GenomeNet

Database: UniProt
Entry: P80480
LinkDB: P80480
Original site: P80480 
ID   SDHB_RECAM              Reviewed;         239 AA.
AC   P80480;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   05-DEC-2018, entry version 101.
DE   RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit;
DE            EC=1.3.5.1;
DE   AltName: Full=Iron-sulfur subunit of complex II;
DE            Short=Ip;
GN   Name=SDH2; Synonyms=SDHB;
OS   Reclinomonas americana.
OG   Mitochondrion.
OC   Eukaryota; Jakobida; Histionidae; Reclinomonas.
OX   NCBI_TaxID=48483;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 50394;
RX   PubMed=8637872; DOI=10.1073/pnas.93.6.2328;
RA   Burger G., Lang B.F., Reith M., Gray M.W.;
RT   "Genes encoding the same three subunits of respiratory complex II are
RT   present in the mitochondrial DNA of two phylogenetically distant
RT   eukaryotes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996).
CC   -!- FUNCTION: Iron-sulfur protein (IP) subunit of succinate
CC       dehydrogenase (SDH) that is involved in complex II of the
CC       mitochondrial electron transport chain and is responsible for
CC       transferring electrons from succinate to ubiquinone (coenzyme Q).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + succinate = a quinol + fumarate;
CC         Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1;
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [3Fe-4S] cluster. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       fumarate from succinate (eukaryal route): step 1/1.
CC   -!- SUBUNIT: Component of complex II composed of four subunits: a
CC       flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b
CC       composed of a large and a small subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the succinate dehydrogenase/fumarate
CC       reductase iron-sulfur protein family. {ECO:0000305}.
DR   EMBL; AF007261; AAD11913.1; -; Genomic_DNA.
DR   PIR; S78180; S78180.
DR   RefSeq; NP_044798.1; NC_001823.1.
DR   ProteinModelPortal; P80480; -.
DR   SMR; P80480; -.
DR   GeneID; 801067; -.
DR   UniPathway; UPA00223; UER01006.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd00207; fer2; 1.
DR   Gene3D; 1.10.1060.10; -; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR006058; 2Fe2S_fd_BS.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   InterPro; IPR004489; Succ_DH/fum_Rdtase_Fe-S.
DR   InterPro; IPR025192; Succ_DH/fum_Rdtase_N.
DR   Pfam; PF13085; Fer2_3; 1.
DR   SUPFAM; SSF46548; SSF46548; 1.
DR   SUPFAM; SSF54292; SSF54292; 1.
DR   TIGRFAMs; TIGR00384; dhsB; 1.
DR   PROSITE; PS00197; 2FE2S_FER_1; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; 3Fe-4S; 4Fe-4S; Electron transport; Iron; Iron-sulfur;
KW   Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW   Oxidoreductase; Transport; Tricarboxylic acid cycle.
FT   CHAIN         1    239       Succinate dehydrogenase [ubiquinone]
FT                                iron-sulfur subunit.
FT                                /FTId=PRO_0000158697.
FT   DOMAIN       11    100       2Fe-2S ferredoxin-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00465}.
FT   DOMAIN      141    171       4Fe-4S ferredoxin-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        61     61       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL        66     66       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL        69     69       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL        81     81       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL       151    151       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       154    154       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       157    157       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       161    161       Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT   METAL       208    208       Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT   METAL       214    214       Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT   METAL       218    218       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   BINDING     166    166       Ubiquinone; shared with DHSD.
FT                                {ECO:0000250}.
SQ   SEQUENCE   239 AA;  27828 MW;  781C6FF0ED55375B CRC64;
     MNTKKEKIML FKVYRWNPDK KEKPHISTYS VDLNSCGPMV LDALIKIKNE QDSTLTFRRS
     CREGVCGSCA MNIDGTNTLA CIKSIDTNKK EMKIYPLPHM HIIKDLVPDL SNFYAQYKSI
     EPWMKTTEKK LDKEFYQSRN DREKLDGLYE CVLCACCSTS CPSYWWNSDK YLGPAVLLQA
     YRWIVDSRDQ GTRERLQYLE DPFKLYRCHT ILNCTKTCPK HLNPAQAIAK IKQNITLLT
//
DBGET integrated database retrieval system