ID TUP1_KLULA Reviewed; 682 AA.
AC P56094; Q6CKJ2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2004, sequence version 2.
DT 27-MAR-2024, entry version 141.
DE RecName: Full=General transcriptional corepressor TUP1;
GN Name=TUP1; OrderedLocusNames=KLLA0F10263g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Braun B.R., Johnson A.D.;
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [3]
RP CHARACTERIZATION.
RX PubMed=10567571; DOI=10.1128/mcb.19.12.8461;
RA Mukai Y., Matsuo E., Roth S.Y., Harashima S.;
RT "Conservation of histone binding and transcriptional repressor functions in
RT a Schizosaccharomyces pombe Tup1p homolog.";
RL Mol. Cell. Biol. 19:8461-8468(1999).
CC -!- FUNCTION: Represses transcription by RNA polymerase II.
CC -!- SIMILARITY: Belongs to the WD repeat TUP1 family. {ECO:0000305}.
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DR EMBL; AF005740; AAB63194.1; -; Genomic_DNA.
DR EMBL; CR382126; CAG98255.1; -; Genomic_DNA.
DR RefSeq; XP_455547.1; XM_455547.1.
DR AlphaFoldDB; P56094; -.
DR SMR; P56094; -.
DR STRING; 284590.P56094; -.
DR PaxDb; 284590-P56094; -.
DR GeneID; 2895005; -.
DR KEGG; kla:KLLA0_F10263g; -.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_000288_57_23_1; -.
DR InParanoid; P56094; -.
DR OMA; LTPDANW; -.
DR Proteomes; UP000000598; Chromosome F.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013890; Tscrpt_rep_Tup1_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22847:SF748; TRANSCRIPTIONAL REPRESSOR TUP11; 1.
DR PANTHER; PTHR22847; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF08581; Tup_N; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 5.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..682
FT /note="General transcriptional corepressor TUP1"
FT /id="PRO_0000051309"
FT REPEAT 319..359
FT /note="WD 1"
FT REPEAT 404..443
FT /note="WD 2"
FT REPEAT 446..485
FT /note="WD 3"
FT REPEAT 487..527
FT /note="WD 4"
FT REPEAT 537..576
FT /note="WD 5"
FT REPEAT 586..625
FT /note="WD 6"
FT REPEAT 628..673
FT /note="WD 7"
FT REGION 97..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 635
FT /note="S -> Y (in Ref. 1; AAB63194)"
FT /evidence="ECO:0000305"
FT CONFLICT 670
FT /note="S -> G (in Ref. 1; AAB63194)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 682 AA; 74008 MW; DA119FC373764466 CRC64;
MSSVAASQNK INDLLEAIRQ EFANVSQEAN SYRLQNQKDY DFKINQQLAE MQQVRNTVYE
LELTHRKMKD AYEEEISRLK LELEQKDRQL ASIAHGSTVG NVPGQVPQLS RNSGAQGNAN
IAPPNIPQPM VSQTVGTGMA PQMAPLNTQH PTQQTKSNAG EQAAANLAPV IQQQQQPQQQ
LPPQQQQQQQ QQQQSNIPVT TAAPVQPAGG NLDQTVPNSI SPQQQPTEQQ QPASTATTAP
ATASTAPPTS APSDQVGQDH YLVPADQRAV HAKPIPPFLL DLDSQLVPSH LKKQNNDYYV
LHNPALPTDL DVELHKSLEH SSVVCCVRFS SDGEFLATGC NKTTQVYKVS TGELVARLSD
DSASQPQPQP QNQTVTAETS TSNSNGSSAE DGTGNQNSAA STASSDLYIR SVCFSPDGKF
LATGAEDKLI RIWDLETKKI VMTLKGHEQD IYSLDYFPSG NKLVSGSGDR TVRIWDLTTG
TCSLTLSIED GVTTVAVSPG EGKFIAAGSL DRTVRVWDSD TGFLVERLDS ENELGTGHRD
SVYSVVFTRD GKGVVSGSLD RSVKLWNLNG LSGQKSHAEC EVTYTGHKDF VLSVATTQND
EYILSGSKDR GVLFWDTKSG NPLLMLQGHR NSVISVTVAN GHPLGPEYGV FATGSGDCKA
RIWKYSKKNS QQNSTQIKEI KE
//
