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Database: UniProt
Entry: PHEA_MYCLE
LinkDB: PHEA_MYCLE
Original site: PHEA_MYCLE 
ID   PHEA_MYCLE              Reviewed;         322 AA.
AC   Q9CDC4;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   08-MAY-2019, entry version 90.
DE   RecName: Full=Prephenate dehydratase;
DE            Short=PDT;
DE            EC=4.2.1.51;
GN   Name=pheA; OrderedLocusNames=ML0078;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
DR   EMBL; AL583917; CAC29586.1; -; Genomic_DNA.
DR   PIR; F86918; F86918.
DR   RefSeq; NP_301183.1; NC_002677.1.
DR   RefSeq; WP_010907508.1; NC_002677.1.
DR   SMR; Q9CDC4; -.
DR   STRING; 272631.ML0078; -.
DR   EnsemblBacteria; CAC29586; CAC29586; CAC29586.
DR   GeneID; 910395; -.
DR   KEGG; mle:ML0078; -.
DR   PATRIC; fig|272631.5.peg.122; -.
DR   Leproma; ML0078; -.
DR   eggNOG; ENOG4105CQC; Bacteria.
DR   eggNOG; COG0077; LUCA.
DR   HOGENOM; HOG000018970; -.
DR   KO; K04518; -.
DR   OMA; REVMSAC; -.
DR   BioCyc; MLEP272631:G1GT5-87-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Phenylalanine biosynthesis;
KW   Reference proteome.
FT   CHAIN         1    322       Prephenate dehydratase.
FT                                /FTId=PRO_0000382035.
FT   DOMAIN        5    191       Prephenate dehydratase.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00517}.
FT   DOMAIN      205    282       ACT. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01007}.
FT   SITE        184    184       Essential for activity. {ECO:0000250}.
SQ   SEQUENCE   322 AA;  33549 MW;  85C7FBB5866B8524 CRC64;
     MSVARIAYLG PEGTFTEAAL LRMTAAGLVP DTGPDGLRRW PTESTPAALD AVRGGAADYA
     CVPIENSIDG SVAPTLDNLA IGSPLQVFAE TTLDVEFNIV VKPGITAADI RTLAAFPVAA
     AQVRQWLAAH LAGAELRPAY SNADAARQVA YGQVDAAVTS PLAATRWGLI ALAAGIVDEP
     NARTRFVLVG MPGPPPARTG TDRTSAVLRI DNAPGMLVAA LAEFGIRGID LTRIESRPTR
     TELGTYLFFV DCVGHIDDGV VAEALKALHR RCADVCYLGS WPAGLATGPT VSPPPPDEAS
     RWLARLRAGK PDQASEPGGG KL
//
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