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Database: UniProt
Entry: P98089
LinkDB: P98089
Original site: P98089 
ID   MUC2L_RAT               Reviewed;         837 AA.
AC   P98089;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   05-DEC-2018, entry version 88.
DE   RecName: Full=Intestinal mucin-like protein;
DE            Short=MLP;
DE   Flags: Fragment;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Intestine;
RX   PubMed=1371999;
RA   Xu G., Huan L.-J., Khatri I., Wang D., Bennick A., Fahim R.E.F.,
RA   Forstner G.G., Forstner J.F.;
RT   "cDNA for the carboxyl-terminal region of a rat intestinal mucin-like
RT   peptide.";
RL   J. Biol. Chem. 267:5401-5407(1992).
CC   -!- SUBUNIT: Multimeric.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Coats the epithelia of the intestines.
DR   EMBL; M81920; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; A42112; A42112.
DR   UniGene; Rn.217174; -.
DR   SMR; P98089; -.
DR   STRING; 10116.ENSRNOP00000064975; -.
DR   PaxDb; P98089; -.
DR   PRIDE; P98089; -.
DR   RGD; 1594023; LOC682824.
DR   eggNOG; KOG1216; Eukaryota.
DR   eggNOG; ENOG410XNSK; LUCA.
DR   HOVERGEN; HBG071087; -.
DR   InParanoid; P98089; -.
DR   PhylomeDB; P98089; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0070701; C:mucus layer; IEA:InterPro.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR028580; MUC2.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339:SF261; PTHR11339:SF261; 1.
DR   Pfam; PF08742; C8; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   Pfam; PF00094; VWD; 1.
DR   SMART; SM00832; C8; 1.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00214; VWC; 2.
DR   SMART; SM00216; VWD; 1.
DR   SUPFAM; SSF57567; SSF57567; 1.
DR   PROSITE; PS01185; CTCK_1; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 2.
DR   PROSITE; PS51233; VWFD; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Disulfide bond; Glycoprotein; Reference proteome;
KW   Repeat; Secreted.
FT   CHAIN        <1    837       Intestinal mucin-like protein.
FT                                /FTId=PRO_0000158959.
FT   REPEAT       17     27       1.
FT   REPEAT       28     38       2.
FT   REPEAT       39     50       3.
FT   REPEAT       51     62       4.
FT   REPEAT       63     70       5; truncated.
FT   DOMAIN      142    365       VWFD. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      472    543       VWFC 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN      581    648       VWFC 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN      732    817       CTCK. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00039}.
FT   REGION       17     70       5 X 11 AA approximate tandem repeats.
FT   REGION      149    837       Probably important for disulfide-bond
FT                                mediated mucin polymerization (link
FT                                domain).
FT   CARBOHYD     91     91       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    164    164       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    278    278       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    289    289       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    344    344       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    410    410       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    444    444       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    515    515       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    538    538       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    612    612       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    627    627       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    695    695       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    727    727       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    749    749       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    732    779       {ECO:0000250}.
FT   DISULFID    746    793       {ECO:0000250}.
FT   DISULFID    755    809       {ECO:0000250}.
FT   DISULFID    759    811       {ECO:0000250}.
FT   DISULFID      ?    816       {ECO:0000250}.
FT   NON_TER       1      1
SQ   SEQUENCE   837 AA;  91500 MW;  6335BCDCAC897F35 CRC64;
     VNCSVDCQLQ VFNWSCPSTP STPPPSTPTT PTSSQTTTPS TPSTTSSKST PSTPQSTSSK
     STPSTPPKTT LPGCLDFDPP RQVNETWWLC NCTMAICKYD NVVEIVELEC NPPPMPTCSN
     GLKPVRVPDP DGCCWHWECD CYCTGWGDPH FVTFDGLYYS YQGNCTYVLV EEITPTVDNF
     GVYIDNYHCD ANDKVSCPRT LIVHHETQEV LIKTVHMMPI EVEVQVNKQL VALPYKKYGL
     EVYQSGINFV VDIPRLGAQV SYNGLSFSIR LPYHLFGNNT KGQCGTCTNN TADDCILPSG
     EIISNCEVAA DEWLVNDPSK PHCPHKGLTT KRPAITTPGP FPENCTVSPV CQLIMDSLFS
     QCHPFVPPKH YYEACLFDSC FVAGSGMECA SVQAYAALCA QEGVCIDWRN HTQGACAVTC
     PAHRQYQACG PSEEPTCQSS SPKNSTLLVE GCFCPEGTTK FAPGYDVCVK ICGCVGPDNV
     PREFGEHFEF DCKDCVCLEG GSGIVCQPKK CARGNLTTCE EDGTYLVVEA DPDDKCCNTT
     SCKCDPKRCK AERPSCLLGF EVKSEHVPGK CCPVYSCVPK GVCVHENAEY QPGSPVYSNK
     CQDCVCTDSM DNSTQLNVIS CTHVPCNISC SSGFELVEVP GECCKKCQQT HCIIKRPEQQ
     YIILKPGEIQ KNPNDRCTFF SCMKINNQLI SSVSNITCPD FDPSDCVPGS ITYMPNGCCK
     TCIHNPNNTV PCSAIPVMKE ISYNGCAKNI SMNFCAGSCG TFAMYSAQAQ DLDHGCSCCR
     EERTSVRMVS LDCPDGSKLS HSYTHIESCL CQGTVCELPQ AQQSRTRRSS PRLLGRK
//
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