GenomeNet

Database: UniProt
Entry: P98167
LinkDB: P98167
Original site: P98167 
ID   SSPO_BOVIN              Reviewed;        5146 AA.
AC   P98167; Q8SPM4;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   16-JAN-2019, entry version 129.
DE   RecName: Full=SCO-spondin;
DE   Flags: Precursor;
GN   Name=SSPO;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Subcommissural organ;
RX   PubMed=11008217;
RX   DOI=10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V;
RA   Gobron S.;
RT   "Subcommissural organ/Reissner's fiber complex: characterization of
RT   SCO-spondin, a glycoprotein with potent activity on neurite
RT   outgrowth.";
RL   Glia 32:177-191(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1719-2585.
RC   TISSUE=Ependymocyte;
RX   PubMed=8743952;
RA   Gobron S., Monnerie H., Meiniel R., Creveaux I., Lehmann W.,
RA   Lamalle D., Dastugue B., Meiniel A.;
RT   "SCO-spondin: a new member of the thrombospondin family secreted by
RT   the subcommissural organ is a candidate in the modulation of neuronal
RT   aggregation.";
RL   J. Cell Sci. 109:1053-1061(1996).
CC   -!- FUNCTION: Involved in the modulation of neuronal aggregation. May
CC       be involved in developmental events during the formation of the
CC       central nervous system.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- TISSUE SPECIFICITY: Subcommissural organ. Located at the boundary
CC       of the diencephalon and mesencephalon beneath the posterior
CC       commissure at the point where the axons cross the midline.
CC       {ECO:0000269|PubMed:11008217}.
CC   -!- DEVELOPMENTAL STAGE: Embryo.
CC   -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
DR   EMBL; AJ416457; CAC94914.1; -; mRNA.
DR   EMBL; X93922; CAA63815.1; -; mRNA.
DR   RefSeq; NP_777131.1; NM_174706.2.
DR   UniGene; Bt.4812; -.
DR   ProteinModelPortal; P98167; -.
DR   STRING; 9913.ENSBTAP00000041504; -.
DR   MEROPS; I08.954; -.
DR   PaxDb; P98167; -.
DR   PRIDE; P98167; -.
DR   GeneID; 282659; -.
DR   KEGG; bta:282659; -.
DR   CTD; 23145; -.
DR   eggNOG; KOG1215; Eukaryota.
DR   eggNOG; KOG1216; Eukaryota.
DR   eggNOG; KOG4475; Eukaryota.
DR   eggNOG; ENOG410XNSK; LUCA.
DR   HOGENOM; HOG000154433; -.
DR   HOVERGEN; HBG080794; -.
DR   InParanoid; P98167; -.
DR   OrthoDB; 12226at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   CDD; cd00057; FA58C; 1.
DR   CDD; cd00112; LDLa; 9.
DR   Gene3D; 2.20.100.10; -; 25.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR036201; Pacifastin_dom_sf.
DR   InterPro; IPR030119; SCO-spondin.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339:SF358; PTHR11339:SF358; 14.
DR   Pfam; PF08742; C8; 3.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF00057; Ldl_recept_a; 8.
DR   Pfam; PF01826; TIL; 11.
DR   Pfam; PF00090; TSP_1; 22.
DR   Pfam; PF00093; VWC; 1.
DR   Pfam; PF00094; VWD; 3.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00832; C8; 3.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00192; LDLa; 10.
DR   SMART; SM00209; TSP1; 25.
DR   SMART; SM00214; VWC; 5.
DR   SMART; SM00215; VWC_out; 9.
DR   SMART; SM00216; VWD; 3.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF57283; SSF57283; 1.
DR   SUPFAM; SSF57424; SSF57424; 9.
DR   SUPFAM; SSF57567; SSF57567; 14.
DR   SUPFAM; SSF82895; SSF82895; 24.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS01209; LDLRA_1; 7.
DR   PROSITE; PS50068; LDLRA_2; 9.
DR   PROSITE; PS50092; TSP1; 25.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 2.
DR   PROSITE; PS51233; VWFD; 3.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Complete proteome; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL        1     17       {ECO:0000255}.
FT   CHAIN        18   5146       SCO-spondin.
FT                                /FTId=PRO_0000186461.
FT   DOMAIN       18     94       EMI.
FT   DOMAIN      186    392       VWFD 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      464    519       TIL 1.
FT   DOMAIN      558    768       VWFD 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      822    875       TIL 2.
FT   DOMAIN     1009   1215       VWFD 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN     1271   1327       TIL 3.
FT   DOMAIN     1372   1409       LDL-receptor class A 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1412   1447       LDL-receptor class A 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1448   1484       LDL-receptor class A 3.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1488   1526       LDL-receptor class A 4.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1561   1597       LDL-receptor class A 5.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1599   1638       LDL-receptor class A 6.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1652   1690       LDL-receptor class A 7.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1691   1745       TSP type-1 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1747   1805       TSP type-1 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1821   1860       EGF-like 1.
FT   DOMAIN     1861   1898       EGF-like 2.
FT   DOMAIN     1906   1962       TSP type-1 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1962   2022       VWFC 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     2062   2220       F5/8 type C. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00081}.
FT   DOMAIN     2225   2261       LDL-receptor class A 8.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2382   2418       LDL-receptor class A 9.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2442   2478       LDL-receptor class A 10.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2479   2532       TSP type-1 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2534   2589       TSP type-1 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2612   2654       TIL 4.
FT   DOMAIN     2694   2748       TSP type-1 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2751   2807       TSP type-1 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2809   2862       TSP type-1 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2964   3019       TSP type-1 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3020   3071       TSP type-1 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3163   3230       TSP type-1 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3232   3287       TSP type-1 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3291   3345       TIL 5.
FT   DOMAIN     3388   3450       TSP type-1 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3452   3507       TSP type-1 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3626   3674       TSP type-1 15. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3802   3858       TSP type-1 16. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3872   3924       TSP type-1 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3938   3994       TSP type-1 18. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3996   4051       TSP type-1 19. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4101   4168       VWFC 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     4151   4204       TSP type-1 20. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4245   4300       TSP type-1 21. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4302   4358       TSP type-1 22. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4360   4414       TSP type-1 23. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4610   4661       TSP type-1 24. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4761   4814       TSP type-1 25. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4816   4870       TIL 6.
FT   DOMAIN     4983   5041       VWFC 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     5052   5139       CTCK. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00039}.
FT   COMPBIAS    523    527       Poly-Arg.
FT   CARBOHYD     80     80       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    122    122       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    153    153       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    255    255       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    814    814       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    906    906       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1349   1349       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1647   1647       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1806   1806       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2027   2027       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2127   2127       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2624   2624       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2673   2673       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2915   2915       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2946   2946       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3041   3041       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3143   3143       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3153   3153       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3290   3290       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3502   3502       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3580   3580       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3607   3607       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3783   3783       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3906   3906       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3938   3938       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4131   4131       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4341   4341       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4412   4412       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4729   4729       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4746   4746       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4751   4751       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4772   4772       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4861   4861       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4901   4901       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4947   4947       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4954   4954       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5060   5060       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID   1373   1386       {ECO:0000250}.
FT   DISULFID   1380   1399       {ECO:0000250}.
FT   DISULFID   1393   1408       {ECO:0000250}.
FT   DISULFID   1413   1425       {ECO:0000250}.
FT   DISULFID   1420   1438       {ECO:0000250}.
FT   DISULFID   1432   1447       {ECO:0000250}.
FT   DISULFID   1449   1461       {ECO:0000250}.
FT   DISULFID   1456   1474       {ECO:0000250}.
FT   DISULFID   1468   1483       {ECO:0000250}.
FT   DISULFID   1489   1501       {ECO:0000250}.
FT   DISULFID   1496   1514       {ECO:0000250}.
FT   DISULFID   1508   1525       {ECO:0000250}.
FT   DISULFID   1562   1574       {ECO:0000250}.
FT   DISULFID   1569   1587       {ECO:0000250}.
FT   DISULFID   1581   1596       {ECO:0000250}.
FT   DISULFID   1600   1613       {ECO:0000250}.
FT   DISULFID   1607   1626       {ECO:0000250}.
FT   DISULFID   1620   1637       {ECO:0000250}.
FT   DISULFID   1653   1663       {ECO:0000250}.
FT   DISULFID   1658   1676       {ECO:0000250}.
FT   DISULFID   1670   1691       {ECO:0000250}.
FT   DISULFID   1703   1739       {ECO:0000250}.
FT   DISULFID   1707   1744       {ECO:0000250}.
FT   DISULFID   1718   1729       {ECO:0000250}.
FT   DISULFID   1825   1840       {ECO:0000250}.
FT   DISULFID   1834   1845       {ECO:0000250}.
FT   DISULFID   1847   1859       {ECO:0000250}.
FT   DISULFID   1865   1884       {ECO:0000250}.
FT   DISULFID   1867   1887       {ECO:0000250}.
FT   DISULFID   1889   1897       {ECO:0000250}.
FT   DISULFID   1907   1946       {ECO:0000250}.
FT   DISULFID   1918   1922       {ECO:0000250}.
FT   DISULFID   1956   1961       {ECO:0000250}.
FT   DISULFID   2062   2220       {ECO:0000250}.
FT   DISULFID   2226   2238       {ECO:0000250}.
FT   DISULFID   2233   2251       {ECO:0000250}.
FT   DISULFID   2245   2260       {ECO:0000250}.
FT   DISULFID   2383   2395       {ECO:0000250}.
FT   DISULFID   2390   2408       {ECO:0000250}.
FT   DISULFID   2402   2417       {ECO:0000250}.
FT   DISULFID   2443   2455       {ECO:0000250}.
FT   DISULFID   2450   2468       {ECO:0000250}.
FT   DISULFID   2462   2477       {ECO:0000250}.
FT   DISULFID   2480   2516       {ECO:0000250}.
FT   DISULFID   2491   2495       {ECO:0000250}.
FT   DISULFID   2526   2531       {ECO:0000250}.
FT   DISULFID   2546   2583       {ECO:0000250}.
FT   DISULFID   2550   2588       {ECO:0000250}.
FT   DISULFID   2561   2573       {ECO:0000250}.
FT   DISULFID   2695   2733       {ECO:0000250}.
FT   DISULFID   2706   2710       {ECO:0000250}.
FT   DISULFID   2743   2747       {ECO:0000250}.
FT   DISULFID   2763   2801       {ECO:0000250}.
FT   DISULFID   2767   2806       {ECO:0000250}.
FT   DISULFID   2783   2791       {ECO:0000250}.
FT   DISULFID   2821   2856       {ECO:0000250}.
FT   DISULFID   2825   2861       {ECO:0000250}.
FT   DISULFID   2836   2846       {ECO:0000250}.
FT   DISULFID   2965   3003       {ECO:0000250}.
FT   DISULFID   2976   2980       {ECO:0000250}.
FT   DISULFID   3013   3018       {ECO:0000250}.
FT   DISULFID   3175   3224       {ECO:0000250}.
FT   DISULFID   3179   3229       {ECO:0000250}.
FT   DISULFID   3190   3214       {ECO:0000250}.
FT   DISULFID   3244   3281       {ECO:0000250}.
FT   DISULFID   3248   3286       {ECO:0000250}.
FT   DISULFID   3259   3271       {ECO:0000250}.
FT   DISULFID   3400   3443       {ECO:0000250}.
FT   DISULFID   3404   3449       {ECO:0000250}.
FT   DISULFID   3415   3427       {ECO:0000250}.
FT   DISULFID   3464   3499       {ECO:0000250}.
FT   DISULFID   3467   3506       {ECO:0000250}.
FT   DISULFID   3477   3489       {ECO:0000250}.
FT   DISULFID   3638   3668       {ECO:0000250}.
FT   DISULFID   3642   3673       {ECO:0000250}.
FT   DISULFID   3653   3658       {ECO:0000250}.
FT   DISULFID   3814   3852       {ECO:0000250}.
FT   DISULFID   3818   3857       {ECO:0000250}.
FT   DISULFID   3830   3842       {ECO:0000250}.
FT   DISULFID   3939   3975       {ECO:0000250}.
FT   DISULFID   3950   3954       {ECO:0000250}.
FT   DISULFID   3988   3993       {ECO:0000250}.
FT   DISULFID   4008   4045       {ECO:0000250}.
FT   DISULFID   4012   4050       {ECO:0000250}.
FT   DISULFID   4023   4035       {ECO:0000250}.
FT   DISULFID   4152   4188       {ECO:0000250}.
FT   DISULFID   4163   4167       {ECO:0000250}.
FT   DISULFID   4198   4203       {ECO:0000250}.
FT   DISULFID   4257   4294       {ECO:0000250}.
FT   DISULFID   4261   4299       {ECO:0000250}.
FT   DISULFID   4272   4284       {ECO:0000250}.
FT   DISULFID   4361   4398       {ECO:0000250}.
FT   DISULFID   4372   4374       {ECO:0000250}.
FT   DISULFID   4408   4413       {ECO:0000250}.
FT   DISULFID   4611   4645       {ECO:0000250}.
FT   DISULFID   4622   4626       {ECO:0000250}.
FT   DISULFID   4655   4660       {ECO:0000250}.
FT   DISULFID   4773   4808       {ECO:0000250}.
FT   DISULFID   4777   4813       {ECO:0000250}.
FT   DISULFID   4788   4797       {ECO:0000250}.
FT   DISULFID   5052   5100       {ECO:0000250}.
FT   DISULFID   5066   5117       {ECO:0000250}.
FT   DISULFID   5076   5133       {ECO:0000250}.
FT   DISULFID   5080   5135       {ECO:0000250}.
FT   DISULFID      ?   5138       {ECO:0000250}.
SQ   SEQUENCE   5146 AA;  543593 MW;  724C5FB8727E13DA CRC64;
     MLLPALLFGA AWALANGRWC EQTETVLVEE EVTPHQEDLV PCASLQHYQR RGWRLDLTWS
     GRAGLCAIYK PPETRPAAWN RTVRACCPGW GGTHCTLALA EASPEGHCFA TWLCNLGAGS
     VNASAGSLEE CCAQPWGHSW RDGRSQTCHS CSNHSRLGST PSPAILQPLA GAVAQLWSQR
     QRPSATCATW SGFHYRTFDG RHFHFLGRCT YLLAGAADAT WAVHLQPMGH CPQPGHCQLA
     RVMMGPEEVL IRGENVTVNG RLVPEGASQL LPGLSLQWQG DWLVLSGGLG VVVRLDRSSS
     VSISVDQELQ GQTQGLCGVY NGQPEDDFLE PGRGLAALAA TFGNSWRLPD SELGCLDAVE
     AAQGCEDPLR GTETGTEAGQ LRAEAQDVCH QLLEGPFREC HTQVPPAEYH EACLFAYCAG
     APAGSGRAER LEAVCATLAS YAQDCAARRI AVRWRKPGFC ERLCPGGQLY SDCASACPPS
     CSAVGEGSEW SCGEECVSGC ECPPGLFWDG ALCVPAARCP CYRRRRRYEP GDTVRQLCNP
     CECRDGRWLC AQAPCAAECA VGGDGHYVTF DGRSFSFRGR AGCRFILVQD FAKRQLLIVL
     EHGDCDAGSC LHAISVSLGD TLVQLRDSGV VLVDGQDVAL PWSAAGGLSV SRASSSFLLL
     RWPGARILWG VSDPAAYITL DPHHAHQVQG LCGTFTRNQQ DDFLTPAGDV ETSITAFASK
     FQVAGGGTCS LEACTPLSPC STHTERQVFA EVACAILHGP TFQECHGLVD REAFHLRCLA
     AVCGCTPGRD CLCPVLAAYA RRCAQEGALP SWRNQTFCPV LCPGGQEYQE CAPACDRNCG
     EPEDCGELDN CVAGCNCPLG LLWDPEGQCV PPNLCPCQLG AHRYAPGSAT MKDCNHCVCQ
     ERGLWNCTAH HCAPPRTFCP RELVYVPGAC LLTCDSLDAD RTCPPGSPGG CVCPPGTVLL
     EERCVPPELC PCRHGGQWYL PNAAIQEDCN LCVCQGQQWH CTGQRCDGRC RASGAPHYVT
     FDGLALTFPG ACEYLLVREA SGQFMVSAQN LPCGASGLTC TKALTVRLQG TVVHMLRGRA
     VMVNGVSVTP PKVYSGPGLS LHTAGLFLLL STRLGLTLLW DGGTRVPVQL SPQLRGRVAG
     LCGDFDGDAS NDLRSRQGVL EPTAELAAHS WRLGPLCPEP GDLPHPCAVN AHRAGWARAR
     CGVVLQPLFA RCHVEVPPQQ HYEQCVYDAC GCDSGGDCEC LCSAIATYAD ECARHGIHVR
     WRSQELCPLQ CERGQVYEAC GPTCPATCHD HRPEPGWPCR AVACVEGCFC PEGTLLHGGV
     CLEPAACPCE WGGSFFPPGT VLQKDCGNNC TCRESQWLCG DDGGRCVEPG PGCAEGETPC
     RESGHCVPHG WLCDNQDDCG DGSDEEGCAT RVCGEGQVSC CSGRCLPLVL LCDGQDDCGD
     GMDEQGCPCP QDSLTCADGH CLPPARLCDG HPDCPDGADE ESCLGQVDCA PGEVSCVDGT
     CLGAIQLCDG VWDCLDGGDE GPGHCPLPSL PTPPAGTLPG PSAVSWKLHL PPWPVSALRL
     PCGPLDFACG SGECAPRGWR CDGEEDCADG SDESGCDRPC APHHAPCARG SHCVAAEQLC
     DGVPHCPDGS DEDPGACERL QAPGGPNRTG LPCPEYSCPD GLCIGFQQVC DGQPDCELAG
     TAGPSPEEQG CGAWGPWSPW ELCSRTCGPG VQGWSRRCSP PSLPVLWHCP GPERQTRACF
     AAACPEDGVW TSWSRWSPCS EPCGGVTARH RECHPPQNGG RTCATLPGGP PSTRETRPCP
     QDGCPNVTCS GELVFHACVP CPLTCDDISG QATCPPDRPC GGPGCWCPAG QVLGAQGRCV
     WPRQCPCLVD GSRYWPGQRV KTDCQLCVCQ DGRPRRCQPS LDCAVNCGWS AWSPWAECLG
     PCGSRSVQWS FRSPNNPRPA GRGHQCRGLH RKARRCQTEP CEGCEQDGRV HRVGERWRAG
     PCRVCQCLHD GSARCSPYCP LGSCPQDWVL VEGVGESCCH CVPPGENQTV HPMATPVPAP
     TPSPQIGAPL ITYLLPPPGD PCYSPLGLAR LPEGSLPASS QQLEHPAWAA ILRPAPGAPG
     WSPVEHADTQ GHTPPPYLQL DLLQPRNLTG IIVQGAGSSD WLQVSSDGLH WHSYRDIQHG
     TQPAPQLFPK NWNGPSTVWM FARMVQARHV RVWPSDGHHQ AAPSSDANLD GPLRVELLGC
     EPAPLCLGVG HRCVSGECAP RGAPCDGVED CKDGSDEEGC VTPPAGAGRI ESTAWSSAPS
     SAQPGQLPPQ PSEGLAEAEA DHWHPGRGSP VPPTGKGPAS LGSEPHPSPG GSVQTVTPTS
     QPEAQALRPE MAAVTVLPPH PMVTPEVPAG RSTTPGPFPH VQCSPGQVPC EVLGCVELEQ
     LCDGREDCLD GSDERPCAWA AGTVPFTVPT TTLPGLPASR DLCSPSQLTC GSGECLPVER
     RCDLQLDCQD GSDENGCVDC GLAPWSGWSS CSRSCGLGLA FQRRELLRPP LPGGSCPPDR
     LRSQPCFVQA CPVAGAWAEW EAWGPCSVSC GGGHRSRRRS CMDPPPKNGG APCPGPPQER
     APCGLQPCAG GTDCGQGRVH VSAELCRKGL VPPCPPSCLD PEANRSCSGL CLEGCRCPPG
     LLLQDAGCLP LSECPCLVGE ELQQPGVPFL LDNCSRCVCE KGALLCEPGG CPVPCGWSAW
     SSWGPCDRSC GSGLRARFRS PSNPPAASGG APCEGQRQEL QACYSACGAE VPGWTPWAPW
     SACSQSCLVP GGGPALRSRS RLCPGPGDTS CIGEATEEEP CSPPVCLGLG VWGQWAAWSA
     CSAPCNGGVQ TRGRRCSASA PGDPGCQGPH SQTRDCNTQP CTAQCPGDMV FRSAEQCRWE
     GGPCPGLCLA RGPGVECTGV CTAGCACPTG LFLHNSSCLP PSQCPCQLRG QLYAPGAVAR
     LDSCSNCTCI SGEMVCASEP CPVACGWSPW TPWSLCSRSC NVGVRRRFRA GTAPPAAFGG
     AACQGPNMEA EFCSLRPCGG PAGEWGPWSP CSVPCGGGYR NRTRGSSGPS PVDFSTCGLQ
     PCAGPAPGVC PPGKRWLDCA QGPASCAELS APRGADQPCH PGCYCPSGML LLNNACVPTQ
     DCPCTHGGRL HPPGSAVLRP CENCSCVSGL ITNCTSWPCK EGQPTWSPWT PWSECSASCG
     PARRHKHRFC TRPPGGAPSS MAPPLLLSSV PPLCPGPEAE EEPCLLPECD RAGGWGPWGP
     WSSCSRSCGG GLRSRSRACD QPPPQGLGDY CEGPRAQGAA CQALPCPVTN CTAIEGAEYS
     ACGPPCPRSC DDLVHCVWHC QPGCYCPPGQ VLSADGTVHV QPGHCSCLDL LTGERHRPGA
     QLAKPDGCNY CTCSEGQLTC TDLPCPVPGA WCPWSEWTAC SQPCQGQTRT RSRACSCPAP
     QHGGAPCPGE AGEAGAQHQR ETCASTPECP VDGAWSPWGP WSPCEVCLGR SHRSRECSWP
     PTSEGGRPCP GGHRQSRPCQ GNSTQCTDCA GGQDLLPCGQ PCPRSCEDLS PGVECQPDSM
     GCQQPRCGCP PGQLSQDGLC VTPSQCRCQY QPGAMGIPEN QSRSAGSGLS SWESLEPGEV
     VTGPCDNCTC VAGILQCQEV PACSGLGLWG SWGPWEDCSV SCGGGEQLRF RRCPRPPCPG
     PARQSRTCRT QVCREAGCPA GRLYRECQPS EGCPFSCAHV TGQVGCFSAG CEEGCHCPEG
     TFLHRSACVQ ECPCVLTALW LQGLGAAGAD PGAHLSVLGE NGQPLGPGDE LGSGQSLRTG
     CHNCSCAHGK LSCSVEACSK AAGGFSPWGP WGPCSRSCGG LGTRTRSRQC VRPMPAPGGQ
     GCHGPHWDLE YCPSPECPGA AGSTAEPATG LPGGWGLWSP WSPCSGTCTD PAHPAWRSRS
     RLCLANCTGG AASQERPCNL PSCTELPLCP GPGCEAGNCS WTAWAPWEPC SRSCGVGQQR
     RLRAYHPPGP GGHWCPDVLT AYQERRFCNL RACPVPGGWS RWSPWSWCDR SCGGGRSLRS
     RSCSSPPPKN GGAPCVGERH HARLCNPTPC EEGCPAGMEV VSCANRCPRR CSDLQEGIVC
     QEDQACQQGC RCPEGSLEQD GGCVPLGHCE CTDAQGHSWA PGSQHQEACN NCTCRAGQLS
     CTAQPCPPPA HCAWSRWSAW SPCSRSCGPA GQQSRFRSST SGSWAPECRE EQSQSQPCPQ
     SPCPPLCLQG TRPRSLGDSW LQDGCQQCSC TPEGIICEDA ECAGLGAWTP WSPWSDCPVS
     CGGGNQVRTR VCVASAPPRG GSPCLGPDVQ SQRCGLWPCP ALPDTCSWGP WGPCSRSCGP
     GLASRSASCP CLLAEAEPAC NSTSPRLDTQ ACYAGPCLEE CVWSSWSSWT RCSCEVLVQQ
     RYRHQRPAPG GAGAGPPCTR LDGHFRPCLT GNCSEDSCAP PFEFQACGSP CTGLCATYLS
     PWLCQDLPPC QPGCYCPEGL LEQAGGCVPP EQCNCQHVSG EGAGVTLAPG DRLQLGCKEC
     ECQRGELQCT SQGCQGLLPL SGWSEWSPCG PCLPLGLLAP ASRAALEERW PQDTAGLSPT
     SAPTLASEQH RHRLCLDPET GRPWAGDPDL CTVPLSQQRL CPDPGACQDL CQWGPWGAWS
     PCQVPCSGGF RLRWREAGIP PGGGCRGPWA QTESCNMGPC PGESCEAQDT VPTPDCANQC
     PRSCVDLWDR VECLQGPCRP GCRCPPGQLV QDGHCVPVSS CRCGLPSPNA SWALAPAEVV
     RLDCRNCTCV NGSLACSSHE CPTLGPWSAW SNCSAPCGGG TTKRHRSCKE GPGVTPCQAQ
     DMEQQQDCNL QPCPECPPGQ VLSACAVSCP RLCSHLQPGT PCMQEPCQLG CDCPRGQLLH
     NGTCVPPAEC PCTQLSLPWG LTLTLEEQHR ELPPGTLLTQ NCTHCICQGG AFSCSLTDCQ
     ECPPGETWQQ VAPGELGPCE QTCREPNATE TQGNCSGRQA PGCVCQRGHF RSQEGPCVPV
     DLCECWHHGR PHPPGSEWQK ACESCRCVSG ESICTQHCPP LTCAQGETAV QEPGGCCPTC
     RQEAPEEQPV SCRHLTELRN LTKGACYLEQ VEVNYCSGHC PSSTNVLPEE PYLQSQCDCC
     SYRLDPENPV RILNLRCPGG RTELVVLPVI HSCQCSACQG GDFSER
//
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