ID PESC_BRUMA Reviewed; 535 AA.
AC A8QHQ0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN ORFNames=Bm1_57380;
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDP28218.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; DS239957; EDP28218.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_001902934.1; XM_001902899.1.
DR AlphaFoldDB; A8QHQ0; -.
DR SMR; A8QHQ0; -.
DR STRING; 6279.A8QHQ0; -.
DR WormBase; Bm13949; BM24668; WBGene00234210; Bma-lpd-7.
DR InParanoid; A8QHQ0; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR CDD; cd17709; BRCT_pescadillo_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..535
FT /note="Pescadillo homolog"
FT /id="PRO_0000370464"
FT DOMAIN 314..406
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
SQ SEQUENCE 535 AA; 62896 MW; 26AA0A0694A4D98B CRC64;
MRHFTYHSDV VVWQYIFESG AATNYITRGR ALKKLQLSLK DFRRLCILKG VYPHEPLHKK
KVNKGSTENR VYYYAKDINF LASEPIIRKF REYKIFLRKL TTAKAKRDEE RIKTLYENRP
EYQLDHIVKE RYPTFESALR DLDDALCLLF AFAVLPHTKI ITSSLVASSR RLTAEFNHYI
IESNSLNKVF VSIKGIYYEA EVMGERVTWI VGHDRGMGHV SEVDFSVMAT FAEFYVTMLE
FVNFRLYQSV GLFYPPKLAF KSDKLEDDDQ AEEGRVYSLA CPLSKFENYE EQIDASIGDE
VDNVLNEKLC DVEKRKQLFA NYRFWLNREV PKDVLAIIIR SCGGLVSWEN CPAAQYYEND
AQITHQIVDR PLLDSHKNIS RCYVQPQWVF DSFNRRSCLS IKKYLPGAIL PPHLSPFSSD
YDTYEEQLNQ LRLLSKASAN VTNRMETEAE NKVQERKKIQ KEKEVPIINV NKGRMHKENL
QKKLNEKGHE LKLREMLIPK KRRRVYSKIK RGIKRRVHEE KKLNEKRLKM LKAAD
//
