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Database: UniProt
Entry: PHEA_LACLA
LinkDB: PHEA_LACLA
Original site: PHEA_LACLA 
ID   PHEA_LACLA              Reviewed;         279 AA.
AC   Q9CEU2;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   18-SEP-2019, entry version 97.
DE   RecName: Full=Prephenate dehydratase;
DE            Short=PDT;
DE            EC=4.2.1.51;
GN   Name=pheA; OrderedLocusNames=LL1742; ORFNames=L0055;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus
OS   lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA   Weissenbach J., Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
DR   EMBL; AE005176; AAK05840.1; -; Genomic_DNA.
DR   PIR; F86842; F86842.
DR   RefSeq; NP_267898.1; NC_002662.1.
DR   RefSeq; WP_010906115.1; NC_002662.1.
DR   SMR; Q9CEU2; -.
DR   STRING; 272623.L0055; -.
DR   PaxDb; Q9CEU2; -.
DR   EnsemblBacteria; AAK05840; AAK05840; L0055.
DR   GeneID; 1115405; -.
DR   KEGG; lla:L0055; -.
DR   PATRIC; fig|272623.7.peg.1868; -.
DR   eggNOG; ENOG4105CQC; Bacteria.
DR   eggNOG; COG0077; LUCA.
DR   KO; K04518; -.
DR   OMA; REVMSAC; -.
DR   BioCyc; LLAC272623:L0055-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF00800; PDT; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Phenylalanine biosynthesis;
KW   Reference proteome.
FT   CHAIN         1    279       Prephenate dehydratase.
FT                                /FTId=PRO_0000119178.
FT   DOMAIN        2    178       Prephenate dehydratase.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00517}.
FT   DOMAIN      194    270       ACT. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01007}.
FT   SITE        171    171       Essential for activity. {ECO:0000250}.
SQ   SEQUENCE   279 AA;  30966 MW;  0F2A839340C69AFC CRC64;
     MKIAYLGPRG SFCSVVAETA FVSEELFAYD SILDVIEAYD EGKCDFALVP IENSTEGTVN
     MSIDKIFHDS KATVVAEFVL PISQNLLALS KEGKIEHIYS HPQALAQTRN YLREHYPQAK
     VEITDSTSAA AEFVKNHPDL PIAAVANSYA AKMYDLEIVA KNIQDLAGNS TRFWLLGKEK
     KSFDLLKTGE KVSLALTLPD NLPGALHKAI SVFAWRDIDM TKIESRPLRT RLGQYFFNID
     LVNNEKNNLK IPYALEELSG LGVKVRLLGN YAVYSLGEG
//
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