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Database: UniProt
Entry: P64321
LinkDB: P64321
Original site: P64321 
ID   UVRD2_MYCBO             Reviewed;         700 AA.
AC   P64321; A0A1R3Y3E9; O53344; X2BMV8;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   05-DEC-2018, entry version 89.
DE   RecName: Full=ATP-dependent DNA helicase UvrD2;
DE            EC=3.6.4.12;
GN   Name=uvrD2; OrderedLocusNames=BQ2027_MB3222C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H.,
RA   Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S.,
RA   Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R.,
RA   Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
RP   REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomeA.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium
RT   bovis AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: DNA-dependent ATPase, stimulated equally by ss-and
CC       dsDNA. Has both ATPase and helicase activities (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000305}.
DR   EMBL; LT708304; SIU01850.1; -; Genomic_DNA.
DR   RefSeq; NP_856867.1; NC_002945.3.
DR   RefSeq; WP_003416822.1; NC_002945.4.
DR   ProteinModelPortal; P64321; -.
DR   SMR; P64321; -.
DR   PRIDE; P64321; -.
DR   EnsemblBacteria; CDO44494; CDO44494; Mb3222c.
DR   PATRIC; fig|233413.5.peg.3548; -.
DR   HOGENOM; HOG000033018; -.
DR   OMA; LLLYWAQ; -.
DR   BioCyc; MBOV233413:G1GT4-3390-MONOMER; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.160; -; 1.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 2.
DR   Pfam; PF00570; HRDC; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; SSF47819; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50967; HRDC; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding;
KW   Helicase; Hydrolase; Nucleotide-binding.
FT   CHAIN         1    700       ATP-dependent DNA helicase UvrD2.
FT                                /FTId=PRO_0000102080.
FT   DOMAIN       10    301       UvrD-like helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00560}.
FT   DOMAIN      302    553       UvrD-like helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00617}.
FT   DOMAIN      626    700       HRDC. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00328}.
FT   NP_BIND      34     39       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00560}.
FT   BINDING     299    299       ATP. {ECO:0000250}.
SQ   SEQUENCE   700 AA;  75604 MW;  60A1B7520855C81C CRC64;
     MSIASDPLIA GLDDQQREAV LAPRGPVCVL AGAGTGKTRT ITHRIASLVA SGHVAAGQVL
     AVTFTQRAAG EMRSRLRALD AAARTGSGVG AVQALTFHAA AYRQLRYFWS RVIADTGWQL
     LDSKFAVVAR AASRTRLHAS TDDVRDLAGE IEWAKASLIG PEEYVTAVAA ARRDPPLDAA
     QIAAVYSEYE ALKARGDGVT LLDFDDLLLH TAAAIENDAA VAEEFQDRYR CFVVDEYQDV
     TPLQQRVLSA WLGDRDDLTV VGDANQTIYS FTGASPRFLL DFSRRFPDAA VVRLERDYRS
     TPQVVSLANR VIAAARGRVA GSKLRLSGQR EPGPVPSFHE HSDEPAEAAT VAASIARLIA
     SGTPPSEVAI LYRVNAQSEV YEEALTQAGI AYQVRGGEGF FNRQEIKQAL LALQRVSERD
     TDAALSDVVR AVLAPLGLTA QPPVGTRARE RWEALTALAE LVDDELAQRP ALQLPGLLAE
     LRRRAEARHP PVVQGVTLAS LHAAKGLEWD AVFLVGLADG TLPISHALAH GPNSEPVEEE
     RRLLYVGITR ARVHLALSWA LSRSPGGRQS RKPSRFLNGI APQTRADPVP GTSRRNRGAA
     ARCRICNNEL NTSAAVMLRR CETCAADVDE ELLLQLKSWR LSTAKEQNVP AYVVFTDNTL
     IAIAELLPTD DAALIAIPGI GARKLEQYGS DVLQLVRGRT
//
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