ID   B2MG_AOTNA              Reviewed;         119 AA.
AC   P63064; O46570;
DT   13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   24-JAN-2024, entry version 73.
DE   RecName: Full=Beta-2-microglobulin;
DE   Flags: Precursor;
GN   Name=B2M;
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC   TISSUE=Blood;
RX   PubMed=10079295; DOI=10.1007/s002510050498;
RA   Ladasky J.J., Shum B.P., Canavez F., Seuanez H.N., Parham P.;
RT   "Residue 3 of beta2-microglobulin affects binding of class I MHC molecules
RT   by the W6/32 antibody.";
RL   Immunogenetics 49:312-320(1999).
CC   -!- FUNCTION: Component of the class I major histocompatibility complex
CC       (MHC). Involved in the presentation of peptide antigens to the immune
CC       system.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2-
CC       microglobulin is the beta-chain of major histocompatibility complex
CC       class I molecules.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the beta-2-microglobulin family. {ECO:0000305}.
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DR   EMBL; AF042144; AAB97463.1; -; mRNA.
DR   EMBL; AF042145; AAB97464.1; -; mRNA.
DR   RefSeq; NP_001295445.1; NM_001308516.1.
DR   AlphaFoldDB; P63064; -.
DR   SMR; P63064; -.
DR   STRING; 37293.ENSANAP00000029531; -.
DR   Ensembl; ENSANAT00000047556.1; ENSANAP00000029526.1; ENSANAG00000032555.1.
DR   GeneID; 105710084; -.
DR   CTD; 567; -.
DR   GeneTree; ENSGT00690000102227; -.
DR   OMA; CRVAHST; -.
DR   OrthoDB; 4629494at2759; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd05770; IgC1_beta2m; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR015707; B2Microglobulin.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   PANTHER; PTHR19944:SF62; BETA-2-MICROGLOBULIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Immunity; Immunoglobulin domain; MHC I; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..119
FT                   /note="Beta-2-microglobulin"
FT                   /id="PRO_0000018754"
FT   DOMAIN          25..114
FT                   /note="Ig-like C1-type"
FT   DISULFID        45..100
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   119 AA;  13693 MW;  1D9555C59ED8F15D CRC64;
     MARFVVVALL VLLSLSGLEA IQHAPKIQVY SRHPAENGKP NFLNCYVSGF HPSDIEVDLL
     KNGKKIEKVE HSDLSFSKDW SFYLLYYTEF TPNEKDEYAC RVSHVTLSTP KTVKWDRNM
//