RT "Isolation and characterization of an avian A1 adenosine receptor gene and
RT a related cDNA clone.";
RL Biochem. J. 307:729-734(1995).
CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC mediated by G proteins which inhibit adenylyl cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U28380; AAA68977.1; -; mRNA.
DR EMBL; U28381; AAA68978.1; -; Genomic_DNA.
DR EMBL; S78192; AAB34234.1; -; mRNA.
DR EMBL; S78199; AAB34235.1; -; Genomic_DNA.
DR PIR; S55231; S55302.
DR RefSeq; NP_989647.3; NM_204316.3.
DR AlphaFoldDB; P49892; -.
DR SMR; P49892; -.
DR STRING; 9031.ENSGALP00000000223; -.
DR BindingDB; P49892; -.
DR ChEMBL; CHEMBL2114; -.
DR GlyCosmos; P49892; 1 site, No reported glycans.
DR PaxDb; 9031-ENSGALP00000000223; -.
DR Ensembl; ENSGALT00000000224; ENSGALP00000000223; ENSGALG00000000168.
DR GeneID; 374212; -.
DR KEGG; gga:374212; -.
DR CTD; 134; -.
DR VEuPathDB; HostDB:geneid_374212; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_5_1; -.
DR InParanoid; P49892; -.
DR PhylomeDB; P49892; -.
DR TreeFam; TF325296; -.
DR Reactome; R-GGA-417973; Adenosine P1 receptors.
DR Reactome; R-GGA-418594; G alpha (i) signalling events.
DR PRO; PR:P49892; -.
DR Proteomes; UP000000539; Chromosome 26.
DR Bgee; ENSGALG00000000168; Expressed in cerebellum and 4 other cell types or tissues.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0001609; F:G protein-coupled adenosine receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15071; 7tmA_Adenosine_R_A1; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001068; Adeno_A1_rcpt.
DR InterPro; IPR001634; Adenosn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24246:SF1; ADENOSINE RECEPTOR A1; 1.
DR PANTHER; PTHR24246; OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00552; ADENOSINEA1R.
DR PRINTS; PR00424; ADENOSINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Adenosine receptor A1"
FT /id="PRO_0000068995"
FT TOPO_DOM 1..10
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..33
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..146
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..201
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 309
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 80..169
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 324 AA; 36323 MW; 6FCAD801A5D3DD13 CRC64;
MAQSVTAFQA AYISIEVLIA LVSVPGNILV IWAVKMNQAL RDATFCFIVS LAVADVAVGA
LVIPLAIIIN IGPQTEFYSC LMMACPVLIL TESSILALLA IAVDRYLRVK IPVRYKSVVT
PRRAAVAIAC CWIVSFLVGL TPMFGWNNLN KVLGTRDLNV SHSEFVIKCQ FETVISMEYM
VYFNFFVWVL PPLLLMLLIY LEVFNLIRTQ LNKKVSSSSN DPQKYYGKEL KIAKSLALVL
FLFALSWLPL HILNCITLFC PSCKTPHILT YIAIFLTHGN SAMNPIVYAF RIKKFRTAFL
QIWNQYFCCK TNKSSSSSTA ETVN
//
