ID PCDGG_HUMAN Reviewed; 923 AA.
AC Q9UN71; O15099; Q2M267; Q9UN64;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 24-JAN-2024, entry version 167.
DE RecName: Full=Protocadherin gamma-B4;
DE Short=PCDH-gamma-B4;
DE AltName: Full=Cadherin-20;
DE AltName: Full=Fibroblast cadherin-2;
DE Flags: Precursor;
GN Name=PCDHGB4; Synonyms=CDH20, FIB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=10380929; DOI=10.1016/s0092-8674(00)80789-8;
RA Wu Q., Maniatis T.;
RT "A striking organization of a large family of human neural cadherin-like
RT cell adhesion genes.";
RL Cell 97:779-790(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 94-234.
RX PubMed=9199196; DOI=10.1006/bbrc.1997.6707;
RA Matsuyoshi N., Imamura S.;
RT "Multiple cadherins are expressed in human fibroblasts.";
RL Biochem. Biophys. Res. Commun. 235:355-358(1997).
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9UN71-1; Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=Q9UN71-2; Sequence=VSP_008690, VSP_008691;
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DR EMBL; AF152333; AAD43727.1; -; mRNA.
DR EMBL; AF152520; AAD43780.1; -; mRNA.
DR EMBL; CH471062; EAW61927.1; -; Genomic_DNA.
DR EMBL; BC112088; AAI12089.1; -; mRNA.
DR EMBL; BC113607; AAI13608.1; -; mRNA.
DR EMBL; AB000896; BAA21134.1; -; mRNA.
DR CCDS; CCDS54928.1; -. [Q9UN71-1]
DR CCDS; CCDS75337.1; -. [Q9UN71-2]
DR PIR; PC4298; PC4298.
DR RefSeq; NP_003727.1; NM_003736.2. [Q9UN71-1]
DR RefSeq; NP_115269.1; NM_032098.1. [Q9UN71-2]
DR AlphaFoldDB; Q9UN71; -.
DR SMR; Q9UN71; -.
DR BioGRID; 114193; 60.
DR IntAct; Q9UN71; 55.
DR STRING; 9606.ENSP00000428288; -.
DR GlyConnect; 1688; 4 N-Linked glycans (1 site).
DR GlyCosmos; Q9UN71; 2 sites, 3 glycans.
DR GlyGen; Q9UN71; 2 sites, 3 N-linked glycans (1 site).
DR iPTMnet; Q9UN71; -.
DR PhosphoSitePlus; Q9UN71; -.
DR SwissPalm; Q9UN71; -.
DR BioMuta; PCDHGB4; -.
DR DMDM; 37999814; -.
DR jPOST; Q9UN71; -.
DR MassIVE; Q9UN71; -.
DR MaxQB; Q9UN71; -.
DR PaxDb; 9606-ENSP00000428288; -.
DR PeptideAtlas; Q9UN71; -.
DR ProteomicsDB; 85257; -. [Q9UN71-1]
DR ProteomicsDB; 85258; -. [Q9UN71-2]
DR Antibodypedia; 56131; 110 antibodies from 15 providers.
DR DNASU; 8641; -.
DR Ensembl; ENST00000519479.2; ENSP00000428288.1; ENSG00000253953.3. [Q9UN71-1]
DR Ensembl; ENST00000615384.1; ENSP00000484560.1; ENSG00000253953.3. [Q9UN71-2]
DR GeneID; 8641; -.
DR KEGG; hsa:8641; -.
DR MANE-Select; ENST00000519479.2; ENSP00000428288.1; NM_003736.4; NP_003727.1.
DR UCSC; uc003lkc.3; human. [Q9UN71-1]
DR AGR; HGNC:8711; -.
DR CTD; 8641; -.
DR GeneCards; PCDHGB4; -.
DR HGNC; HGNC:8711; PCDHGB4.
DR HPA; ENSG00000253953; Low tissue specificity.
DR MalaCards; PCDHGB4; -.
DR MIM; 603058; gene.
DR MIM; 604968; gene.
DR neXtProt; NX_Q9UN71; -.
DR OpenTargets; ENSG00000253953; -.
DR PharmGKB; PA33059; -.
DR VEuPathDB; HostDB:ENSG00000253953; -.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000156683; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; Q9UN71; -.
DR OMA; TALDCGD; -.
DR OrthoDB; 5402790at2759; -.
DR PhylomeDB; Q9UN71; -.
DR TreeFam; TF332299; -.
DR PathwayCommons; Q9UN71; -.
DR SignaLink; Q9UN71; -.
DR SIGNOR; Q9UN71; -.
DR BioGRID-ORCS; 8641; 8 hits in 1096 CRISPR screens.
DR GenomeRNAi; 8641; -.
DR Pharos; Q9UN71; Tbio.
DR PRO; PR:Q9UN71; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9UN71; Protein.
DR Bgee; ENSG00000253953; Expressed in stromal cell of endometrium and 106 other cell types or tissues.
DR Genevisible; Q9UN71; HS.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; NAS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF117; PROTOCADHERIN GAMMA-B4; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 5.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Cell adhesion; Cell membrane; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..923
FT /note="Protocadherin gamma-B4"
FT /id="PRO_0000003977"
FT TOPO_DOM 31..689
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 711..923
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..133
FT /note="Cadherin 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 134..242
FT /note="Cadherin 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 243..345
FT /note="Cadherin 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 346..450
FT /note="Cadherin 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 451..560
FT /note="Cadherin 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT DOMAIN 568..673
FT /note="Cadherin 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00043"
FT REGION 797..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 417
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 543
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 800..803
FT /note="QAPP -> VSFL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_008690"
FT VAR_SEQ 804..923
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10380929,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_008691"
SQ SEQUENCE 923 AA; 99927 MW; 649A8F509CE1B31A CRC64;
MGSGAGELGR AERLPVLFLF LLSLFCPALC EQIRYRIPEE MPKGSVVGNL ATDLGFSVQE
LPTRKLRVSS EKPYFTVSAE SGELLVSSRL DREEICGKKP ACALEFEAVA ENPLNFYHVN
VEIEDINDHT PKFTQNSFEL QISESAQPGT RFILGSAHDA DIGSNTLQNY QLSPSDHFSL
INKEKSDGSK YPEMVLKTPL DREKQKSYHL TLTALDFGAP PLSSTAQIHV LVTDANDNAP
VFSQDVYRVS LSENVYPGTT VLQVTATDQD EGVNAEITFS FSEASQITQF DLNSNTGEIT
VLNTLDFEEV KEYSIVLEAR DGGGMIAQCT VEVEVIDEND NAPEVIFQSL PNLIMEDAEL
GTHIALLKVR DKDSRHNGEV TCKLEGDVPF KILTSSRNTY KLVTDAVLDR EQNPEYNITV
TATDRGKPPL SSSSSITLHI GDVNDNAPVF SQSSYIVHVA ENNPPGASIS QVRASDPDLG
PNGQVSYCIM ASDLEQRELS SYVSISAESG VVFAQRAFDH EQLRAFELTL QARDQGSPAL
SANVSLRVLV DDRNDNAPRV LYPALGPDGS ALFDMVPHAA EPGYLVTKVV AVDADSGHNA
WLSYHVLQAS EPGLFSLGLR TGEVRTARAL GDRDAVRQRL LVAVRDGGQP PLSATATLHL
VFADSLQEVL PDITDRPDPS DLQAELQFYL VVALALISVL FLVAMILAIA LRLRRSSSPA
SWSCFQPGLC VKSESVVPPN YSEGTLPYSY NLCVAHTGKT EFNFLKCSEQ LSSGQDILCG
DSSGALFPLC NSSELTSHQQ APPNTDWRFS QAQRPGTSGS QNGDDTGTWP NNQFDTEMLQ
AMILASASEA ADGSSTLGGG AGTMGLSARY GPQFTLQHVP DYRQNVYIPG SNATLTNAAG
KRDGKAPAGG NGNKKKSGKK EKK
//
