ID Y2456_MYCTU Reviewed; 418 AA.
AC P9WJX1; L0TB98; O53183; Q7D741;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Uncharacterized MFS-type transporter Rv2456c;
GN OrderedLocusNames=Rv2456c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011445;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AL123456; CCP45249.1; -; Genomic_DNA.
DR PIR; G70864; G70864.
DR RefSeq; NP_216972.1; NC_000962.3.
DR RefSeq; WP_003412631.1; NZ_NVQJ01000024.1.
DR AlphaFoldDB; P9WJX1; -.
DR SMR; P9WJX1; -.
DR STRING; 83332.Rv2456c; -.
DR PaxDb; 83332-Rv2456c; -.
DR DNASU; 887340; -.
DR GeneID; 887340; -.
DR KEGG; mtu:Rv2456c; -.
DR TubercuList; Rv2456c; -.
DR eggNOG; COG2814; Bacteria.
DR InParanoid; P9WJX1; -.
DR OrthoDB; 9812574at2; -.
DR PhylomeDB; P9WJX1; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23539:SF1; MFS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23539; MFS TRANSPORTER; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 2.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..418
FT /note="Uncharacterized MFS-type transporter Rv2456c"
FT /id="PRO_0000390684"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 418 AA; 43133 MW; A82674452423CB76 CRC64;
MSGTVVAVPP RVARALDLLN FSLADVRDGL GPYLSIYLLL IHDWDQASIG FVMAVGGIAA
IVAQTPIGAL VDRTTAKRAL VVAGAVLVTA AAVAMPLFAG LYSISVLQAV TGIASSVFAP
ALAAITLGAV GPQFFARRIG RNEAFNHAGN ASAAGATGAL AYFFGPVVVF WVLAGMALIS
VLATLRIPPD AVDHDLARGM DHAPGEPHPQ PSRFTVLAHN RELVIFGAAV VAFHFANAAM
LPLVGELLAL HNRDEGTALM SSCIVAAQVV MVPVAYVVGT RADAWGRKPI FLVGFAVLTA
RGFLYTLSDN SYWLVGVQLL DGIGAGIFGA LFPLVVQDVT HGTGHFNISL GAVTTATGIG
AALSNLVAGW IVVVAGYDAA FMSLGALAGA GFLLYLVAMP ETVDSDVRVR SRPTLGGK
//
