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Database: UniProt
Entry: P55948
LinkDB: P55948
Original site: P55948 
ID   MT_CARMA                Reviewed;          58 AA.
AC   P55948;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   RecName: Full=Metallothionein;
DE            Short=MT;
OS   Carcinus maenas (Common shore crab) (Green crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata;
OC   Brachyura; Eubrachyura; Portunoidea; Carcinidae; Carcinus.
OX   NCBI_TaxID=6759;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Midgut;
RX   PubMed=8110201; DOI=10.1042/bj2970609;
RA   Pedersen K.L., Pedersen S.N., Hoejrup P., Andersen J.S.,
RA   Roepstorff P., Knudsen J., Depledge M.H.;
RT   "Purification and characterization of a cadmium-induced
RT   metallothionein from the shore crab Carcinus maenas (L.).";
RL   Biochem. J. 297:609-614(1994).
CC   -!- FUNCTION: Metallothioneins have a high content of cysteine
CC       residues that bind various heavy metals. Class I MTS in marine
CC       crustacea are involved in the sequestration of elevated levels of
CC       heavy-metal ions.
CC   -!- INDUCTION: By cadmium.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 3
CC       family. {ECO:0000305}.
DR   PIR; S43367; S43367.
DR   SMR; P55948; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002045; Metalthion_crustacean.
DR   InterPro; IPR017854; Metalthion_dom_sf.
DR   PRINTS; PR00858; MTCRUSTACEAN.
DR   SUPFAM; SSF57868; SSF57868; 2.
PE   1: Evidence at protein level;
KW   Cadmium; Direct protein sequencing; Metal-binding;
KW   Metal-thiolate cluster.
FT   CHAIN         1     58       Metallothionein.
FT                                /FTId=PRO_0000197339.
FT   REGION        1     29       Beta.
FT   REGION       30     58       Alpha.
FT   METAL         5      5       Divalent metal cation; cluster B.
FT   METAL         6      6       Divalent metal cation; cluster B.
FT   METAL        10     10       Divalent metal cation; cluster B.
FT   METAL        12     12       Divalent metal cation; cluster B.
FT   METAL        17     17       Divalent metal cation; cluster B.
FT   METAL        21     21       Divalent metal cation; cluster B.
FT   METAL        23     23       Divalent metal cation; cluster B.
FT   METAL        26     26       Divalent metal cation; cluster B.
FT   METAL        28     28       Divalent metal cation; cluster B.
FT   METAL        31     31       Divalent metal cation; cluster A.
FT   METAL        34     34       Divalent metal cation; cluster A.
FT   METAL        38     38       Divalent metal cation; cluster A.
FT   METAL        40     40       Divalent metal cation; cluster A.
FT   METAL        46     46       Divalent metal cation; cluster A.
FT   METAL        50     50       Divalent metal cation; cluster A.
FT   METAL        54     54       Divalent metal cation; cluster A.
FT   METAL        56     56       Divalent metal cation; cluster A.
FT   METAL        57     57       Divalent metal cation; cluster A.
FT   VARIANT       1      1       Missing (in variant isolated in low
FT                                cadmium concentration).
SQ   SEQUENCE   58 AA;  6133 MW;  0167CDA2E9C9731D CRC64;
     MPDPCCIDKC ECKEGGCKAG CKCTSCRCTP CEKCSSGCKC TTKEDCCKTC TKPCSCCP
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