ID Y292_MYCPN Reviewed; 309 AA.
AC P75485;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Uncharacterized RNA pseudouridine synthase MG209 homolog;
DE EC=5.4.99.-;
DE AltName: Full=RNA pseudouridylate synthase;
DE AltName: Full=RNA-uridine isomerase;
GN OrderedLocusNames=MPN_292; ORFNames=H10_orf309, MP543;
OS Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
OS (Mycoplasmoides pneumoniae).
OC Bacteria; Mycoplasmatota; Mycoplasmoidales; Mycoplasmoidaceae;
OC Mycoplasmoides.
OX NCBI_TaxID=272634;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129 / Subtype 1;
RX PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
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DR EMBL; U00089; AAB96191.1; -; Genomic_DNA.
DR PIR; S73869; S73869.
DR RefSeq; NP_109980.1; NC_000912.1.
DR RefSeq; WP_010874649.1; NZ_OU342337.1.
DR AlphaFoldDB; P75485; -.
DR SMR; P75485; -.
DR IntAct; P75485; 4.
DR STRING; 272634.MPN_292; -.
DR EnsemblBacteria; AAB96191; AAB96191; MPN_292.
DR KEGG; mpn:MPN_292; -.
DR PATRIC; fig|272634.6.peg.316; -.
DR HOGENOM; CLU_016902_4_4_14; -.
DR OrthoDB; 9807829at2; -.
DR BioCyc; MPNE272634:G1GJ3-460-MONOMER; -.
DR Proteomes; UP000000808; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR NCBIfam; TIGR00005; rluA_subfam; 1.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF44; PSEUDOU_SYNTH_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Isomerase; Reference proteome; RNA-binding.
FT CHAIN 1..309
FT /note="Uncharacterized RNA pseudouridine synthase MG209
FT homolog"
FT /id="PRO_0000162740"
FT DOMAIN 11..87
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT ACT_SITE 131
FT /evidence="ECO:0000250"
SQ SEQUENCE 309 AA; 35229 MW; 7F2D8135F9C75A40 CRC64;
MEQTFSVTTA QRLDTFLATL LNLSRVKVAK LIVDGLVSVN GKKITKNGWL VQPEDRVHVN
WSEELFEKVP VEVQPYDFPL DILYEDEQIM VVNKPNGLIS HPTSFNESES LLGAALFHCN
HQPVFLVHRL DRDTSGVIML AKNQSSLLHL QKQLQQRVMK RYYLALVHFP LDSLSGTISA
PLERVGNNKV MWKVGNSSNK AKNAFTKFTV LNQNEKAALI KCELLTGRTH QIRVHLQFIK
HPVYNDPLYG LKSEQATEYG QYLHAQQISF IHPTLNKEMG FEAQLDKTFS DKLDNLNLKI
ANSLYALFQ
//
