ID PAX9_MACMU Reviewed; 341 AA.
AC Q2VL61;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Paired box protein Pax-9;
GN Name=PAX9;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate 19935-305;
RX PubMed=16326750; DOI=10.1093/molbev/msj072;
RA Perry G.H., Verrelli B.C., Stone A.C.;
RT "Molecular evolution of the primate developmental genes MSX1 and PAX9.";
RL Mol. Biol. Evol. 23:644-654(2006).
CC -!- FUNCTION: Transcription factor required for normal development of
CC thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal
CC elements of skull and larynx as well as distal limbs. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with KDM5B. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; DQ067510; AAZ39855.1; -; Genomic_DNA.
DR EMBL; DQ067508; AAZ39855.1; JOINED; Genomic_DNA.
DR EMBL; DQ067509; AAZ39855.1; JOINED; Genomic_DNA.
DR AlphaFoldDB; Q2VL61; -.
DR SMR; Q2VL61; -.
DR STRING; 9544.ENSMMUP00000012620; -.
DR PaxDb; 9544-ENSMMUP00000012620; -.
DR eggNOG; KOG3517; Eukaryota.
DR HOGENOM; CLU_019281_3_0_1; -.
DR InParanoid; Q2VL61; -.
DR TreeFam; TF315397; -.
DR Proteomes; UP000006718; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR PANTHER; PTHR45636:SF13; PAIRED BOX PROTEIN PAX-9; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Paired box;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..341
FT /note="Paired box protein Pax-9"
FT /id="PRO_0000050207"
FT DNA_BIND 4..130
FT /note="Paired"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 7..63
FT /note="PAI subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 82..130
FT /note="RED subdomain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00381"
FT REGION 168..189
FT /note="Interaction with KDM5B"
FT /evidence="ECO:0000250"
SQ SEQUENCE 341 AA; 36408 MW; AD549C8F48C81B1A CRC64;
MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH GCVSKILARY
NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW EIRDRLLADG VCDKYNVPSV
SSISRILRNK IGNLAQQGHY DSYKQHQPTP QPALPYNHIY SYPSPITAAA AKVPTPPGVP
AIPGSVAMPR TWPSSHSVTD ILGIRSITDQ VSDSSPYHSP KVEEWSSLGR NNFPATAPHA
VNGLEKGVLE QEAKYGQAPN GLPAVGSFVS ASSMAPYPTP AQVSPYMTYS AAPSGYVAGH
GWQHAGSTPL SPHNCDIPAS LAFKGMQAAR EGSHSVTASA L
//
