GenomeNet

Database: UniProt
Entry: P86254
LinkDB: P86254
Original site: P86254 
ID   SODM_ALTAL              Reviewed;          25 AA.
AC   P86254;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   05-DEC-2018, entry version 25.
DE   RecName: Full=Superoxide dismutase [Mn], mitochondrial {ECO:0000250|UniProtKB:P04179};
DE            EC=1.15.1.1;
DE   AltName: Full=Manganese-dependent superoxide dismutase;
DE            Short=MnSOD;
DE   AltName: Allergen=Alt a MnSOD;
DE   Flags: Fragment;
OS   Alternaria alternata (Alternaria rot fungus) (Torula alternata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
OC   Pleosporaceae; Alternaria; Alternaria alternata group.
OX   NCBI_TaxID=5599;
RN   [1]
RP   PROTEIN SEQUENCE, ALLERGEN, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=CBS 104.26;
RX   PubMed=21255138; DOI=10.1111/j.1365-2222.2010.03671.x;
RA   Postigo I., Gutierrez-Rodriguez A., Fernandez J., Guisantes J.A.,
RA   Sunen E., Martinez J.;
RT   "Diagnostic value of Alt a 1, fungal enolase and manganese-dependent
RT   superoxide dismutase in the component-resolved diagnosis of allergy to
RT   pleosporaceae.";
RL   Clin. Exp. Allergy 41:443-451(2011).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological
CC       systems.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC         Evidence={ECO:0000250|UniProtKB:P04179};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000250|UniProtKB:P04179};
CC       Note=Binds 1 Mn(2+) ion per subunit.
CC       {ECO:0000250|UniProtKB:P04179};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P04179}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:P04179}.
CC   -!- ALLERGEN: Causes an allergic reaction in humans. Binds to IgE.
CC       {ECO:0000269|PubMed:21255138}.
CC   -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is:
CC       7, its MW is: 24 kDa.
CC   -!- MISCELLANEOUS: Could be used for the diagnosis of allergy to
CC       Pleosporaceae.
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000255}.
DR   SMR; P86254; -.
DR   Allergome; 11425; Alt a 14.0101.
DR   Allergome; 8737; Alt a 14.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.287.990; -; 1.
DR   InterPro; IPR019831; Mn/Fe_SOD_N.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   Pfam; PF00081; Sod_Fe_N; 1.
DR   SUPFAM; SSF46609; SSF46609; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Manganese; Metal-binding;
KW   Mitochondrion; Oxidoreductase.
FT   CHAIN        <1    >25       Superoxide dismutase [Mn], mitochondrial.
FT                                /FTId=PRO_0000392637.
FT   METAL         9      9       Manganese.
FT                                {ECO:0000250|UniProtKB:P04179}.
FT   NON_TER       1      1
FT   NON_TER      25     25
SQ   SEQUENCE   25 AA;  2711 MW;  4A47F8A2C717C6D6 CRC64;
     FNAGGHINHS LFWQNLAPAS SNEAK
//
DBGET integrated database retrieval system