ID MUTS_RHIME Reviewed; 916 AA.
AC P56883;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=DNA mismatch repair protein MutS;
GN Name=mutS; OrderedLocusNames=R00395; ORFNames=SMc01125;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 566-916.
RX PubMed=11274131; DOI=10.1128/jb.183.8.2682-2685.2001;
RA Rudnick P.A., Arcondeguy T., Kennedy C.K., Kahn D.;
RT "glnD and mviN are genes of an essential operon in Sinorhizobium
RT meliloti.";
RL J. Bacteriol. 183:2682-2685(2001).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000305}.
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DR EMBL; AL591688; CAC41832.1; -; Genomic_DNA.
DR EMBL; AF227730; AAF37851.1; -; Genomic_DNA.
DR RefSeq; NP_384501.1; NC_003047.1.
DR RefSeq; WP_010968548.1; NC_003047.1.
DR AlphaFoldDB; P56883; -.
DR SMR; P56883; -.
DR EnsemblBacteria; CAC41832; CAC41832; SMc01125.
DR GeneID; 61601874; -.
DR KEGG; sme:SMc01125; -.
DR PATRIC; fig|266834.11.peg.1768; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_5; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..916
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115126"
FT BINDING 665..672
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 916 AA; 99182 MW; EF8651C02364D436 CRC64;
MNFLMDASNR SGDVLSVSDL ASEESRSTAT PMMEQFIEIK ANNPDSLLFY RMGDFYELFF
QDAVEASRAL GITLTKRGQH MGQEIPMCGV PVHAADDYLQ KLIASGYRVA VCEQVEDPAE
AKKRGSKSVV RRDVVRLVTP GTITEDKLLS PSESNYLMAL ARIRSGSEPA YALAWIDIST
GIFRLAETAE SRLLADILRI EPRELILPDT VFHDPDLRPV FDVLGRVAVP QPAVLFDSAT
AEGRISRYYG VGTLDGFGSF SRAELAAASA AVSYVEKTQL QERPALGIPE RESAASTLFI
DPATRANLEL AKTLSGSRDG SLLKSLDRTM TSGGARLLAE RLMSPLTDPE RINQRLDSIE
VLADQPRFTT DVRDALRRAP DMPRALSRLA LGRGGPRDLG AIQAGMRAAA AISALLSGAE
LSAELTEARD AIAALPGELL ARLDATLAEE LPLLKRDGGF VREGASAELD EMRALRDQSR
RVIAGLQLQY CEETGIKSLK IKHNNVLGYF IEVTAGNAGS MTDTDAGRAR FIHRQTMANA
MRFTTTELAE LETKIANAAD RALAIELETF EAMVREVVAE AEAIKAAALA LATIDVSAGL
AVLAEEQNYT RPTVDRSRMF AIDGGRHPVV EQALRRQAAN PFVANGCDLS PPNGEQGGAI
WLLTGPNMGG KSTFLRQNAL IAIMAQTGSF VPAAAAHIGV VDRLFSRVGA SDDLARGRST
FMVEMVETAA ILNQATDRSL VILDEIGRGT ATFDGLSIAW AAVEHLHEVN RCRGLFATHF
HELTVLSEKL VRLSNATMRV KEWDGDVIFL HEVGPGAADR SYGIQVARLA GLPASVVARA
RDVLAKLEDA DRKNPASQLI DDLPLFQVAV RREEAARASS GPSKVEEALK ALNPDDMTPR
EALDALYALK KELSNR
//
