ID Y485_MYCTO Reviewed; 438 AA.
AC P9WKV0; L0T5I1; P64705; Q11151;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Transcriptional regulator MT0503 {ECO:0000250|UniProtKB:P9WKV1};
GN OrderedLocusNames=MT0503;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Positively regulates the expression of PE13 and PPE18.
CC {ECO:0000250|UniProtKB:P9WKV1}.
CC -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR EMBL; AE000516; AAK44726.1; -; Genomic_DNA.
DR PIR; H70743; H70743.
DR RefSeq; WP_003402361.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WKV0; -.
DR SMR; P9WKV0; -.
DR KEGG; mtc:MT0503; -.
DR PATRIC; fig|83331.31.peg.533; -.
DR HOGENOM; CLU_036604_13_4_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000600; ROK.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR18964:SF177; N-ACETYLMANNOSAMINE KINASE; 1.
DR PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR Pfam; PF00480; ROK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..438
FT /note="Transcriptional regulator MT0503"
FT /id="PRO_0000427590"
FT DNA_BIND 52..73
FT /note="H-T-H motif"
FT /evidence="ECO:0000250|UniProtKB:P9WKV1"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 46099 MW; D75B8F6777DE1E6F CRC64;
MYSTNRTSQS LSRKPGRKHQ LRSHRYVMPP SLHLSDSAAA SVFRAVRLRG PVGRDVIAGS
TSLSIATVNR QVIALLEAGL LRERADLAVS GAIGRPRVPV EVNHEPFVTL GIHIGARTTS
IVATDLFGRT LDTVETPTPR NAAGAALTSL ADSADRYLQR WRRRRALWVG VTLGGAVDSA
TGHVDHPRLG WRQAPVGPVL ADALGLPVSV ASHVDAMAGA ELMLGMRRFA PSSSTSLYVY
ARETVGYALM IGGRVHCPAS GPGTIAPLPV HSEMLGGTGQ LESTVSDEAV LAAARRLRII
PGIASRTRTG GSATAITDLL RVARAGNQQA KELLAERARV LGGAVALLRD LLNPDEVVVG
GQAFTEYPEA MEQVEAAFTA GSVLAPRDIR VTVFGNRVQE AGAGIVSLSG LYADPLGALR
RSGALDARLQ DTAPEALA
//
