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Database: UniProt
Entry: P80477
LinkDB: P80477
Original site: P80477 
ID   SDHB_PORPU              Reviewed;         239 AA.
AC   P80477;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   05-DEC-2018, entry version 96.
DE   RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit;
DE            EC=1.3.5.1;
DE   AltName: Full=Iron-sulfur subunit of complex II;
DE            Short=Ip;
GN   Name=SDH2; Synonyms=SDHB;
OS   Porphyra purpurea (Red seaweed) (Ulva purpurea).
OG   Mitochondrion.
OC   Eukaryota; Rhodophyta; Bangiophyceae; Bangiales; Bangiaceae; Porphyra.
OX   NCBI_TaxID=2787;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8637872; DOI=10.1073/pnas.93.6.2328;
RA   Burger G., Lang B.F., Reith M., Gray M.W.;
RT   "Genes encoding the same three subunits of respiratory complex II are
RT   present in the mitochondrial DNA of two phylogenetically distant
RT   eukaryotes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996).
CC   -!- FUNCTION: Iron-sulfur protein (IP) subunit of succinate
CC       dehydrogenase (SDH) that is involved in complex II of the
CC       mitochondrial electron transport chain and is responsible for
CC       transferring electrons from succinate to ubiquinone (coenzyme Q).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + succinate = a quinol + fumarate;
CC         Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1;
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [3Fe-4S] cluster. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       fumarate from succinate (eukaryal route): step 1/1.
CC   -!- SUBUNIT: Component of complex II composed of four subunits: a
CC       flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b
CC       composed of a large and a small subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the succinate dehydrogenase/fumarate
CC       reductase iron-sulfur protein family. {ECO:0000305}.
DR   ProteinModelPortal; P80477; -.
DR   SMR; P80477; -.
DR   UniPathway; UPA00223; UER01006.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd00207; fer2; 1.
DR   Gene3D; 1.10.1060.10; -; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR006058; 2Fe2S_fd_BS.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   InterPro; IPR004489; Succ_DH/fum_Rdtase_Fe-S.
DR   InterPro; IPR025192; Succ_DH/fum_Rdtase_N.
DR   Pfam; PF13085; Fer2_3; 1.
DR   SUPFAM; SSF46548; SSF46548; 1.
DR   SUPFAM; SSF54292; SSF54292; 1.
DR   TIGRFAMs; TIGR00384; dhsB; 1.
DR   PROSITE; PS00197; 2FE2S_FER_1; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; 3Fe-4S; 4Fe-4S; Electron transport; Iron; Iron-sulfur;
KW   Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW   Oxidoreductase; Transport; Tricarboxylic acid cycle.
FT   CHAIN         1    239       Succinate dehydrogenase [ubiquinone]
FT                                iron-sulfur subunit.
FT                                /FTId=PRO_0000158696.
FT   DOMAIN       24     99       2Fe-2S ferredoxin-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00465}.
FT   DOMAIN      142    172       4Fe-4S ferredoxin-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        63     63       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL        68     68       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL        71     71       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL        83     83       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL       152    152       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       155    155       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       158    158       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       162    162       Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT   METAL       209    209       Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT   METAL       215    215       Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT   METAL       219    219       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   BINDING     167    167       Ubiquinone; shared with DHSD.
FT                                {ECO:0000250}.
SQ   SEQUENCE   239 AA;  27301 MW;  5209A3754CAC3E20 CRC64;
     MRPRNNNLNL KFIRIYRWTP SNQAEAKFSV HPIHTSNCGP MILDALIKIK DEQDSSLAFR
     RSCREGICGS CSMNIDGINT LACLKPIKTN ANIITIYPLP HMYIIKDLVP DLSNFFSQYK
     YIKPWLINNV PKKSEYLQSE KDRSELNGIY ECILCACCSA SCPSYWWNHD KYLGPAILLQ
     AYRWLADSRD TNAKERLKLL GGKSKLFKCH TIMNCSRTCP KSLNPGKAIA SIKHSINYS
//
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