GenomeNet

Database: UniProt
Entry: P89910_SIVTA
LinkDB: P89910_SIVTA
Original site: P89910_SIVTA 
ID   P89910_SIVTA            Unreviewed;       222 AA.
AC   P89910;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1997, sequence version 1.
DT   12-AUG-2020, entry version 92.
DE   RecName: Full=Protein Nef {ECO:0000256|RuleBase:RU000344};
GN   Name=nef {ECO:0000313|EMBL:AAC57058.1};
OS   Simian immunodeficiency virus - agm.tan-1.
OC   Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=349975 {ECO:0000313|EMBL:AAC57058.1, ECO:0000313|Proteomes:UP000259687};
RN   [1] {ECO:0000313|EMBL:AAC57058.1, ECO:0000313|Proteomes:UP000259687}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=tantalus-1 {ECO:0000313|Proteomes:UP000259687};
RX   PubMed=9123848; DOI=10.1006/viro.1996.8387;
RA   Soares M.A., Robertson D.L., Hui H., Allan J.S., Shaw G.M., Hahn B.H.;
RT   "A full-length and replication-competent proviral clone of SIVAGM from
RT   tantalus monkeys.";
RL   Virology 228:394-399(1997).
CC   -!- SIMILARITY: Belongs to the lentivirus primate group Nef protein family.
CC       {ECO:0000256|ARBA:ARBA00006933, ECO:0000256|RuleBase:RU000344}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U58991; AAC57058.1; -; Genomic_DNA.
DR   Proteomes; UP000259687; Genome.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0030683; P:mitigation of host immune response by virus; IEA:UniProtKB-KW.
DR   GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.62.10; -; 1.
DR   InterPro; IPR027481; HIV-1_Nef_core_sf.
DR   InterPro; IPR001558; HIV_Nef.
DR   Pfam; PF00469; F-protein; 1.
DR   SUPFAM; SSF55671; SSF55671; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Lipoprotein {ECO:0000256|RuleBase:RU000344};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707, ECO:0000256|RuleBase:RU000344};
KW   Reference proteome {ECO:0000313|Proteomes:UP000259687};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280,
KW   ECO:0000256|RuleBase:RU000344};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026, ECO:0000256|RuleBase:RU000344}.
FT   REGION          42..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..58
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   222 AA;  25703 MW;  C0B94F35096173AD CRC64;
     MGGSNSKREQ QGLLRLWRAL RKAPVVRYGM LADPLIGQSS NIQEECDKNW NGGSTRRGKS
     TPEGRKLAAD DTWDDWEPEE EEVGFPVRPR VPLRQMTYKL AVDFSHFLKE KGGLEGIYWS
     PKREQILNLY ALNEWGIIDD WQAYSPGPGT RKPRCFGFCF ELVPVDVSQE AQDERHCLLH
     PAQIEWESDP WKETLVWKFN PLLAVQYNPD SFKDMHGLVK RK
//
DBGET integrated database retrieval system