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Database: UniProt
Entry: P75172
LinkDB: P75172
Original site: P75172 
ID   Y623_MYCPN              Reviewed;         450 AA.
AC   P75172;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   11-DEC-2019, entry version 108.
DE   RecName: Full=Probable ATP-dependent RNA helicase MG425 homolog;
DE            EC=3.6.4.13;
GN   OrderedLocusNames=MPN_623; ORFNames=C12_orf450, MP219;
OS   Mycoplasma pneumoniae (strain ATCC 29342 / M129).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272634;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29342 / M129;
RX   PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA   Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT   "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT   pneumoniae.";
RL   Nucleic Acids Res. 24:4420-4449(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. {ECO:0000305}.
DR   EMBL; U00089; AAB95867.1; -; Genomic_DNA.
DR   PIR; S73545; S73545.
DR   RefSeq; NP_110312.1; NC_000912.1.
DR   RefSeq; WP_010874980.1; NC_000912.1.
DR   SMR; P75172; -.
DR   IntAct; P75172; 3.
DR   EnsemblBacteria; AAB95867; AAB95867; MPN_623.
DR   GeneID; 877188; -.
DR   KEGG; mpn:MPN623; -.
DR   PATRIC; fig|272634.6.peg.687; -.
DR   OMA; KAKNRSI; -.
DR   BioCyc; MPNE272634:G1GJ3-1003-MONOMER; -.
DR   Proteomes; UP000000808; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..450
FT                   /note="Probable ATP-dependent RNA helicase MG425 homolog"
FT                   /id="PRO_0000055115"
FT   DOMAIN          34..206
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          234..384
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   NP_BIND         47..54
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   MOTIF           3..31
FT                   /note="Q motif"
FT   MOTIF           154..157
FT                   /note="DEVD box"
SQ   SEQUENCE   450 AA;  51245 MW;  4CEBA56788821185 CRC64;
     MDSTFNELGV SPALIATLKD NNINQPTTIQ QLAIPQFLQH QNLIVHSPTG TGKTAVFGIP
     VIETLLKKPS KGTTQTLVVA PTRELAEQIK TTFINFAKHT HLKVVSLIGG IPIWQQLKQL
     ENQPEIVVGT MGRVMDLLER GVIKFEHLEH LIIDEVDLML DRGFKRKLFD LLSRIEKFEQ
     IAVYSASYNE ETIETAKQIT KNGIFLAAPE LKQNAPEPDN KLIDQFVCYL FSNRKKQALY
     SLVSQTRAKS IIVFCDTKKL VDELCIFLRK NDVKTYPLHG DKAQFIRERN LKLFANTTAP
     IVLVTTDLIG RGIHVEGVDM VVNYSACVNF ETYLHRMGRT GRNNHKGSCI TFCTSHEKQA
     FLKLLEQVND KRISPLRPMR LRLIPLKCKT QPKKGKLSLQ SVQKIYVNPR SNGTFKRVPL
     AGDLFKSRMR QPERDMQKNK LHDSDWQSNM
//
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