ID PCHA_PSEAE Reviewed; 476 AA.
AC Q51508;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE RecName: Full=Salicylate biosynthesis isochorismate synthase;
DE EC=5.4.4.2;
DE AltName: Full=Isochorismate mutase;
GN Name=pchA; OrderedLocusNames=PA4231;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND CHARACTERIZATION.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=7500944; DOI=10.1007/bf00290369;
RA Serino L., Reimmann C., Baur H., Beyeler M., Visca P., Haas D.;
RT "Structural genes for salicylate biosynthesis from chorismate in
RT Pseudomonas aeruginosa.";
RL Mol. Gen. Genet. 249:217-228(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Involved in the conversion of chorismate to salicylate.
CC {ECO:0000269|PubMed:7500944}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC -!- PATHWAY: Siderophore biosynthesis; salicylate biosynthesis.
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000305}.
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DR EMBL; X82644; CAA57969.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG07619.1; -; Genomic_DNA.
DR PIR; S60203; S58229.
DR RefSeq; NP_252921.1; NC_002516.2.
DR RefSeq; WP_003114686.1; NZ_QZGE01000028.1.
DR AlphaFoldDB; Q51508; -.
DR SMR; Q51508; -.
DR STRING; 208964.PA4231; -.
DR PaxDb; 208964-PA4231; -.
DR GeneID; 881821; -.
DR KEGG; pae:PA4231; -.
DR PATRIC; fig|208964.12.peg.4432; -.
DR PseudoCAP; PA4231; -.
DR HOGENOM; CLU_006493_8_4_6; -.
DR InParanoid; Q51508; -.
DR OrthoDB; 9806579at2; -.
DR PhylomeDB; Q51508; -.
DR BioCyc; MetaCyc:MONOMER-15306; -.
DR BioCyc; PAER208964:G1FZ6-4304-MONOMER; -.
DR BRENDA; 5.4.4.2; 5087.
DR UniPathway; UPA00025; -.
DR PHI-base; PHI:5057; -.
DR PHI-base; PHI:6988; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0008909; F:isochorismate synthase activity; IDA:PseudoCAP.
DR GO; GO:0042864; P:pyochelin biosynthetic process; IDA:CACAO.
DR GO; GO:0009697; P:salicylic acid biosynthetic process; IDA:PseudoCAP.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF1; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 1: Evidence at protein level;
KW Isomerase; Reference proteome.
FT CHAIN 1..476
FT /note="Salicylate biosynthesis isochorismate synthase"
FT /id="PRO_0000154151"
FT REGION 181..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 476 AA; 52071 MW; D0F6AFD9CDCF9CF5 CRC64;
MSRLAPLSQC LHALRGTFER AIGQAQALDR PVLVAASFEI DPLDPLQVFG AWDDRQTPCL
YWEQPELAFF AWGCALELQG HGEQRFARIE ENWQLLCADA VVEGPLAPRL CGGFRFDPRG
PREEHWQAFA DASLMLAGIT VLREGERYRV LCQHLAKPGE DALALAAYHC SALLRLRQPA
RRRPSGPTAG AQGDASAQER RQWEAKVSDA VSSVRQGRFG KVVLARTQAR PLGDIEPWQV
IEHLRLQHAD AQLFACRRGN ACFLGASPER LVRIRAGEAL THALAGTIAR GGDAQEDARL
GQALLDSAKD RHEHQLVVEA IRTALEPFSE VLEIPDAPGL KRLARVQHLN TPIRARLADA
GGILRLLQAL HPTPAVGGYP RSAALDYIRQ HEGMDRGWYA APLGWLDGEG NGDFLVALRS
ALLTPGRGYL FAGCGLVGDS EPAHEYRETC LKLSAMREAL SAIGGLDEVP LQRGVA
//
