ID S100G_MOUSE Reviewed; 79 AA.
AC P97816;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 24-JAN-2024, entry version 156.
DE RecName: Full=Protein S100-G;
DE AltName: Full=Calbindin-D9k;
DE AltName: Full=S100 calcium-binding protein G;
DE AltName: Full=Vitamin D-dependent calcium-binding protein, intestinal;
DE Short=CABP;
GN Name=S100g; Synonyms=Calb3, S100d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1 / ICR;
RA Tatsumi K., Higuchi T., Fujiwara H., Nakayama T., Itoh K., Mori T.,
RA Fujita J.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 23-62.
RC STRAIN=ICR; TISSUE=Placenta;
RA Ogura Y., Takakura N., Yoshida H., Nishikawa S.;
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the S-100 family. {ECO:0000305}.
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DR EMBL; AF028071; AAB84041.1; -; mRNA.
DR EMBL; U88544; AAB48839.1; -; mRNA.
DR CCDS; CCDS41203.1; -.
DR RefSeq; NP_033919.1; NM_009789.2.
DR AlphaFoldDB; P97816; -.
DR SMR; P97816; -.
DR STRING; 10090.ENSMUSP00000045120; -.
DR iPTMnet; P97816; -.
DR PhosphoSitePlus; P97816; -.
DR jPOST; P97816; -.
DR PaxDb; 10090-ENSMUSP00000045120; -.
DR PeptideAtlas; P97816; -.
DR ProteomicsDB; 255431; -.
DR Antibodypedia; 4324; 83 antibodies from 15 providers.
DR DNASU; 12309; -.
DR Ensembl; ENSMUST00000038769.3; ENSMUSP00000045120.3; ENSMUSG00000040808.5.
DR GeneID; 12309; -.
DR KEGG; mmu:12309; -.
DR UCSC; uc009uus.1; mouse.
DR AGR; MGI:104528; -.
DR CTD; 795; -.
DR MGI; MGI:104528; S100g.
DR VEuPathDB; HostDB:ENSMUSG00000040808; -.
DR eggNOG; ENOG502T3Z3; Eukaryota.
DR GeneTree; ENSGT00530000064238; -.
DR HOGENOM; CLU_138624_4_0_1; -.
DR InParanoid; P97816; -.
DR OMA; QKYAAKE; -.
DR OrthoDB; 4248222at2759; -.
DR PhylomeDB; P97816; -.
DR BioGRID-ORCS; 12309; 1 hit in 77 CRISPR screens.
DR ChiTaRS; S100g; mouse.
DR PRO; PR:P97816; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; P97816; Protein.
DR Bgee; ENSMUSG00000040808; Expressed in duodenum and 60 other cell types or tissues.
DR ExpressionAtlas; P97816; baseline and differential.
DR Genevisible; P97816; MM.
DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0048306; F:calcium-dependent protein binding; IBA:GO_Central.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0005499; F:vitamin D binding; IEA:UniProtKB-KW.
DR CDD; cd00213; S-100; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR034325; S-100_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR PANTHER; PTHR11639:SF73; PROTEIN S100-G; 1.
DR PANTHER; PTHR11639; S100 CALCIUM-BINDING PROTEIN; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF01023; S_100; 1.
DR SMART; SM00054; EFh; 1.
DR SMART; SM01394; S_100; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW Calcium; Metal-binding; Phosphoprotein; Reference proteome; Repeat;
KW Vitamin D.
FT CHAIN 1..79
FT /note="Protein S100-G"
FT /id="PRO_0000144028"
FT DOMAIN 13..48
FT /note="EF-hand 1"
FT /evidence="ECO:0000305"
FT DOMAIN 45..79
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 26
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="low affinity"
FT /evidence="ECO:0000305"
FT BINDING 31
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /ligand_note="low affinity"
FT /evidence="ECO:0000305"
FT BINDING 58
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 60
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 62
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 64
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 69
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /ligand_note="high affinity"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02634"
FT MOD_RES 47
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02634"
SQ SEQUENCE 79 AA; 8970 MW; 2272059DC925408F CRC64;
MCAEKSPAEM KSIFQKYAAK EGDPDQLSKE ELKLLIQSEF PSLLKASSTL DNLFKELDKN
GDGEVSYEEF EAFFKKLSQ
//
