ID BAER_ECOL6 Reviewed; 240 AA.
AC P69229; P30846;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Transcriptional regulatory protein BaeR;
GN Name=baeR; OrderedLocusNames=c2605;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Member of the two-component regulatory system BaeS/BaeR.
CC Activates the mdtABCD operon (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- PTM: Phosphorylated by BaeS. {ECO:0000250}.
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DR EMBL; AE014075; AAN81061.1; -; Genomic_DNA.
DR RefSeq; WP_000137877.1; NZ_CP051263.1.
DR PDB; 4B09; X-ray; 3.30 A; A/B/C/D/E/F/G/H/I/J/K/L=1-240.
DR PDBsum; 4B09; -.
DR AlphaFoldDB; P69229; -.
DR SMR; P69229; -.
DR STRING; 199310.c2605; -.
DR GeneID; 75056798; -.
DR KEGG; ecc:c2605; -.
DR eggNOG; COG0745; Bacteria.
DR HOGENOM; CLU_000445_30_4_6; -.
DR BioCyc; ECOL199310:C2605-MONOMER; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd19938; REC_OmpR_BaeR-like; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.250.690; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; REGULATOR OF RPOS; 1.
DR PANTHER; PTHR48111:SF59; TRANSCRIPTIONAL REGULATORY PROTEIN BAER; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..240
FT /note="Transcriptional regulatory protein BaeR"
FT /id="PRO_0000081022"
FT DOMAIN 12..125
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 131..234
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 61
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT STRAND 12..16
FT /evidence="ECO:0007829|PDB:4B09"
FT HELIX 20..32
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 36..40
FT /evidence="ECO:0007829|PDB:4B09"
FT HELIX 46..52
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 56..61
FT /evidence="ECO:0007829|PDB:4B09"
FT HELIX 68..79
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 84..87
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 104..108
FT /evidence="ECO:0007829|PDB:4B09"
FT HELIX 114..124
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 143..146
FT /evidence="ECO:0007829|PDB:4B09"
FT TURN 147..150
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 151..154
FT /evidence="ECO:0007829|PDB:4B09"
FT HELIX 163..174
FT /evidence="ECO:0007829|PDB:4B09"
FT HELIX 182..191
FT /evidence="ECO:0007829|PDB:4B09"
FT HELIX 201..215
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 217..219
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 222..225
FT /evidence="ECO:0007829|PDB:4B09"
FT TURN 226..228
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 229..232
FT /evidence="ECO:0007829|PDB:4B09"
FT STRAND 238..240
FT /evidence="ECO:0007829|PDB:4B09"
SQ SEQUENCE 240 AA; 27656 MW; 8E2F6C9EB911C9CC CRC64;
MTELPIDENT PRILIVEDEP KLGQLLIDYL RAASYAPTLI SHGDQVLPYV RQTPPDLILL
DLMLPGTDGL TLCREIRRFS DIPIVMVTAK IEEIDRLLGL EIGADDYICK PYSPREVVAR
VKTILRRCKP QRELQQQDAE SPLIIDEGRF QASWRGKMLD LTPAEFRLLK TLSHEPGKVF
SREQLLNHLY DDYRVVTDRT IDSHIKNLRR KLESLDAEQS FIRAVYGVGY RWEADACRIV
//
