ID PHS_VIBCH Reviewed; 109 AA.
AC Q9KLB9;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=Putative pterin-4-alpha-carbinolamine dehydratase;
DE Short=PHS;
DE EC=4.2.1.96;
DE AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase;
DE AltName: Full=Pterin carbinolamine dehydratase;
DE Short=PCD;
GN OrderedLocusNames=VC_A0827;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000305}.
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DR EMBL; AE003853; AAF96725.1; -; Genomic_DNA.
DR PIR; C82413; C82413.
DR RefSeq; NP_233213.1; NC_002506.1.
DR RefSeq; WP_000883446.1; NZ_LT906615.1.
DR AlphaFoldDB; Q9KLB9; -.
DR SMR; Q9KLB9; -.
DR STRING; 243277.VC_A0827; -.
DR DNASU; 2612720; -.
DR EnsemblBacteria; AAF96725; AAF96725; VC_A0827.
DR KEGG; vch:VC_A0827; -.
DR PATRIC; fig|243277.26.peg.3446; -.
DR eggNOG; COG2154; Bacteria.
DR HOGENOM; CLU_081974_2_2_6; -.
DR Proteomes; UP000000584; Chromosome 2.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR CDD; cd00913; PCD_DCoH_subfamily_a; 1.
DR Gene3D; 3.30.1360.20; Transcriptional coactivator/pterin dehydratase; 1.
DR HAMAP; MF_00434; Pterin_4_alpha; 1.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR PANTHER; PTHR42805; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR42805:SF1; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE-RELATED; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR SUPFAM; SSF55248; PCD-like; 1.
PE 3: Inferred from homology;
KW Lyase; Reference proteome.
FT CHAIN 1..109
FT /note="Putative pterin-4-alpha-carbinolamine dehydratase"
FT /id="PRO_0000063101"
SQ SEQUENCE 109 AA; 12420 MW; 4C1369EF845617B2 CRC64;
MLDELRCEAC SAGAIGLTSE EQQQLLSELD GWALIHRDGI AQLEKRYRFK NFKQAWAFSN
QIAELAEQEF HNPAILLEWG NVTVTWWSHS IKGLHKNDFI CAAKCDALT
//
