ID ZN138_HUMAN Reviewed; 262 AA.
AC P52744; B4DFX2; B4DP87; E9PHI7; E9PHK7;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 27-MAR-2024, entry version 186.
DE RecName: Full=Zinc finger protein 138;
GN Name=ZNF138;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANT
RP GLU-62.
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 22-260 (ISOFORM 1), AND VARIANT GLU-62.
RC TISSUE=Insulinoma;
RX PubMed=7557990; DOI=10.1006/geno.1995.1040;
RA Tommerup N., Vissing H.;
RT "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs
RT identify putative candidate genes for developmental and malignant
RT disorders.";
RL Genomics 27:259-264(1995).
CC -!- FUNCTION: May be involved in transcriptional regulation as a repressor.
CC -!- INTERACTION:
CC P52744; Q9P287: BCCIP; NbExp=3; IntAct=EBI-10746567, EBI-711154;
CC P52744; P49366: DHPS; NbExp=3; IntAct=EBI-10746567, EBI-741925;
CC P52744; Q8IYF1: ELOA2; NbExp=3; IntAct=EBI-10746567, EBI-741705;
CC P52744; P28799: GRN; NbExp=3; IntAct=EBI-10746567, EBI-747754;
CC P52744; P42858: HTT; NbExp=9; IntAct=EBI-10746567, EBI-466029;
CC P52744; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10746567, EBI-12012928;
CC P52744; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10746567, EBI-10172290;
CC P52744; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10746567, EBI-10171774;
CC P52744; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10746567, EBI-11953334;
CC P52744; Q9UPM6: LHX6; NbExp=3; IntAct=EBI-10746567, EBI-10258746;
CC P52744; P45984: MAPK9; NbExp=3; IntAct=EBI-10746567, EBI-713568;
CC P52744; Q99750: MDFI; NbExp=3; IntAct=EBI-10746567, EBI-724076;
CC P52744; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-10746567, EBI-5235340;
CC P52744; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10746567, EBI-725997;
CC P52744; O76024: WFS1; NbExp=3; IntAct=EBI-10746567, EBI-720609;
CC P52744; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-10746567, EBI-742740;
CC P52744-2; P49366: DHPS; NbExp=3; IntAct=EBI-10213071, EBI-741925;
CC P52744-2; Q6A162: KRT40; NbExp=3; IntAct=EBI-10213071, EBI-10171697;
CC P52744-2; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10213071, EBI-10171774;
CC P52744-2; Q99750: MDFI; NbExp=3; IntAct=EBI-10213071, EBI-724076;
CC P52744-2; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10213071, EBI-725997;
CC P52744-2; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-10213071, EBI-742740;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P52744-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P52744-2; Sequence=VSP_044921;
CC Name=3;
CC IsoId=P52744-3; Sequence=VSP_044921, VSP_047446, VSP_047447;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK055644; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK294302; BAG57583.1; -; mRNA.
DR EMBL; AK298230; BAG60499.1; -; mRNA.
DR EMBL; AC073349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U09847; AAC50263.1; -; mRNA.
DR CCDS; CCDS34645.2; -. [P52744-2]
DR CCDS; CCDS55115.1; -. [P52744-3]
DR PIR; I38615; I38615.
DR RefSeq; NP_001153655.1; NM_001160183.2.
DR RefSeq; NP_001258566.1; NM_001271637.1.
DR RefSeq; NP_006515.2; NM_006524.3. [P52744-2]
DR AlphaFoldDB; P52744; -.
DR SMR; P52744; -.
DR BioGRID; 113492; 18.
DR IntAct; P52744; 17.
DR iPTMnet; P52744; -.
DR PhosphoSitePlus; P52744; -.
DR BioMuta; ZNF138; -.
DR DMDM; 152031767; -.
DR jPOST; P52744; -.
DR MassIVE; P52744; -.
DR PaxDb; 9606-ENSP00000303533; -.
DR PeptideAtlas; P52744; -.
DR ProteomicsDB; 20546; -.
DR ProteomicsDB; 20561; -.
DR ProteomicsDB; 56520; -. [P52744-1]
DR Antibodypedia; 28126; 107 antibodies from 17 providers.
DR DNASU; 7697; -.
DR Ensembl; ENST00000440155.6; ENSP00000407262.2; ENSG00000197008.10. [P52744-2]
DR GeneID; 7697; -.
DR KEGG; hsa:7697; -.
DR UCSC; uc011kdq.4; human. [P52744-1]
DR AGR; HGNC:12922; -.
DR CTD; 7697; -.
DR DisGeNET; 7697; -.
DR GeneCards; ZNF138; -.
DR HGNC; HGNC:12922; ZNF138.
DR HPA; ENSG00000197008; Low tissue specificity.
DR MIM; 604080; gene.
DR neXtProt; NX_P52744; -.
DR OpenTargets; ENSG00000197008; -.
DR PharmGKB; PA37510; -.
DR VEuPathDB; HostDB:ENSG00000197008; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162960; -.
DR InParanoid; P52744; -.
DR OrthoDB; 4665594at2759; -.
DR PhylomeDB; P52744; -.
DR TreeFam; TF342117; -.
DR PathwayCommons; P52744; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P52744; -.
DR BioGRID-ORCS; 7697; 17 hits in 1107 CRISPR screens.
DR ChiTaRS; ZNF138; human.
DR GenomeRNAi; 7697; -.
DR Pharos; P52744; Tdark.
DR PRO; PR:P52744; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P52744; Protein.
DR Bgee; ENSG00000197008; Expressed in ganglionic eminence and 173 other cell types or tissues.
DR ExpressionAtlas; P52744; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24399:SF69; FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED; 1.
DR PANTHER; PTHR24399; ZINC FINGER AND BTB DOMAIN-CONTAINING; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13912; zf-C2H2_6; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..262
FT /note="Zinc finger protein 138"
FT /id="PRO_0000047422"
FT ZN_FING 110..132
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 138..160
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 166..188
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 194..216
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 222..244
FT /note="C2H2-type 5; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 250..262
FT /note="C2H2-type 6; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..12
FT /note="MKRHEMVVAKHS -> MGPLTFMDVAIEFSLEEWQCLDTAQRNVYRHVMLEN
FT YRNLVFL (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044921"
FT VAR_SEQ 13..95
FT /note="ALCSRFAQDLWLEQNIKDSFQKVTLSRYGKYGHKNLQLRKGCKSVDECKGHQ
FT GGFNGLNQCLKITTSKIFQCNKYVKVMHKFS -> DLITCLEQGKEPWNMKRHEMVVAK
FT HSAVAFTYDLSGLNILSFQSILPFVSALYVMGNRNQCLQKHLEARNKDLCVLVLPKTFG
FT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047446"
FT VAR_SEQ 96..262
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047447"
FT VARIANT 62
FT /note="G -> E (in dbSNP:rs10949946)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:7557990"
FT /id="VAR_057398"
FT CONFLICT 22..23
FT /note="LW -> KG (in Ref. 3; AAC50263)"
FT /evidence="ECO:0000305"
FT CONFLICT 67
FT /note="F -> Y (in Ref. 1; AK055644/BAG60499 and 3;
FT AAC50263)"
FT /evidence="ECO:0000305"
FT CONFLICT P52744-2:33
FT /note="M -> V (in Ref. 1; BAG60499)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 30592 MW; D2B463F0E584ACE6 CRC64;
MKRHEMVVAK HSALCSRFAQ DLWLEQNIKD SFQKVTLSRY GKYGHKNLQL RKGCKSVDEC
KGHQGGFNGL NQCLKITTSK IFQCNKYVKV MHKFSNSNRH KIRHTENKHF RCKECDKSLC
MLSRLTQHKK IHTRENFYKC EECGKTFNWS TNLSKPKKIH TGEKPYKCEV CGKAFHQSSI
LTKHKIIRTG EKPYKCAHCG KAFKQSSHLT RHKIIHTEEK PYKCEQCGKV FKQSPTLTKH
QIIYTGEEPY KCEECGKAFN LS
//
