GenomeNet

Database: UniProt
Entry: P72689
LinkDB: P72689
Original site: P72689 
ID   IF2_SYNY3               Reviewed;        1001 AA.
AC   P72689;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   10-APR-2019, entry version 132.
DE   RecName: Full=Translation initiation factor IF-2;
GN   Name=infB; OrderedLocusNames=slr0744;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae;
OC   Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T.,
RA   Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S.,
RA   Shimpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M.,
RA   Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the
RT   entire genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: One of the essential components for the initiation of
CC       protein synthesis. Protects formylmethionyl-tRNA from spontaneous
CC       hydrolysis and promotes its binding to the 30S ribosomal subunits.
CC       Also involved in the hydrolysis of GTP during the formation of the
CC       70S ribosomal complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2
CC       subfamily. {ECO:0000305}.
DR   EMBL; BA000022; BAA16696.1; -; Genomic_DNA.
DR   PIR; S74544; S74544.
DR   ProteinModelPortal; P72689; -.
DR   SMR; P72689; -.
DR   IntAct; P72689; 4.
DR   STRING; 1148.1651769; -.
DR   PaxDb; P72689; -.
DR   PRIDE; P72689; -.
DR   EnsemblBacteria; BAA16696; BAA16696; BAA16696.
DR   KEGG; syn:slr0744; -.
DR   HOGENOM; HOG000076906; -.
DR   InParanoid; P72689; -.
DR   KO; K02519; -.
DR   OMA; NIAVKSH; -.
DR   PhylomeDB; P72689; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   Gene3D; 3.40.50.10050; -; 1.
DR   HAMAP; MF_00100_B; IF_2_B; 1.
DR   InterPro; IPR006847; IF2_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; TF_GTP-bd_dom.
DR   InterPro; IPR000178; TF_IF2_bacterial-like.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   PANTHER; PTHR43381; PTHR43381; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   Pfam; PF04760; IF2_N; 2.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 2.
DR   SUPFAM; SSF52156; SSF52156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00487; IF-2; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
DR   PROSITE; PS01176; IF2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; GTP-binding; Initiation factor;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN         1   1001       Translation initiation factor IF-2.
FT                                /FTId=PRO_0000137269.
FT   DOMAIN      493    666       tr-type G.
FT   NP_BIND     502    509       GTP. {ECO:0000250}.
FT   NP_BIND     552    556       GTP. {ECO:0000250}.
FT   NP_BIND     606    609       GTP. {ECO:0000250}.
FT   REGION      502    509       G1. {ECO:0000250}.
FT   REGION      527    531       G2. {ECO:0000250}.
FT   REGION      552    555       G3. {ECO:0000250}.
FT   REGION      606    609       G4. {ECO:0000250}.
FT   REGION      642    644       G5. {ECO:0000250}.
SQ   SEQUENCE   1001 AA;  108119 MW;  4C7F00DEE56CE31C CRC64;
     MNNAKVRIYD LSKELNLENR DILDICERLN VAAKSHSSTI SESDAERIKA AAEKFTPQQP
     KKPRVASRPE SKEDKSDPKQ QKILAIHHKQ EKSGGPSPAR PTPPPRPKLQ APKAPTPPQP
     PVAKASAPKI QKQEEPAQEA PKSVAPPTQP LAPPPVPSLQ SPPSKPAPPT PPAKKAAPAP
     RLAGPPGRTA SPNKTAVPAP AKPKVNRPEI VSLKDNRGQA RSPGDREEKV AIAAPEPPKP
     KVELRRPKPP RPEEDENLPE LLEFPPLSRG KGVDGDNDAD DGDLLSTEKP KPKLKRPTPP
     RLGKPDQWED DEDEKANKAK AANKGKRRPK MDDDDDDLDI DGDNGPKPTL VSLSIARPPK
     PKSLAAKPST PTVAKVKKPT LKSEAGSSAG GSSRSRGDRR DRKEVVQKPE VIMLDRSLTV
     RDLADLLKIS ETDIIKRLFL KGVAVQITQT LDEETARMVA ESFEVAVETP ERVAAAAKTT
     EMLDEADLDN LVRRPPVVTI MGHVDHGKTT LLDSIRKTKV AQGEAGGITQ HIGAYHVEVE
     HNDKTEQIVF LDTPGHEAFT AMRARGAKVT DIAILVVAAD DGVQPQTKEA ISHAKAAGVP
     LIVAINKVDK PEANPDRIKQ ELSELGLLAE EWGGDTIMVP VSALNGDNLD GLLEMILLVS
     EVEELVANPN RQAKGTVIEA NLDRTRGPVA TLLIQNGTLR VGDAIVVGAV YGKIRAMIDD
     RGDKVEEASP SFAVEILGLG DVPAAGDEFE VFTNEKDARL QAEARAMEDR QTRLQQAMSS
     RKVTLSSISA QAQEGELKEL NIILKADVQG SLGAILGSLE QLPQGEVQIR VLLASPGEVT
     ETDVDLAAAS GAIIIGFNTT LASGARQAAD QEGVDIREYD IIYKLLDDIQ GAMEGLLDPE
     EIESSLGTAE VRAVFPVGRG NIAGCYVQSG KIIRNRNLRV RRGDQVLFEG NIDSLKRIKE
     DVREVNAGYE CGIGCSKFND WKEGDIIEAY EMTMKRRTLA T
//
DBGET integrated database retrieval system