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Database: UniProt
Entry: P79881
LinkDB: P79881
Original site: P79881 
ID   GUC1B_CHICK             Reviewed;         198 AA.
AC   P79881;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   24-JAN-2024, entry version 147.
DE   RecName: Full=Guanylyl cyclase-activating protein 2;
DE            Short=GCAP 2;
DE   AltName: Full=Guanylate cyclase activator 1B;
GN   Name=GUCA1B; Synonyms=GCAP2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=8641465; DOI=10.1016/0014-5793(96)00345-6;
RA   Semple-Rowland S.L., Gorczyca W.A., Buczylko J., Helekar B.S., Ruiz C.C.,
RA   Subbaraya I., Palczewski K., Baehr W.;
RT   "Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant
RT   chicken retina.";
RL   FEBS Lett. 385:47-52(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC   STRAIN=White leghorn; TISSUE=Liver;
RX   PubMed=10427104;
RA   Semple-Rowland S.L., Larkin P., Bronson J.D., Nykamp K., Streit W.J.,
RA   Baehr W.;
RT   "Characterization of the chicken GCAP gene array and analyses of GCAP1,
RT   GCAP2, and GC1 gene expression in normal and rd chicken pineal.";
RL   Mol. Vis. 5:14-14(1999).
CC   -!- FUNCTION: Stimulates synthesis of cGMP in photoreceptors. Thought to
CC       mediate Ca(2+)-sensitive regulation of retinal guanylyl cyclase (GC), a
CC       key event in recovery of the dark state of rod photoreceptors following
CC       light exposure (By similarity). {ECO:0000250|UniProtKB:P51177}.
CC   -!- SUBUNIT: Undergoes dimerization at low calcium ions concentration,
CC       while the presence of calcium ions inhibits its dimerization.
CC       Dimerization correlates with its ability to activate GC.
CC   -!- TISSUE SPECIFICITY: Retina and pineal gland.
CC       {ECO:0000269|PubMed:10427104}.
CC   -!- MISCELLANEOUS: Binds three calcium ions. {ECO:0000250}.
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DR   EMBL; S82200; AAB47112.1; -; mRNA.
DR   EMBL; AF172708; AAD47880.1; -; Genomic_DNA.
DR   PIR; S68839; S68839.
DR   RefSeq; NP_001007882.1; NM_001007881.2.
DR   AlphaFoldDB; P79881; -.
DR   SMR; P79881; -.
DR   STRING; 9031.ENSGALP00000034499; -.
DR   PaxDb; 9031-ENSGALP00000034499; -.
DR   Ensembl; ENSGALT00000090927; ENSGALP00000069354; ENSGALG00000001418.
DR   Ensembl; ENSGALT00010065998.1; ENSGALP00010040264.1; ENSGALG00010027222.1.
DR   Ensembl; ENSGALT00015051296; ENSGALP00015029605; ENSGALG00015021049.
DR   GeneID; 419864; -.
DR   KEGG; gga:419864; -.
DR   CTD; 2979; -.
DR   VEuPathDB; HostDB:geneid_419864; -.
DR   eggNOG; KOG0044; Eukaryota.
DR   GeneTree; ENSGT00940000157530; -.
DR   HOGENOM; CLU_072366_4_0_1; -.
DR   InParanoid; P79881; -.
DR   OMA; LRWTFKI; -.
DR   OrthoDB; 339700at2759; -.
DR   PhylomeDB; P79881; -.
DR   TreeFam; TF333971; -.
DR   Reactome; R-GGA-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR   PRO; PR:P79881; -.
DR   Proteomes; UP000000539; Chromosome 26.
DR   Bgee; ENSGALG00000001418; Expressed in testis and 2 other cell types or tissues.
DR   ExpressionAtlas; P79881; baseline.
DR   GO; GO:0120199; C:cone photoreceptor outer segment; IBA:GO_Central.
DR   GO; GO:0001917; C:photoreceptor inner segment; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0008048; F:calcium sensitive guanylate cyclase activator activity; IBA:GO_Central.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IBA:GO_Central.
DR   CDD; cd00051; EFh; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR028846; Recoverin.
DR   PANTHER; PTHR23055; CALCIUM BINDING PROTEINS; 1.
DR   PANTHER; PTHR23055:SF11; GUANYLYL CYCLASE-ACTIVATING PROTEIN 2; 1.
DR   Pfam; PF00036; EF-hand_1; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   PRINTS; PR00450; RECOVERIN.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 3.
DR   PROSITE; PS50222; EF_HAND_2; 3.
PE   2: Evidence at transcript level;
KW   Calcium; Lipoprotein; Metal-binding; Myristate; Reference proteome; Repeat;
KW   Sensory transduction; Vision.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000255"
FT   CHAIN           2..198
FT                   /note="Guanylyl cyclase-activating protein 2"
FT                   /id="PRO_0000073810"
FT   DOMAIN          16..51
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          52..87
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          88..123
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          139..174
FT                   /note="EF-hand 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         65
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         67
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         69
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         71
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         76
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         101
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         103
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         105
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         107
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         112
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         152
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         154
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         156
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         158
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         163
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  23128 MW;  7A2B475FCD34964F CRC64;
     MGQQFTNAEG EQTEIDVAEL QEWYKKFVVE CPSGTLFMHE FKRFFGVQDN HEAAEYIENM
     FRAFDKNGDN TIDFLEYVAA LNLVLRGKLE HKLRWTFKVY DKDGNGCIDK PELLEIVESI
     YKLKKVCRSE VEERTPLLTP EEVVDRIFQL VDENGDGQLS LDEFIDGARK DKWVMKMLQM
     DVNPGGWISE QRRKSALF
//
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