ID HMUV_YEREN Reviewed; 266 AA.
AC P74981;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 2.
DT 03-MAY-2023, entry version 111.
DE RecName: Full=Hemin import ATP-binding protein HmuV {ECO:0000255|HAMAP-Rule:MF_01718};
DE EC=7.6.2.- {ECO:0000255|HAMAP-Rule:MF_01718};
GN Name=hmuV {ECO:0000255|HAMAP-Rule:MF_01718}; Synonyms=hemV;
OS Yersinia enterocolitica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=630;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION IN HEMIN TRANSPORT.
RC STRAIN=ATCC 51872 / WA-C / Serotype O:8;
RX PubMed=7997183; DOI=10.1111/j.1365-2958.1994.tb00465.x;
RA Stojiljkovic I., Hantke K.;
RT "Transport of haemin across the cytoplasmic membrane through a haemin-
RT specific periplasmic binding-protein-dependent transport system in Yersinia
RT enterocolitica.";
RL Mol. Microbiol. 13:719-732(1994).
CC -!- FUNCTION: Part of the ABC transporter complex HmuTUV involved in hemin
CC import. Responsible for energy coupling to the transport system
CC (Probable). {ECO:0000305|PubMed:7997183}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HmuV),
CC two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).
CC {ECO:0000255|HAMAP-Rule:MF_01718}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01718}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01718}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Heme (hemin)
CC importer (TC 3.A.1.14.5) family. {ECO:0000255|HAMAP-Rule:MF_01718}.
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DR EMBL; X77867; CAA54864.1; -; Genomic_DNA.
DR PIR; S54440; S54440.
DR RefSeq; WP_005175609.1; NZ_NWMR01000018.1.
DR AlphaFoldDB; P74981; -.
DR SMR; P74981; -.
DR STRING; 1443113.LC20_04861; -.
DR eggNOG; COG4559; Bacteria.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03214; ABC_Iron-Siderophores_B12_Hemin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR42794; HEMIN IMPORT ATP-BINDING PROTEIN HMUV; 1.
DR PANTHER; PTHR42794:SF1; HEMIN IMPORT ATP-BINDING PROTEIN HMUV; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51261; HMUV; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Translocase; Transport.
FT CHAIN 1..266
FT /note="Hemin import ATP-binding protein HmuV"
FT /id="PRO_0000269640"
FT DOMAIN 12..248
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01718"
FT BINDING 44..51
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01718"
SQ SEQUENCE 266 AA; 29495 MW; 7F606FF07A126BEE CRC64;
MVDTAVVDTA LLEANQLSYH VQGQKLINNV SLQIASGEMV AIIGPNGAGK STLLRLLTGY
LAPSEGHCQL LGKNLNSWQP QALARTRAVM RQYSDLAFPF SVSEVIQMGR APYGAAQNRQ
ALQEVMAQTD CLALAQRDYR ALSGGEQQRV QLARVLAQLW QPEPTSRWLF LDEPTSALDL
YHQQHTLRLL RQLTLEEPLA VCCVLHDLNL AALYADRILL LAQGELVACG TPEEVLNAET
LTRWYQADLG ISRHPESALP QIYLRQ
//
