GenomeNet

Database: UniProt
Entry: P83501
LinkDB: P83501
Original site: P83501 
ID   MSTAB_DROME             Reviewed;         448 AA.
AC   P83501;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 2.
DT   16-JAN-2019, entry version 111.
DE   RecName: Full=SET domain-containing protein SmydA-8, isoform B {ECO:0000305};
DE            EC=2.1.1.- {ECO:0000255|PROSITE-ProRule:PRU00190};
GN   Name=SmydA-8 {ECO:0000312|FlyBase:FBgn0053548};
GN   Synonyms=msta {ECO:0000312|FlyBase:FBgn0053548};
GN   ORFNames=CG33548 {ECO:0000312|FlyBase:FBgn0053548};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=B;
CC         IsoId=P83501-1; Sequence=Displayed;
CC         Note=No experimental confirmation available.;
CC       Name=A;
CC         IsoId=O46040-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; AE014298; AAF45751.3; -; Genomic_DNA.
DR   RefSeq; NP_001014718.1; NM_001014718.2. [P83501-1]
DR   ProteinModelPortal; P83501; -.
DR   BioGrid; 57739; 2.
DR   DIP; DIP-22689N; -.
DR   PRIDE; P83501; -.
DR   EnsemblMetazoa; FBtr0070421; FBpp0070405; FBgn0053548. [P83501-1]
DR   GeneID; 31200; -.
DR   UCSC; CG33548-RA; d. melanogaster. [P83501-1]
DR   CTD; 31200; -.
DR   FlyBase; FBgn0053548; SmydA-8.
DR   GeneTree; ENSGT00940000167795; -.
DR   GenomeRNAi; 31200; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0053548; Expressed in 14 organ(s), highest expression level in head.
DR   ExpressionAtlas; P83501; baseline and differential.
DR   Genevisible; P83501; DM.
DR   GO; GO:0000790; C:nuclear chromatin; ISS:FlyBase.
DR   GO; GO:0042826; F:histone deacetylase binding; ISS:FlyBase.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; ISS:FlyBase.
DR   GO; GO:0034968; P:histone lysine methylation; ISS:FlyBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:FlyBase.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Complete proteome; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    448       SET domain-containing protein SmydA-8,
FT                                isoform B.
FT                                /FTId=PRO_0000096608.
FT   DOMAIN       42    273       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   448 AA;  51113 MW;  F33AABD69D71E358 CRC64;
     MSTSTPVTEE PRSSSQMTIS ASTQELAELI NIHLGDLRPE EPSWRVADSP ISGRGIFATR
     EIAAGEELFR EHTLLVGPTA HRSMNLRTCT LCYRLIPGST DSAALCPAGC GLPVCSECRD
     STRHDLECKL FRKWKPLESQ RIEPRALRIL SVVRCFFLDE ASRKLLYAMQ ANMDRYYMQE
     VQRAADCFEH FPREQDMLDY FYRTICAFNT NAFESRSNVD GHEVLVRALF PLAGLLNHQC
     TPNAAHHFEN GETIVVCATE RIPAGAEITM SYAKLLWSTL ARKIFLGMTK HFICKCVRCQ
     DPTENGTYLS ALFCREQGCR GLVIPVQTRT LQPDWRCITC ENVFPHAKMA KYQDFALNTI
     NNRINSCSVQ DMIHFINELC PRFCPSSNYV LIEAKLNVIW RMTRFDHEEY TPEEMGHMDR
     YREEVLAILH KLGAGECTLK KLITGEIQ
//
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