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Database: UniProt
Entry: P97607
LinkDB: P97607
Original site: P97607 
ID   JAG2_RAT                Reviewed;        1202 AA.
AC   P97607;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   13-FEB-2019, entry version 140.
DE   RecName: Full=Protein jagged-2;
DE            Short=Jagged2;
DE   Flags: Fragment;
GN   Name=Jag2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8948600; DOI=10.1006/dbio.1996.0310;
RA   Shawber C., Boulter J., Lindsell C.E., Weinmaster G.;
RT   "Jagged2: a serrate-like gene expressed during rat embryogenesis.";
RL   Dev. Biol. 180:370-376(1996).
CC   -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC       signaling. May have a role in neurogenesis in the peripheral
CC       nervous system, limb development and in the adult brain.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- DEVELOPMENTAL STAGE: At stage E12.5 it is detected in dorsal root
CC       ganglia, AER, and surface ectoderm. At E14.5, found as well in
CC       cranial ganglia, thymus and olfactory epithelia. At E16.5, found
CC       as well in salivary gland, tooth buds and hair follicles.
DR   EMBL; U70050; AAC52946.1; -; mRNA.
DR   UniGene; Rn.22459; -.
DR   ProteinModelPortal; P97607; -.
DR   SMR; P97607; -.
DR   STRING; 10116.ENSRNOP00000019213; -.
DR   jPOST; P97607; -.
DR   PaxDb; P97607; -.
DR   PRIDE; P97607; -.
DR   UCSC; RGD:2938; rat.
DR   RGD; 2938; Jag2.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; ENOG410XP6K; LUCA.
DR   HOGENOM; HOG000113124; -.
DR   HOVERGEN; HBG031645; -.
DR   InParanoid; P97607; -.
DR   PhylomeDB; P97607; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR   GO; GO:0005112; F:Notch binding; TAS:RGD.
DR   GO; GO:0009912; P:auditory receptor cell fate commitment; ISS:UniProtKB.
DR   GO; GO:0007420; P:brain development; IEP:RGD.
DR   GO; GO:0030154; P:cell differentiation; NAS:UniProtKB.
DR   GO; GO:0001709; P:cell fate determination; NAS:UniProtKB.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; NAS:UniProtKB.
DR   GO; GO:0008584; P:male gonad development; IEP:RGD.
DR   GO; GO:0007219; P:Notch signaling pathway; NAS:UniProtKB.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; ISS:UniProtKB.
DR   GO; GO:0045595; P:regulation of cell differentiation; TAS:RGD.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR   GO; GO:0007283; P:spermatogenesis; IMP:RGD.
DR   GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
DR   GO; GO:0045061; P:thymic T cell selection; ISS:UniProtKB.
DR   GO; GO:0042060; P:wound healing; IEP:UniProtKB.
DR   InterPro; IPR001774; DSL.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR033108; Jag2.
DR   InterPro; IPR026219; Jagged/Serrate.
DR   InterPro; IPR011651; Notch_ligand_N.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR44097:SF1; PTHR44097:SF1; 1.
DR   Pfam; PF01414; DSL; 1.
DR   Pfam; PF00008; EGF; 9.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF12661; hEGF; 3.
DR   Pfam; PF07657; MNNL; 1.
DR   PRINTS; PR02059; JAGGEDFAMILY.
DR   SMART; SM00051; DSL; 1.
DR   SMART; SM00181; EGF; 16.
DR   SMART; SM00179; EGF_CA; 14.
DR   SMART; SM00215; VWC_out; 1.
DR   SUPFAM; SSF57184; SSF57184; 2.
DR   PROSITE; PS00010; ASX_HYDROXYL; 10.
DR   PROSITE; PS51051; DSL; 1.
DR   PROSITE; PS00022; EGF_1; 15.
DR   PROSITE; PS01186; EGF_2; 11.
DR   PROSITE; PS50026; EGF_3; 15.
DR   PROSITE; PS01187; EGF_CA; 7.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Developmental protein; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway;
KW   Phosphoprotein; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN        <1   1202       Protein jagged-2.
FT                                /FTId=PRO_0000055632.
FT   TOPO_DOM     <1   1037       Extracellular. {ECO:0000255}.
FT   TRANSMEM   1038   1058       Helical. {ECO:0000255}.
FT   TOPO_DOM   1059   1202       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      150    194       DSL. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00377}.
FT   DOMAIN      195    228       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      229    259       EGF-like 2; atypical.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      261    299       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      301    337       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      339    375       EGF-like 5; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      377    413       EGF-like 6; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      415    450       EGF-like 7; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      452    488       EGF-like 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      490    527       EGF-like 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      529    589       EGF-like 10; atypical.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      591    627       EGF-like 11; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      629    665       EGF-like 12; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      667    703       EGF-like 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      706    742       EGF-like 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      744    780       EGF-like 15; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      782    818       EGF-like 16; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   MOD_RES    1080   1080       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9Y219}.
FT   CARBOHYD    107    107       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    525    525       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    574    574       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    707    707       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1015   1015       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    152    161       {ECO:0000250}.
FT   DISULFID    165    177       {ECO:0000250}.
FT   DISULFID    185    194       {ECO:0000250}.
FT   DISULFID    199    210       {ECO:0000250}.
FT   DISULFID    203    216       {ECO:0000250}.
FT   DISULFID    218    227       {ECO:0000250}.
FT   DISULFID    230    241       {ECO:0000250}.
FT   DISULFID    236    247       {ECO:0000250}.
FT   DISULFID    249    258       {ECO:0000250}.
FT   DISULFID    265    277       {ECO:0000250}.
FT   DISULFID    271    287       {ECO:0000250}.
FT   DISULFID    289    298       {ECO:0000250}.
FT   DISULFID    305    316       {ECO:0000250}.
FT   DISULFID    310    325       {ECO:0000250}.
FT   DISULFID    327    336       {ECO:0000250}.
FT   DISULFID    343    354       {ECO:0000250}.
FT   DISULFID    348    363       {ECO:0000250}.
FT   DISULFID    365    374       {ECO:0000250}.
FT   DISULFID    381    392       {ECO:0000250}.
FT   DISULFID    386    401       {ECO:0000250}.
FT   DISULFID    403    412       {ECO:0000250}.
FT   DISULFID    419    429       {ECO:0000250}.
FT   DISULFID    423    438       {ECO:0000250}.
FT   DISULFID    440    449       {ECO:0000250}.
FT   DISULFID    456    467       {ECO:0000250}.
FT   DISULFID    461    476       {ECO:0000250}.
FT   DISULFID    478    487       {ECO:0000250}.
FT   DISULFID    495    506       {ECO:0000250}.
FT   DISULFID    500    515       {ECO:0000250}.
FT   DISULFID    517    526       {ECO:0000250}.
FT   DISULFID    544    567       {ECO:0000255}.
FT   DISULFID    561    577       {ECO:0000255}.
FT   DISULFID    579    588       {ECO:0000250}.
FT   DISULFID    595    606       {ECO:0000250}.
FT   DISULFID    600    615       {ECO:0000250}.
FT   DISULFID    617    626       {ECO:0000250}.
FT   DISULFID    633    644       {ECO:0000250}.
FT   DISULFID    638    653       {ECO:0000250}.
FT   DISULFID    655    664       {ECO:0000250}.
FT   DISULFID    671    682       {ECO:0000250}.
FT   DISULFID    676    691       {ECO:0000250}.
FT   DISULFID    693    702       {ECO:0000250}.
FT   DISULFID    710    721       {ECO:0000250}.
FT   DISULFID    715    730       {ECO:0000250}.
FT   DISULFID    732    741       {ECO:0000250}.
FT   DISULFID    748    759       {ECO:0000250}.
FT   DISULFID    753    768       {ECO:0000250}.
FT   DISULFID    770    779       {ECO:0000250}.
FT   DISULFID    786    797       {ECO:0000250}.
FT   DISULFID    791    806       {ECO:0000250}.
FT   DISULFID    808    817       {ECO:0000250}.
FT   NON_TER       1      1
SQ   SEQUENCE   1202 AA;  129705 MW;  08CB44E5271FF8BE CRC64;
     GACCDGDGRT TRAGGCGRDE CDTYVRVCLK EYQAKVTPTG PCSYGYGATP VLGSNSFYLP
     PAGAAGDRAR ARSRTGGHQD PGLVVIPFQF AWPRSFTLIV EAWDWDNDTT PDEELLIERV
     SHAGMINPED RWKSLHFSGH VAHLELQIRV RCDENYYSAT CNKFCRPRND FFGHYTCDQY
     GNKACMDGWM GKECKEAVCK QGCNLLHGGC TVPGECRCSY GWQGKFCDEC VPYPGCVHGS
     CVEPWHCDCE TNWGGLLCDK DLNYCGSHHP CVNGGTCINA EPDQYLCACP DGYLGKNCER
     AEHACASNPC ANGGSCHEVL SGFECHCPSG WSGPTCALDI DECASNPCAA GGTCVDQVDG
     FECICPEQWV GATCQLDANE CEGKPCLNAF SCKNLIGGYY CDCLPGWKGA NCHININDCH
     GQCQHGGTCK DLVNGYQCVC PRGFGGRHCE LEYYKCASSP CRRGGICEDL VDGFRCHCPR
     GLSGPLCEVD VDLWCEPNPC LNGARCYNLE DDYYCACPED FGGKNCSVPR ETCPGGACRV
     IDGCGFEAGS RAHGAAPSGV CGPHGHCVSL PGGNFSCICD SGFTGTYCHE NIDDCMGQPC
     RNGGTCIDEV DSFACFCPSG WEGELCDINP NDCLPDPCHS RGRCYDLVND FYCVCDDGWK
     DKTCHSREFQ CDAYTCSNGG TCYDSGDTFR CACPPGWKGS TCTIAKNSSC VPNPCVNGGT
     CVGSGDSFSC ICRDGWEGRT CTHNTNDCNP LPCYNGGICV DGVNWFRCEC APGFAGPDCR
     INIDECQSSP CAYGATCVDE INGYRCSCPP GRSGPRCQEV VIFTRPCWSR GVSFPHGSSW
     VEDCNSCRCL DGHRDCSKVW CGWKPCLLSP QPSALSAQCP PGQQCREKAM GQCLQPPCEN
     WGECTAEDPL PPSTPCLPRT THLDNNCARL TLHFNRDQVP QGTTVGAICS GIRALPATRA
     AARDRLLLLL CDRASSGASA VEVAVSFSPA RDLPDSSLIQ STAHAIVAAI TQRGNSSLLL
     AVTEVKVETV VMGGSSTGLL VPVLCSVFSV LWLACMVICV WWTRKRRKER ERSRLPRDES
     ANNQWAPLNP IRNPIERPGS SGLGTGGHKD VLYQCKNFTP PPRRAGEALP GPASHGAGGE
     DEEDEELSRG DGRLSRSREV PLTQIHQRPQ LLPGKASLLA PGPKVDNRAV RSTKDVRCAG
     RE
//
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