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Database: UniProt
Entry: PHOU2_THEMA
LinkDB: PHOU2_THEMA
Original site: PHOU2_THEMA 
ID   PHOU2_THEMA             Reviewed;         235 AA.
AC   Q9X256;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   27-MAR-2024, entry version 136.
DE   RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog 2;
DE            Short=Pst system accessory protein PhoU homolog 2;
DE   AltName: Full=Phosphate uptake regulator PhoU homolog 2;
GN   Name=phoU2; OrderedLocusNames=TM_1734;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC   Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH IRON IONS AND NICKEL
RP   ION.
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=15716271; DOI=10.1074/jbc.m414117200;
RA   Liu J., Lou Y., Yokota H., Adams P.D., Kim R., Kim S.H.;
RT   "Crystal structure of a PhoU protein homologue: a new class of
RT   metalloprotein containing multinuclear iron clusters.";
RL   J. Biol. Chem. 280:15960-15966(2005).
CC   -!- FUNCTION: Plays a role in the regulation of phosphate uptake.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000305}.
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DR   EMBL; AE000512; AAD36799.1; -; Genomic_DNA.
DR   PIR; E72217; E72217.
DR   RefSeq; NP_229532.1; NC_000853.1.
DR   RefSeq; WP_004082252.1; NZ_CP011107.1.
DR   PDB; 1SUM; X-ray; 2.00 A; B=1-235.
DR   PDBsum; 1SUM; -.
DR   AlphaFoldDB; Q9X256; -.
DR   SMR; Q9X256; -.
DR   STRING; 243274.TM_1734; -.
DR   PaxDb; 243274-THEMA_05565; -.
DR   EnsemblBacteria; AAD36799; AAD36799; TM_1734.
DR   KEGG; tma:TM1734; -.
DR   eggNOG; COG0704; Bacteria.
DR   InParanoid; Q9X256; -.
DR   OrthoDB; 45908at2; -.
DR   EvolutionaryTrace; Q9X256; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030643; P:intracellular phosphate ion homeostasis; IEA:InterPro.
DR   GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR   GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR028366; P_transport_PhoU.
DR   InterPro; IPR038078; PhoU-like_sf.
DR   InterPro; IPR026022; PhoU_dom.
DR   NCBIfam; TIGR02135; phoU_full; 1.
DR   PANTHER; PTHR42930; PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU; 1.
DR   PANTHER; PTHR42930:SF3; PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU; 1.
DR   Pfam; PF01895; PhoU; 2.
DR   PIRSF; PIRSF003107; PhoU; 1.
DR   SUPFAM; SSF109755; PhoU-like; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Phosphate transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..235
FT                   /note="Phosphate-specific transport system accessory
FT                   protein PhoU homolog 2"
FT                   /id="PRO_0000155183"
FT   HELIX           5..36
FT                   /evidence="ECO:0007829|PDB:1SUM"
FT   HELIX           39..70
FT                   /evidence="ECO:0007829|PDB:1SUM"
FT   HELIX           75..107
FT                   /evidence="ECO:0007829|PDB:1SUM"
FT   HELIX           118..138
FT                   /evidence="ECO:0007829|PDB:1SUM"
FT   HELIX           142..145
FT                   /evidence="ECO:0007829|PDB:1SUM"
FT   HELIX           147..172
FT                   /evidence="ECO:0007829|PDB:1SUM"
FT   HELIX           174..176
FT                   /evidence="ECO:0007829|PDB:1SUM"
FT   HELIX           177..209
FT                   /evidence="ECO:0007829|PDB:1SUM"
FT   STRAND          213..216
FT                   /evidence="ECO:0007829|PDB:1SUM"
FT   STRAND          219..222
FT                   /evidence="ECO:0007829|PDB:1SUM"
SQ   SEQUENCE   235 AA;  26821 MW;  48558C71B710D831 CRC64;
     MNRLLNEKVE EFKKGVLKAG WFIEKMFRNS ISSLVERNES LAREVIADEE VVDQMEVEIQ
     EKAMEVLGLF SPIGKPLLTV TAGIRVAELI ENIADKCHDI AKNVLELMEE PPLKPLEDIP
     AMANQTSEML KFALRMFADV NVEKSFEVCR MDSKVDDLYE KVREELLLYM MESPKYVKRA
     LLLLEIAGNI EIIADYATNI VEVSVYMVQG EAYKCYHDEL LLFKKSGGVL FESSD
//
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