ID MUTS_WOLPM Reviewed; 849 AA.
AC P61673;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=WD_0190;
OS Wolbachia pipientis wMel.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Wolbachieae; Wolbachia.
OX NCBI_TaxID=163164;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15024419; DOI=10.1371/journal.pbio.0020069;
RA Wu M., Sun L.V., Vamathevan J.J., Riegler M., DeBoy R.T., Brownlie J.C.,
RA McGraw E.A., Martin W., Esser C., Ahmadinejad N., Wiegand C., Madupu R.,
RA Beanan M.J., Brinkac L.M., Daugherty S.C., Durkin A.S., Kolonay J.F.,
RA Nelson W.C., Mohamoud Y., Lee P., Berry K.J., Young M.B., Utterback T.R.,
RA Weidman J.F., Nierman W.C., Paulsen I.T., Nelson K.E., Tettelin H.,
RA O'Neill S.L., Eisen J.A.;
RT "Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a
RT streamlined genome overrun by mobile genetic elements.";
RL PLoS Biol. 2:327-341(2004).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS13936.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE017196; AAS13936.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; P61673; -.
DR SMR; P61673; -.
DR EnsemblBacteria; AAS13936; AAS13936; WD_0190.
DR KEGG; wol:WD_0190; -.
DR eggNOG; COG0249; Bacteria.
DR Proteomes; UP000008215; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..849
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000115168"
FT BINDING 665..672
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 849 AA; 95281 MW; 3A4EB5E35AE5B9FD CRC64;
MCNIIYNNVY QYNILKNIMS FVKEKNTPVM EQYLNLKAQY KDHLLFYRLG DFYELFFDDA
IKAAKLLNIV LTKRGNSCGQ EIPMCGVPAH SSESYLHKLI DLGFKVAICD QLETADEAKK
RGYKSIVKRD VVRVVTPGTI IEDSLLEDKS NNYLASIVEQ NDEYAISWLE LSTGKFFHTL
TSLKALDSDL LRISPRELLI SEKFTEDEKI RSILKNYKIS ITQHAQSFFE YSKSHRTLCE
FYKIRELGSI GNFSKVEIMA CGALLEYVRV TQRGSIPRLE FPKTYKQQNF MLIDTSARRN
LELFSTQFGE KKGSLISVID HTVTASGGRL LKQMLASPLA CSKAINLRLS TAQFFVNNHD
SRRKIREILS NIPDIERSLS RLILGRGSPK DMNLLKIGLG KTLELSEFLC KIESGENGSL
PQQYVIQTEI QPASRAGITV KSDESELSTI HKSLGNHKDL FELLNSAILD NNLSSVKEGG
FIHSKYNSEL SELSYILNNS NKLVTKLRES YRDLTGIAAL KILHNNILGY YVEVSANHKI
TSDIFIHRQS LANSMRYTTN ELKELENKIL TARDAAIGLE MKIFSELCSE VAKESEKIAL
AANALAKLDI RTAFAELAVQ NNYVKPIIDD SKEFNICSGR HPVVEVNDKF IANSINLAGI
HLITGPNMAG KSTFLRQNAL IAILAHMGSF VPAESAHIGV IDKIFSRVGA TDNITAGYST
FMVEMIETAT IVNQATDRSL VILDEIGRGT GVYDGLSIAQ AVIEHIHNVN KCRAIFATHY
HELTKVSKYL KNVKCFCVKI REWNGEVIFL HEVIEGIADE SYGIHVAKLA GFPDSVLNRA
SEVFEELKA
//
