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Database: UniProt
Entry: P58663
LinkDB: P58663
Original site: P58663 
ID   RCSB_SALTY              Reviewed;         216 AA.
AC   P58663;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 1.
DT   28-FEB-2018, entry version 106.
DE   RecName: Full=Transcriptional regulatory protein RcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN   Name=rcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN   OrderedLocusNames=STM2270;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA   Waterston R., Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT   LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. RcsB is the response regulator
CC       that binds to regulatory DNA regions. Can function both in an
CC       RcsA-dependent or RcsA-independent manner. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SUBUNIT: Interacts with RcsD and RcsA. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- PTM: Phosphorylated and activated by RcsD. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SIMILARITY: Belongs to the RcsB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
DR   EMBL; AE006468; AAL21171.1; -; Genomic_DNA.
DR   RefSeq; NP_461212.1; NC_003197.2.
DR   RefSeq; WP_001061919.1; NC_003197.2.
DR   PDB; 5O8Y; X-ray; 2.30 A; A/C/D/F/G/H=1-216.
DR   PDB; 5O8Z; X-ray; 2.10 A; A/B=1-216.
DR   PDB; 6EO2; X-ray; 2.60 A; A=1-210.
DR   PDB; 6EO3; X-ray; 2.50 A; A/B=1-210.
DR   PDBsum; 5O8Y; -.
DR   PDBsum; 5O8Z; -.
DR   PDBsum; 6EO2; -.
DR   PDBsum; 6EO3; -.
DR   ProteinModelPortal; P58663; -.
DR   SMR; P58663; -.
DR   STRING; 99287.STM2270; -.
DR   PaxDb; P58663; -.
DR   PRIDE; P58663; -.
DR   EnsemblBacteria; AAL21171; AAL21171; STM2270.
DR   GeneID; 1253792; -.
DR   KEGG; stm:STM2270; -.
DR   PATRIC; fig|99287.12.peg.2403; -.
DR   eggNOG; ENOG41068CG; Bacteria.
DR   eggNOG; COG2197; LUCA.
DR   HOGENOM; HOG000034813; -.
DR   KO; K07687; -.
DR   OMA; TITMIDN; -.
DR   PhylomeDB; P58663; -.
DR   BioCyc; SENT99287:G1FZD-2291-MONOMER; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   CDD; cd00156; REC; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00981; RcsB; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR030864; RcsB.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; DNA-binding; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    216       Transcriptional regulatory protein RcsB.
FT                                /FTId=PRO_0000081213.
FT   DOMAIN        5    124       Response regulatory.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT   DOMAIN      144    209       HTH luxR-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
FT   DNA_BIND    168    187       H-T-H motif. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
FT   MOD_RES      56     56       4-aspartylphosphate. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
FT   STRAND        4      9       {ECO:0000244|PDB:5O8Z}.
FT   HELIX        13     24       {ECO:0000244|PDB:5O8Z}.
FT   STRAND       29     37       {ECO:0000244|PDB:5O8Z}.
FT   HELIX        38     44       {ECO:0000244|PDB:5O8Z}.
FT   HELIX        45     47       {ECO:0000244|PDB:5O8Z}.
FT   STRAND       51     55       {ECO:0000244|PDB:5O8Z}.
FT   TURN         62     64       {ECO:0000244|PDB:5O8Z}.
FT   HELIX        67     77       {ECO:0000244|PDB:5O8Z}.
FT   STRAND       82     87       {ECO:0000244|PDB:5O8Z}.
FT   HELIX        92    100       {ECO:0000244|PDB:5O8Z}.
FT   STRAND      104    108       {ECO:0000244|PDB:5O8Z}.
FT   HELIX       109    111       {ECO:0000244|PDB:6EO3}.
FT   HELIX       115    125       {ECO:0000244|PDB:5O8Z}.
FT   HELIX       132    142       {ECO:0000244|PDB:5O8Z}.
FT   TURN        144    146       {ECO:0000244|PDB:5O8Y}.
FT   STRAND      147    149       {ECO:0000244|PDB:5O8Y}.
FT   HELIX       153    164       {ECO:0000244|PDB:5O8Z}.
FT   HELIX       168    173       {ECO:0000244|PDB:5O8Z}.
FT   HELIX       179    193       {ECO:0000244|PDB:5O8Z}.
FT   HELIX       198    208       {ECO:0000244|PDB:5O8Z}.
SQ   SEQUENCE   216 AA;  23715 MW;  A63D1BCF704E0680 CRC64;
     MNNMNVIIAD DHPIVLFGIR KSLEQIEWVN VVGEFEDSTA LINNLPKLDA HVLITDLSMP
     GDKYGDGITL IKYIKRHFPS LSIIVLTMNN NPAILSAVLD LDIEGIVLKQ GAPTDLPKAL
     AALQKGKKFT PESVSRLLEK ISAGGYGDKR LSPKESEVLR LFAEGFLVTE IAKKLNRSIK
     TISSQKKSAM MKLGVENDIA LLNYLSSVTL SPTDKE
//
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