ID   DLX2_ELECQ              Reviewed;         103 AA.
AC   P87393;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   22-FEB-2023, entry version 89.
DE   RecName: Full=Homeobox protein DLX-2;
DE   Flags: Fragment;
GN   Name=DLX2;
OS   Eleutherodactylus coqui (Puerto Rican coqui).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Eleutherodactylidae;
OC   Eleutherodactylinae; Eleutherodactylus; Eleutherodactylus.
OX   NCBI_TaxID=57060;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=8873761; DOI=10.1006/dbio.1996.0248;
RA   Fang H., Elinson R.P.;
RT   "Patterns of distal-less gene expression and inductive interactions in the
RT   head of the direct developing frog Eleutherodactylus coqui.";
RL   Dev. Biol. 179:160-172(1996).
CC   -!- FUNCTION: May act as a transcriptional activator by promoting terminal
CC       differentiation of interneurons in the developing retina. Likely to
CC       play a regulatory role in the development of the ventral forebrain. May
CC       play a role in craniofacial patterning and morphogenesis.
CC       {ECO:0000250|UniProtKB:P40764}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: First appears in neural crest cells of the
CC       mandibular stream at stage 15. By TS4 (Townsend and Stewart) is active
CC       in the migrating neural crest cells of all streams: the mandibular,
CC       hyoid, and first and second branchial. Continuously expressed in the
CC       branchial arches through TS5 and TS6 and begins to be expressed at the
CC       edges of the limb buds at TS6. Detected in cells of the forebrain at
CC       stage TS5. {ECO:0000269|PubMed:8873761}.
CC   -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
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DR   EMBL; S83211; AAD14431.1; -; mRNA.
DR   AlphaFoldDB; P87393; -.
DR   SMR; P87393; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   PANTHER; PTHR24327; HOMEOBOX PROTEIN; 1.
DR   PANTHER; PTHR24327:SF23; HOMEOBOX PROTEIN DLX-2; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN           <1..>103
FT                   /note="Homeobox protein DLX-2"
FT                   /id="PRO_0000049041"
FT   DNA_BIND        54..>103
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          15..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         103
SQ   SEQUENCE   103 AA;  11658 MW;  613BB29ED613522A CRC64;
     GIPDSAKSYD LTSYNGSYSS YGPYGTSPSP THNDQEKEEC EPEIRIVNGK PKKVRKPRTI
     YSSFQLAALQ RRFQKTQYLA LPERAELAAS LGLTQTQVKI WFQ
//