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Database: UniProt
Entry: P98153
LinkDB: P98153
Original site: P98153 
ID   IDD_HUMAN               Reviewed;         550 AA.
AC   P98153; A6NIB5; A8K6K5; B5TY34; B7Z935;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   05-JUN-2019, entry version 168.
DE   RecName: Full=Integral membrane protein DGCR2/IDD;
DE   Flags: Precursor;
GN   Name=DGCR2; Synonyms=IDD, KIAA0163;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Fetal brain;
RX   PubMed=7633403; DOI=10.1093/hmg/4.4.551;
RA   Demczuk S., Aledo R., Zucman J., Delattre O., Desmaze C.,
RA   Dauphinot L., Jalbert P., Rouleau G.A., Thomas G., Aurias A.;
RT   "Cloning of a balanced translocation breakpoint in the DiGeorge
RT   syndrome critical region and isolation of a novel potential adhesion
RT   receptor gene in its vicinity.";
RL   Hum. Mol. Genet. 4:551-558(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ALA-473.
RC   TISSUE=Brain;
RX   PubMed=7655455; DOI=10.1093/hmg/4.6.1027;
RA   Wadey R., Daw S., Taylor C., Atif U., Kamath S., Halford S.,
RA   O'Donnell H., Wilson D., Goodship J., Burn J., Scambler P.J.;
RT   "Isolation of a gene encoding an integral membrane protein from the
RT   vicinity of a balanced translocation breakpoint associated with
RT   DiGeorge syndrome.";
RL   Hum. Mol. Genet. 4:1027-1033(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RX   PubMed=19906316; DOI=10.1186/1471-2164-10-518;
RA   Wang P., Yu P., Gao P., Shi T., Ma D.;
RT   "Discovery of novel human transcript variants by analysis of intronic
RT   single-block EST with polyadenylation site.";
RL   BMC Genomics 10:518-518(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Bone marrow;
RX   PubMed=8724849; DOI=10.1093/dnares/3.1.17;
RA   Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N.;
RT   "Prediction of the coding sequences of unidentified human genes. V.
RT   The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by
RT   analysis of cDNA clones from human cell line KG-1.";
RL   DNA Res. 3:17-24(1996).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Placenta, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA   Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA   Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA   Beare D.M., Dunham I.;
RT   "A genome annotation-driven approach to cloning the human ORFeome.";
RL   Genome Biol. 5:R84.1-R84.11(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA   Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA   Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA   Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA   Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA   Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA   Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA   Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA   Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA   Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA   Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA   Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA   Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA   Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA   Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA   Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA   Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA   Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA   Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA   Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA   Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA   Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA   Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA   Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA   Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA   Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA   Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA   Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA   Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA   Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA   Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA   Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA   O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA   Khan A.S., Lane L., Tilahun Y., Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [10]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma, and Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: Putative adhesion receptor, that could be involved in
CC       cell-cell or cell-matrix interactions required for normal cell
CC       differentiation and migration.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P98153-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P98153-2; Sequence=VSP_042886;
CC         Note=No experimental confirmation available.;
CC       Name=3;
CC         IsoId=P98153-3; Sequence=VSP_057188, VSP_057189;
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in brain, heart, lung
CC       and fetal kidney. Low levels in liver and adult kidney.
DR   EMBL; X84076; CAA58883.1; -; mRNA.
DR   EMBL; X83545; CAA58536.1; -; mRNA.
DR   EMBL; L46352; AAB59561.1; -; mRNA.
DR   EMBL; D79985; BAA11480.1; -; mRNA.
DR   EMBL; FJ032369; ACI00235.1; -; mRNA.
DR   EMBL; AK291670; BAF84359.1; -; mRNA.
DR   EMBL; AK304382; BAH14171.1; -; mRNA.
DR   EMBL; CR456433; CAG30319.1; -; mRNA.
DR   EMBL; AC000095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471176; EAX03061.1; -; Genomic_DNA.
DR   EMBL; BC032430; AAH32430.1; -; mRNA.
DR   CCDS; CCDS33598.1; -. [P98153-1]
DR   CCDS; CCDS54496.1; -. [P98153-2]
DR   PIR; I37579; I37579.
DR   PIR; I84463; I84463.
DR   RefSeq; NP_001167004.1; NM_001173533.1. [P98153-2]
DR   RefSeq; NP_001167005.1; NM_001173534.1.
DR   RefSeq; NP_005128.1; NM_005137.2. [P98153-1]
DR   SMR; P98153; -.
DR   BioGrid; 115314; 11.
DR   IntAct; P98153; 2.
DR   MINT; P98153; -.
DR   STRING; 9606.ENSP00000263196; -.
DR   GlyConnect; 1404; -.
DR   iPTMnet; P98153; -.
DR   PhosphoSitePlus; P98153; -.
DR   BioMuta; DGCR2; -.
DR   DMDM; 1708396; -.
DR   EPD; P98153; -.
DR   jPOST; P98153; -.
DR   MaxQB; P98153; -.
DR   PaxDb; P98153; -.
DR   PeptideAtlas; P98153; -.
DR   PRIDE; P98153; -.
DR   ProteomicsDB; 57792; -.
DR   ProteomicsDB; 57793; -. [P98153-2]
DR   DNASU; 9993; -.
DR   Ensembl; ENST00000263196; ENSP00000263196; ENSG00000070413. [P98153-1]
DR   Ensembl; ENST00000537045; ENSP00000440062; ENSG00000070413. [P98153-2]
DR   GeneID; 9993; -.
DR   KEGG; hsa:9993; -.
DR   UCSC; uc062bkk.1; human. [P98153-1]
DR   CTD; 9993; -.
DR   DisGeNET; 9993; -.
DR   GeneCards; DGCR2; -.
DR   GeneReviews; DGCR2; -.
DR   HGNC; HGNC:2845; DGCR2.
DR   HPA; HPA000873; -.
DR   HPA; HPA075929; -.
DR   MalaCards; DGCR2; -.
DR   MIM; 600594; gene.
DR   neXtProt; NX_P98153; -.
DR   OpenTargets; ENSG00000070413; -.
DR   PharmGKB; PA27307; -.
DR   eggNOG; ENOG410IPT1; Eukaryota.
DR   eggNOG; ENOG4110Q97; LUCA.
DR   GeneTree; ENSGT00390000017655; -.
DR   HOGENOM; HOG000112997; -.
DR   InParanoid; P98153; -.
DR   OrthoDB; 491327at2759; -.
DR   PhylomeDB; P98153; -.
DR   TreeFam; TF330997; -.
DR   ChiTaRS; DGCR2; human.
DR   GeneWiki; DGCR2; -.
DR   GenomeRNAi; 9993; -.
DR   PRO; PR:P98153; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   Bgee; ENSG00000070413; Expressed in 240 organ(s), highest expression level in amniotic fluid.
DR   ExpressionAtlas; P98153; baseline and differential.
DR   Genevisible; P98153; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0009887; P:animal organ morphogenesis; TAS:ProtInc.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0050890; P:cognition; IMP:UniProtKB.
DR   CDD; cd03599; CLECT_DGCR2_like; 1.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   Gene3D; 4.10.400.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR034010; DGCR2-like_CTLD.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM00214; VWC; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   SUPFAM; SSF57424; SSF57424; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS01208; VWFC_1; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell adhesion; Complete proteome;
KW   Disulfide bond; Glycoprotein; Lectin; Membrane; Phosphoprotein;
KW   Polymorphism; Receptor; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21    550       Integral membrane protein DGCR2/IDD.
FT                                /FTId=PRO_0000021484.
FT   TOPO_DOM     21    349       Extracellular. {ECO:0000255}.
FT   TRANSMEM    350    368       Helical. {ECO:0000255}.
FT   TOPO_DOM    369    550       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       28     68       LDL-receptor class A.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      115    241       C-type lectin. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00040}.
FT   DOMAIN      270    333       VWFC.
FT   MOD_RES     381    381       Phosphoserine.
FT                                {ECO:0000244|PubMed:23186163}.
FT   CARBOHYD    149    149       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    196    196       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     30     44       {ECO:0000250}.
FT   DISULFID     37     57       {ECO:0000250}.
FT   DISULFID     51     66       {ECO:0000250}.
FT   DISULFID    145    265       {ECO:0000250}.
FT   DISULFID    233    257       {ECO:0000250}.
FT   VAR_SEQ      26     66       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_042886.
FT   VAR_SEQ     315    327       QGCQQYRKDPKEC -> HGCSPLSCTARAT (in
FT                                isoform 3).
FT                                {ECO:0000303|PubMed:19906316}.
FT                                /FTId=VSP_057188.
FT   VAR_SEQ     328    550       Missing (in isoform 3).
FT                                {ECO:0000303|PubMed:19906316}.
FT                                /FTId=VSP_057189.
FT   VARIANT     473    473       V -> A (in dbSNP:rs2072123).
FT                                {ECO:0000269|PubMed:7655455}.
FT                                /FTId=VAR_020046.
SQ   SEQUENCE   550 AA;  60811 MW;  770204F2F36A8AAC CRC64;
     MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ CDGWATCEDE
     SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV NVAQPVRFSS FLGKCPTGWH
     HYEGTASCYR VYLSGENYWD AAQTCQRLNG SLATFSTDQE LRFVLAQEWD QPERSFGWKD
     QRKLWVGYQY VITGRNRSLE GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH
     FPTLRHHDLH SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG
     GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL VVSCISSFLI
     LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD YGPDGFGTGL TPLHLSDDGE
     GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP YEASIHPDSV FYDPADDDAF EPVEVSLPAP
     GDGGSEGALL RRLEQPLPTA GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR
     HSRSSLNTVV
//
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