ID VSPT2_BOTJA Reviewed; 19 AA.
AC P81883;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Thrombin-like enzyme TL-BJ 2;
DE Short=SVTLE;
DE EC=3.4.21.-;
DE AltName: Full=Fibrinogen-clotting enzyme TL-BJ isoform 2;
DE AltName: Full=Snake venom serine protease;
DE Short=SVSP;
DE Flags: Fragment;
OS Bothrops jararaca (Jararaca) (Bothrops jajaraca).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX NCBI_TaxID=8724;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND ACTIVITY REGULATION.
RC TISSUE=Venom;
RX PubMed=10744151;
RA Serrano S.M.T., Sampaio C.A.M., Mentele R., Camargo A.C.M., Fink E.;
RT "A novel fibrinogen-clotting enzyme, TL-BJ, from the venom of the snake
RT Bothrops jararaca: purification and characterization.";
RL Thromb. Haemost. 83:438-444(2000).
CC -!- FUNCTION: Thrombin-like snake venom serine protease. Causes the
CC specific clotting of fibrinogen (FGA) with release of fibrinopeptide A.
CC The aberrant fibrinogen is then incapable of being cross-linked,
CC forming easily dispersible clots. {ECO:0000269|PubMed:10744151}.
CC -!- ACTIVITY REGULATION: Inhibited by PMSF, but not by hirudin.
CC {ECO:0000269|PubMed:10744151}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- PTM: N-glycosylated.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00274}.
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DR AlphaFoldDB; P81883; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Blood coagulation cascade activating toxin; Direct protein sequencing;
KW Glycoprotein; Hemostasis impairing toxin; Hydrolase; Protease; Secreted;
KW Serine protease; Toxin.
FT CHAIN 1..>19
FT /note="Thrombin-like enzyme TL-BJ 2"
FT /id="PRO_0000088734"
FT DOMAIN 1..>19
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT NON_TER 19
SQ SEQUENCE 19 AA; 2072 MW; 5B6E7E2343EFE102 CRC64;
VVGGDECNIN EHRSLVAIF
//