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Database: UniProt
Entry: P95029_MYCTU
LinkDB: P95029_MYCTU
Original site: P95029_MYCTU 
ID   P95029_MYCTU            Unreviewed;      3069 AA.
AC   P95029; F2GH34; I6Y0Z1;
DT   01-MAY-1997, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 3.
DT   18-JUL-2018, entry version 132.
DE   SubName: Full=Probable fatty acid synthase Fas (Fatty acid synthetase) {ECO:0000313|EMBL:CCP45318.1};
GN   Name=fas {ECO:0000313|EMBL:CCP45318.1};
GN   OrderedLocusNames=Rv2524c {ECO:0000313|EMBL:CCP45318.1};
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332 {ECO:0000313|EMBL:CCP45318.1, ECO:0000313|Proteomes:UP000001584};
RN   [1] {ECO:0000313|EMBL:CCP45318.1, ECO:0000313|Proteomes:UP000001584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv {ECO:0000313|Proteomes:UP000001584};
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F.,
RA   Badcock K., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S.,
RA   Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.,
RA   Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J.,
RA   Rutter S., Seeger K., Skelton J., Squares R., Squares S.,
RA   Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the
RT   complete genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2] {ECO:0000213|PubMed:21969609}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21969609; DOI=10.1074/mcp.M111.011445;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B.,
RA   Yadav A.K., Shrivastava P., Marimuthu A., Anand S., Sundaram H.,
RA   Kingsbury R., Harsha H.C., Nair B., Prasad T.S., Chauhan D.S.,
RA   Katoch K., Katoch V.M., Kumar P., Chaerkady R., Ramachandran S.,
RA   Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high
RT   resolution mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INTERACTION:
CC       Self; NbExp=2; IntAct=EBI-16060651, EBI-16060651;
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DR   EMBL; AL123456; CCP45318.1; -; Genomic_DNA.
DR   RefSeq; NP_217040.1; NC_000962.3.
DR   RefSeq; WP_003900843.1; NZ_KK339370.1.
DR   DIP; DIP-60403N; -.
DR   STRING; 83332.Rv2524c; -.
DR   ChEMBL; CHEMBL2011; -.
DR   PaxDb; P95029; -.
DR   EnsemblBacteria; AIR15294; AIR15294; LH57_13830.
DR   EnsemblBacteria; CCP45318; CCP45318; Rv2524c.
DR   GeneID; 887704; -.
DR   KEGG; mtu:Rv2524c; -.
DR   KEGG; mtv:RVBD_2524c; -.
DR   PATRIC; fig|83332.111.peg.2822; -.
DR   eggNOG; ENOG4107RX2; Bacteria.
DR   eggNOG; COG0304; LUCA.
DR   eggNOG; COG0331; LUCA.
DR   eggNOG; COG2030; LUCA.
DR   eggNOG; COG4981; LUCA.
DR   eggNOG; COG4982; LUCA.
DR   HOGENOM; HOG000051526; -.
DR   KO; K11533; -.
DR   OMA; VEPIWAD; -.
DR   BioCyc; MetaCyc:G185E-6762-MONOMER; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005618; C:cell wall; IDA:MTBBASE.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IDA:MTBBASE.
DR   GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
DR   GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IBA:GO_Central.
DR   GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR   GO; GO:0040007; P:growth; IMP:MTBBASE.
DR   Gene3D; 3.20.20.70; -; 1.
DR   Gene3D; 3.40.366.10; -; 3.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013565; DUF1729.
DR   InterPro; IPR003965; Fatty_acid_synthase.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR002539; MaoC_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08354; DUF1729; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF01575; MaoC_dehydratas; 1.
DR   PRINTS; PR01483; FASYNTHASE.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52151; SSF52151; 5.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   SUPFAM; SSF54637; SSF54637; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001584};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001584}.
FT   COILED     2378   2398       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3069 AA;  326255 MW;  25EF022D54943D4C CRC64;
     MTIHEHDRVS ADRGGDSPHT THALVDRLMA GEPYAVAFGG QGSAWLETLE ELVSATGIET
     ELATLVGEAE LLLDPVTDEL IVVRPIGFEP LQWVRALAAE DPVPSDKHLT SAAVSVPGVL
     LTQIAATRAL ARQGMDLVAT PPVAMAGHSQ GVLAVEALKA GGARDVELFA LAQLIGAAGT
     LVARRRGISV LGDRPPMVSV TNADPERIGR LLDEFAQDVR TVLPPVLSIR NGRRAVVITG
     TPEQLSRFEL YCRQISEKEE ADRKNKVRGG DVFSPVFEPV QVEVGFHTPR LSDGIDIVAG
     WAEKAGLDVA LARELADAIL IRKVDWVDEI TRVHAAGARW ILDLGPGDIL TRLTAPVIRG
     LGIGIVPAAT RGGQRNLFTV GATPEVARAW SSYAPTVVRL PDGRVKLSTK FTRLTGRSPI
     LLAGMTPTTV DAKIVAAAAN AGHWAELAGG GQVTEEIFGN RIEQMAGLLE PGRTYQFNAL
     FLDPYLWKLQ VGGKRLVQKA RQSGAAIDGV VISAGIPDLD EAVELIDELG DIGISHVVFK
     PGTIEQIRSV IRIATEVPTK PVIMHVEGGR AGGHHSWEDL DDLLLATYSE LRSRANITVC
     VGGGIGTPRR AAEYLSGRWA QAYGFPLMPI DGILVGTAAM ATKESTTSPS VKRMLVDTQG
     TDQWISAGKA QGGMASSRSQ LGADIHEIDN SASRCGRLLD EVAGDAEAVA ERRDEIIAAM
     AKTAKPYFGD VADMTYLQWL RRYVELAIGE GNSTADTASV GSPWLADTWR DRFEQMLQRA
     EARLHPQDFG PIQTLFTDAG LLDNPQQAIA ALLARYPDAE TVQLHPADVP FFVTLCKTLG
     KPVNFVPVID QDVRRWWRSD SLWQAHDARY DADAVCIIPG TASVAGITRM DEPVGELLDR
     FEQAAIDEVL GAGVEPKDVA SRRLGRADVA GPLAVVLDAP DVRWAGRTVT NPVHRIADPA
     EWQVHDGPEN PRATHSSTGA RLQTHGDDVA LSVPVSGTWV DIRFTLPANT VDGGTPVIAT
     EDATSAMRTV LAIAAGVDSP EFLPAVANGT ATLTVDWHPE RVADHTGVTA TFGEPLAPSL
     TNVPDALVGP CWPAVFAAIG SAVTDTGEPV VEGLLSLVHL DHAARVVGQL PTVPAQLTVT
     ATAANATDTD MGRVVPVSVV VTGADGAVIA TLEERFAILG RTGSAELADP ARAGGAVSAN
     ATDTPRRRRR DVTITAPVDM RPFAVVSGDH NPIHTDRAAA LLAGLESPIV HGMWLSAAAQ
     HAVTATDGQA RPPARLVGWT ARFLGMVRPG DEVDFRVERV GIDQGAEIVD VAARVGSDLV
     MSASARLAAP KTVYAFPGQG IQHKGMGMEV RARSKAARKV WDTADKFTRD TLGFSVLHVV
     RDNPTSIIAS GVHYHHPDGV LYLTQFTQVA MATVAAAQVA EMREQGAFVE GAIACGHSVG
     EYTALACVTG IYQLEALLEM VFHRGSKMHD IVPRDELGRS NYRLAAIRPS QIDLDDADVP
     AFVAGIAEST GEFLEIVNFN LRGSQYAIAG TVRGLEALEA EVERRRELTG GRRSFILVPG
     IDVPFHSRVL RVGVAEFRRS LDRVMPRDAD PDLIIGRYIP NLVPRLFTLD RDFIQEIRDL
     VPAEPLDEIL ADYDTWLRER PREMARTVFI ELLAWQFASP VRWIETQDLL FIEEAAGGLG
     VERFVEIGVK SSPTVAGLAT NTLKLPEYAH STVEVLNAER DAAVLFATDT DPEPEPEEDE
     PVAESPAPDV VSEAAPVAPA ASSAGPRPDD LVFDAADATL ALIALSAKMR IDQIEELDSI
     ESITDGASSR RNQLLVDLGS ELNLGAIDGA AESDLAGLRS QVTKLARTYK PYGPVLSDAI
     NDQLRTVLGP SGKRPGAIAE RVKKTWELGE GWAKHVTVEV ALGTREGSSV RGGAMGHLHE
     GALADAASVD KVIDAAVASV AARQGVSVAL PSAGSGGGAT IDAAALSEFT DQITGREGVL
     ASAARLVLGQ LGLDDPVNAL PAAPDSELID LVTAELGADW PRLVAPVFDP KKAVVFDDRW
     ASAREDLVKL WLTDEGDIDA DWPRLAERFE GAGHVVATQA TWWQGKSLAA GRQIHASLYG
     RIAAGAENPE PGRYGGEVAV VTGASKGSIA ASVVARLLDG GATVIATTSK LDEERLAFYR
     TLYRDHARYG AALWLVAANM ASYSDVDALV EWIGTEQTES LGPQSIHIKD AQTPTLLFPF
     AAPRVVGDLS EAGSRAEMEM KVLLWAVQRL IGGLSTIGAE RDIASRLHVV LPGSPNRGMF
     GGDGAYGEAK SALDAVVSRW HAESSWAARV SLAHALIGWT RGTGLMGHND AIVAAVEEAG
     VTTYSTDEMA ALLLDLCDAE SKVAAARSPI KADLTGGLAE ANLDMAELAA KAREQMSAAA
     AVDEDAEAPG AIAALPSPPR GFTPAPPPQW DDLDVDPADL VVIVGGAEIG PYGSSRTRFE
     MEVENELSAA GVLELAWTTG LIRWEDDPQP GWYDTESGEM VDESELVQRY HDAVVQRVGI
     REFVDDGAID PDHASPLLVS VFLEKDFAFV VSSEADARAF VEFDPEHTVI RPVPDSTDWQ
     VIRKAGTEIR VPRKTKLSRV VGGQIPTGFD PTVWGISADM AGSIDRLAVW NMVATVDAFL
     SSGFSPAEVM RYVHPSLVAN TQGTGMGGGT SMQTMYHGNL LGRNKPNDIF QEVLPNIIAA
     HVVQSYVGSY GAMIHPVAAC ATAAVSVEEG VDKIRLGKAQ LVVAGGLDDL TLEGIIGFGD
     MAATADTSMM CGRGIHDSKF SRPNDRRRLG FVEAQGGGTI LLARGDLALR MGLPVLAVVA
     FAQSFGDGVH TSIPAPGLGA LGAGRGGKDS PLARALAKLG VAADDVAVIS KHDTSTLAND
     PNETELHERL ADALGRSEGA PLFVVSQKSL TGHAKGGAAV FQMMGLCQIL RDGVIPPNRS
     LDCVDDELAG SAHFVWVRDT LRLGGKFPLK AGMLTSLGFG HVSGLVALVH PQAFIASLDP
     AQRADYQRRA DARLLAGQRR LASAIAGGAP MYQRPGDRRF DHHAPERPQE ASMLLNPAAR
     LGDGEAYIG
//
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