ID ZXDB_HUMAN Reviewed; 803 AA.
AC P98169; A8K151; Q9UBB3;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 27-MAR-2024, entry version 177.
DE RecName: Full=Zinc finger X-linked protein ZXDB;
GN Name=ZXDB;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 307-709, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=8268913; DOI=10.1093/hmg/2.10.1611;
RA Greig G.M., Sharp C.B., Carrel L., Willard H.F.;
RT "Duplicated zinc finger protein genes on the proximal short arm of the
RT human X chromosome: isolation, characterization and X-inactivation
RT studies.";
RL Hum. Mol. Genet. 2:1611-1618(1993).
CC -!- FUNCTION: Cooperates with CIITA to promote transcription of MHC class I
CC and MHC class II genes. {ECO:0000250}.
CC -!- SUBUNIT: Self-associates. Interacts with ZXDC and CIITA (By
CC similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC P98169; P38919: EIF4A3; NbExp=3; IntAct=EBI-17493569, EBI-299104;
CC P98169; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-17493569, EBI-14096082;
CC P98169; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-17493569, EBI-10183064;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: May be expressed in brain, heart, kidney, liver,
CC lung, muscle and placenta. {ECO:0000269|PubMed:8268913}.
CC -!- SIMILARITY: Belongs to the ZXD family. {ECO:0000305}.
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DR EMBL; AK289766; BAF82455.1; -; mRNA.
DR EMBL; AL031115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z99130; CAB16205.1; -; Genomic_DNA.
DR EMBL; CH471154; EAW93246.1; -; Genomic_DNA.
DR EMBL; L14788; AAC37522.1; -; mRNA.
DR CCDS; CCDS35313.1; -.
DR PIR; I54340; I54340.
DR RefSeq; NP_009088.1; NM_007157.3.
DR AlphaFoldDB; P98169; -.
DR SMR; P98169; -.
DR BioGRID; 127694; 19.
DR IntAct; P98169; 3.
DR STRING; 9606.ENSP00000364023; -.
DR iPTMnet; P98169; -.
DR PhosphoSitePlus; P98169; -.
DR BioMuta; ZXDB; -.
DR DMDM; 12644370; -.
DR EPD; P98169; -.
DR jPOST; P98169; -.
DR MassIVE; P98169; -.
DR MaxQB; P98169; -.
DR PaxDb; 9606-ENSP00000364023; -.
DR PeptideAtlas; P98169; -.
DR ProteomicsDB; 57802; -.
DR Antibodypedia; 77180; 6 antibodies from 5 providers.
DR DNASU; 158586; -.
DR Ensembl; ENST00000374888.3; ENSP00000364023.1; ENSG00000198455.5.
DR GeneID; 158586; -.
DR KEGG; hsa:158586; -.
DR MANE-Select; ENST00000374888.3; ENSP00000364023.1; NM_007157.4; NP_009088.1.
DR UCSC; uc004dvd.4; human.
DR AGR; HGNC:13199; -.
DR CTD; 158586; -.
DR GeneCards; ZXDB; -.
DR HGNC; HGNC:13199; ZXDB.
DR HPA; ENSG00000198455; Low tissue specificity.
DR MIM; 300236; gene.
DR neXtProt; NX_P98169; -.
DR OpenTargets; ENSG00000198455; -.
DR PharmGKB; PA37764; -.
DR VEuPathDB; HostDB:ENSG00000198455; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164739; -.
DR HOGENOM; CLU_007312_0_0_1; -.
DR InParanoid; P98169; -.
DR OMA; PGCAWAF; -.
DR OrthoDB; 2899328at2759; -.
DR PhylomeDB; P98169; -.
DR TreeFam; TF330996; -.
DR PathwayCommons; P98169; -.
DR SignaLink; P98169; -.
DR BioGRID-ORCS; 158586; 13 hits in 724 CRISPR screens.
DR ChiTaRS; ZXDB; human.
DR GenomeRNAi; 158586; -.
DR Pharos; P98169; Tdark.
DR PRO; PR:P98169; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; P98169; Protein.
DR Bgee; ENSG00000198455; Expressed in germinal epithelium of ovary and 155 other cell types or tissues.
DR Genevisible; P98169; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 9.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR46179; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR46179:SF6; ZINC FINGER X-LINKED PROTEIN ZXDB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW Activator; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..803
FT /note="Zinc finger X-linked protein ZXDB"
FT /id="PRO_0000047777"
FT ZN_FING 271..295
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 304..328
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 334..358
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 364..386
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..417
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..448
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 454..478
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 484..508
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 514..538
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 547..572
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..577
FT /note="Required for interaction with ZXDC"
FT /evidence="ECO:0000250"
FT REGION 576..703
FT /note="Required for transcriptional activation"
FT /evidence="ECO:0000250"
FT COMPBIAS 232..246
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 736
FT /note="A -> T (in dbSNP:rs1057338)"
FT /id="VAR_033003"
FT VARIANT 760
FT /note="N -> S (in dbSNP:rs1057340)"
FT /id="VAR_033004"
FT VARIANT 764
FT /note="D -> N (in dbSNP:rs1057341)"
FT /id="VAR_033005"
FT VARIANT 791
FT /note="T -> R (in dbSNP:rs1057343)"
FT /id="VAR_033006"
SQ SEQUENCE 803 AA; 84792 MW; FD5A6D326FF5A5D4 CRC64;
MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLLRGP QDGGPGRRRE
EASTASRGPG PSLLAPRTDQ PSGGGGGGGD DFFLVLLDPV GGDVETAGSG QAAGPVLREE
AEEGPGLQGG ESGANPAGPT ALGPRCLSAV PTPAPISAPG PAAAFAGTVT IHNQDLLLRF
ENGVLTLATP PPHAWEPGAA PAQQPGCLIA PQAGFPHAAH PGDCPELPPD LLLAEPAEPA
PAPAPEEEAE GPAAALGPRG PLGSGPGVVL YLCPEAQCGQ TFAKKHQLKV HLLTHSSSQG
QRPFKCPLGG CGWTFTTSYK LKRHLQSHDK LRPFGCPAEG CGKSFTTVYN LKAHMKGHEQ
ENSFKCEVCE ESFPTQAKLS AHQRSHFEPE RPYQCAFSGC KKTFITVSAL FSHNRAHFRE
QELFSCSFPG CSKQYDKACR LKIHLRSHTG ERPFLCDFDG CGWNFTSMSK LLRHKRKHDD
DRRFMCPVEG CGKSFTRAEH LKGHSITHLG TKPFVCPVAG CCARFSARSS LYIHSKKHLQ
DVDTWKSRCP ISSCNKLFTS KHSMKTHMVK RHKVGQDLLA QLEAANSLTP SSELTSQRQN
DLSDAEIVSL FSDVPDSTSA ALLDTALVNS GILTIDVASV SSTLAGHLPA NNNNSVGQAV
DPPSLMATSD PPQSLDTSLF FGTAATGFQQ SSLNMDEVSS VSVGPLGSLD SLAMKNSSPE
PQALTPSSKL TVDTDALTPS STLCENSVSE LLTPTKAEWN VHPDSDFFGQ EGETQFGFPN
AAGNHGSQKE TDLITVTGSS FLV
//
