ID MEIS3_MOUSE Reviewed; 378 AA.
AC P97368; Q149R5; Q99L81;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 27-MAR-2024, entry version 160.
DE RecName: Full=Homeobox protein Meis3;
DE AltName: Full=Meis1-related protein 2;
GN Name=Meis3; Synonyms=Mrg2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=Swiss Webster;
RX PubMed=8950991;
RA Nakamura T., Jenkins N.A., Copeland N.G.;
RT "Identification of a new family of Pbx-related homeobox genes.";
RL Oncogene 13:2235-2242(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=21059917; DOI=10.1073/pnas.1007001107;
RA Liu J., Wang Y., Birnbaum M.J., Stoffers D.A.;
RT "Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell
RT survival via PDK1.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:20494-20499(2010).
CC -!- FUNCTION: Transcriptional regulator which directly modulates PDPK1
CC expression, thus promoting survival of pancreatic beta-cells. Also
CC regulates expression of NDFIP1, BNIP3, and CCNG1.
CC {ECO:0000269|PubMed:21059917}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21059917}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P97368-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P97368-2; Sequence=VSP_012894;
CC -!- TISSUE SPECIFICITY: Expressed at high levels in the brain. Significant
CC expression also observed in the heart, spleen and lung. Expressed in
CC pancreatic islets (beta-cells and non-beta-cells) (PubMed:21059917).
CC {ECO:0000269|PubMed:21059917}.
CC -!- DEVELOPMENTAL STAGE: Not expressed until 11 days in embryonic
CC development.
CC -!- SIMILARITY: Belongs to the TALE/MEIS homeobox family. {ECO:0000305}.
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DR EMBL; U57344; AAC52949.1; -; mRNA.
DR EMBL; CH466654; EDL42107.1; -; Genomic_DNA.
DR EMBL; BC003762; AAH03762.1; -; mRNA.
DR EMBL; BC117532; AAI17533.1; -; mRNA.
DR CCDS; CCDS39782.1; -. [P97368-1]
DR CCDS; CCDS71892.1; -. [P97368-2]
DR RefSeq; NP_001264917.1; NM_001277988.2. [P97368-2]
DR RefSeq; NP_001264918.1; NM_001277989.2. [P97368-2]
DR RefSeq; NP_001289401.1; NM_001302472.1. [P97368-1]
DR RefSeq; NP_032653.2; NM_008627.4. [P97368-1]
DR RefSeq; XP_006539666.1; XM_006539603.3. [P97368-1]
DR AlphaFoldDB; P97368; -.
DR SMR; P97368; -.
DR BioGRID; 201488; 2.
DR IntAct; P97368; 3.
DR STRING; 10090.ENSMUSP00000002495; -.
DR PhosphoSitePlus; P97368; -.
DR MaxQB; P97368; -.
DR PaxDb; 10090-ENSMUSP00000002495; -.
DR Antibodypedia; 31559; 478 antibodies from 25 providers.
DR DNASU; 17537; -.
DR Ensembl; ENSMUST00000002495.18; ENSMUSP00000002495.11; ENSMUSG00000041420.19. [P97368-1]
DR Ensembl; ENSMUST00000176506.8; ENSMUSP00000134918.2; ENSMUSG00000041420.19. [P97368-2]
DR GeneID; 17537; -.
DR KEGG; mmu:17537; -.
DR UCSC; uc009fha.3; mouse. [P97368-1]
DR UCSC; uc009fhd.3; mouse. [P97368-2]
DR AGR; MGI:108519; -.
DR CTD; 56917; -.
DR MGI; MGI:108519; Meis3.
DR VEuPathDB; HostDB:ENSMUSG00000041420; -.
DR eggNOG; KOG0773; Eukaryota.
DR GeneTree; ENSGT00940000161057; -.
DR HOGENOM; CLU_023139_1_1_1; -.
DR InParanoid; P97368; -.
DR OMA; EDFPASC; -.
DR OrthoDB; 3180467at2759; -.
DR PhylomeDB; P97368; -.
DR TreeFam; TF318093; -.
DR BioGRID-ORCS; 17537; 1 hit in 79 CRISPR screens.
DR ChiTaRS; Meis3; mouse.
DR PRO; PR:P97368; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P97368; Protein.
DR Bgee; ENSMUSG00000041420; Expressed in cortical plate and 183 other cell types or tissues.
DR ExpressionAtlas; P97368; baseline and differential.
DR Genevisible; P97368; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0009880; P:embryonic pattern specification; IBA:GO_Central.
DR GO; GO:0001654; P:eye development; IBA:GO_Central.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IMP:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR032453; PKNOX/Meis_N.
DR PANTHER; PTHR11850:SF190; HOMEOBOX PROTEIN MEIS3-RELATED; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF16493; Meis_PKNOX_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..378
FT /note="Homeobox protein Meis3"
FT /id="PRO_0000049111"
FT DOMAIN 99..182
FT /note="MEIS N-terminal"
FT /evidence="ECO:0000255"
FT DNA_BIND 265..327
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 24..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 152..168
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_012894"
FT CONFLICT 18
FT /note="T -> M (in Ref. 3; AAH03762)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="A -> T (in Ref. 1; AAC52949)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 378 AA; 41726 MW; 3D0CB5FD586741B4 CRC64;
MARRYDELRH YPGITEHTTA LASFSEAAPS VPRAPGPYTP HRPPQLQAPG LDSDSLKREK
DDIYGHPLFP LLALVFEKCE LATCSPRDGA SAGLGSPPGG DVCSSDSFNE DIAAFAKQIR
SERPLFSSNP ELDNLMVQAI QVLRFHLLEL EKVHDLCDNF CHRYITCLKG KMPIDLVIED
RDGSCREDLE DYAASCPSLP DQNTTWIRDH EDSGSVHLGT PGPSSGGLAS QSGDNSSDQG
DGLDTSVASP SSAGEDEDLD LERRRNKKRG IFPKVATNIM RAWLFQHLSH PYPSEEQKKQ
LAQDTGLTIL QVNNWFINAR RRIVQPMIDQ SNRTGQGASF NPEGQPMAGF TETQPQVTVR
TPGSMGMNLN LEGEWHYL
//
