ID LRP_RHIME Reviewed; 156 AA.
AC P56901;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=Leucine-responsive regulatory protein;
GN Name=lrp; OrderedLocusNames=R01568; ORFNames=SMc01223;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RCR2011 / SU47;
RX PubMed=11157937; DOI=10.1128/jb.183.4.1248-1258.2001;
RA Lagares A., Hozbor D.F., Niehaus K., Pich Otero A.J.L., Lorenzen J.,
RA Arnold W., Puehler A.;
RT "Genetic characterization of a Sinorhizobium meliloti chromosomal region
RT involved in lipopolysaccharide biosynthesis.";
RL J. Bacteriol. 183:1248-1258(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC affects the expression of a number of different operons; lrp mediates
CC this effect for at least some of these operons (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF193023; AAF06012.1; -; Genomic_DNA.
DR EMBL; AL591688; CAC46147.1; -; Genomic_DNA.
DR RefSeq; NP_385674.1; NC_003047.1.
DR RefSeq; WP_003529557.1; NC_003047.1.
DR AlphaFoldDB; P56901; -.
DR SMR; P56901; -.
DR EnsemblBacteria; CAC46147; CAC46147; SMc01223.
DR GeneID; 61603030; -.
DR KEGG; sme:SMc01223; -.
DR PATRIC; fig|266834.11.peg.2994; -.
DR eggNOG; COG1522; Bacteria.
DR HOGENOM; CLU_091233_0_3_5; -.
DR OrthoDB; 9811243at2; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 3.30.70.920; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30154; LEUCINE-RESPONSIVE REGULATORY PROTEIN; 1.
DR PANTHER; PTHR30154:SF34; TRANSCRIPTIONAL REGULATOR AZLB; 1.
DR Pfam; PF01037; AsnC_trans_reg; 1.
DR Pfam; PF13412; HTH_24; 1.
DR PRINTS; PR00033; HTHASNC.
DR SMART; SM00344; HTH_ASNC; 1.
DR SUPFAM; SSF54909; Dimeric alpha+beta barrel; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00519; HTH_ASNC_1; 1.
DR PROSITE; PS50956; HTH_ASNC_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..156
FT /note="Leucine-responsive regulatory protein"
FT /id="PRO_0000111734"
FT DOMAIN 7..68
FT /note="HTH asnC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT DNA_BIND 26..45
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
SQ SEQUENCE 156 AA; 17413 MW; 278285498E0903B2 CRC64;
MVVRVELDAI DMKILRELQD DGRITNVELA ERVGISAPPC LRRVRKLEEA GVIRGYRALL
NASALGYDLV AFCMVGLKHQ SDANLKAFAA RTASWPLVRE AWMVSGESDF LLQCVAENLA
SFQDFVIEEL TATENVDTVR TMLTIRQVKD ACQVEI
//
