ID PIGC_RAT Reviewed; 297 AA.
AC Q5PQQ4;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 24-JAN-2024, entry version 121.
DE RecName: Full=Phosphatidylinositol N-acetylglucosaminyltransferase subunit C {ECO:0000305};
DE AltName: Full=Phosphatidylinositol-glycan biosynthesis class C protein;
DE Short=PIG-C;
GN Name=Pigc {ECO:0000312|RGD:1311337};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Part of the glycosylphosphatidylinositol-N-
CC acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the
CC transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
CC phosphatidylinositol and participates in the first step of GPI
CC biosynthesis. {ECO:0000250|UniProtKB:Q92535}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000250|UniProtKB:Q92535}.
CC -!- SUBUNIT: Component of the glycosylphosphatidylinositol-N-
CC acetylglucosaminyltransferase (GPI-GnT) complex composed at least by
CC PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGQ.
CC Interacts with the heterodimer PIGA:PIGH.
CC {ECO:0000250|UniProtKB:Q92535}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q92535}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q92535}.
CC -!- SIMILARITY: Belongs to the PIGC family. {ECO:0000305}.
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DR EMBL; BC087080; AAH87080.1; -; mRNA.
DR RefSeq; NP_001012207.1; NM_001012207.1.
DR RefSeq; XP_006250244.1; XM_006250182.2.
DR RefSeq; XP_006250245.1; XM_006250183.2.
DR RefSeq; XP_008767887.1; XM_008769665.2.
DR AlphaFoldDB; Q5PQQ4; -.
DR STRING; 10116.ENSRNOP00000035922; -.
DR PhosphoSitePlus; Q5PQQ4; -.
DR PaxDb; 10116-ENSRNOP00000035922; -.
DR Ensembl; ENSRNOT00000035558.5; ENSRNOP00000035922.3; ENSRNOG00000026497.5.
DR Ensembl; ENSRNOT00000076417.2; ENSRNOP00000068091.2; ENSRNOG00000026497.5.
DR Ensembl; ENSRNOT00000077069.2; ENSRNOP00000068000.2; ENSRNOG00000026497.5.
DR Ensembl; ENSRNOT00000105154.1; ENSRNOP00000094482.1; ENSRNOG00000026497.5.
DR Ensembl; ENSRNOT00055030118; ENSRNOP00055024194; ENSRNOG00055017804.
DR Ensembl; ENSRNOT00055030120; ENSRNOP00055024196; ENSRNOG00055017804.
DR Ensembl; ENSRNOT00055030122; ENSRNOP00055024198; ENSRNOG00055017804.
DR Ensembl; ENSRNOT00055030123; ENSRNOP00055024199; ENSRNOG00055017804.
DR Ensembl; ENSRNOT00060014463; ENSRNOP00060011125; ENSRNOG00060008663.
DR Ensembl; ENSRNOT00060014469; ENSRNOP00060011132; ENSRNOG00060008663.
DR Ensembl; ENSRNOT00060014472; ENSRNOP00060011135; ENSRNOG00060008663.
DR Ensembl; ENSRNOT00060014476; ENSRNOP00060011138; ENSRNOG00060008663.
DR Ensembl; ENSRNOT00065033741; ENSRNOP00065027016; ENSRNOG00065020014.
DR Ensembl; ENSRNOT00065033753; ENSRNOP00065027025; ENSRNOG00065020014.
DR Ensembl; ENSRNOT00065033761; ENSRNOP00065027029; ENSRNOG00065020014.
DR Ensembl; ENSRNOT00065033766; ENSRNOP00065027030; ENSRNOG00065020014.
DR GeneID; 364032; -.
DR KEGG; rno:364032; -.
DR UCSC; RGD:1311337; rat.
DR AGR; RGD:1311337; -.
DR CTD; 5279; -.
DR RGD; 1311337; Pigc.
DR eggNOG; KOG3059; Eukaryota.
DR GeneTree; ENSGT00390000005496; -.
DR HOGENOM; CLU_024002_0_0_1; -.
DR InParanoid; Q5PQQ4; -.
DR OMA; STSYHAF; -.
DR OrthoDB; 205848at2759; -.
DR PhylomeDB; Q5PQQ4; -.
DR TreeFam; TF314325; -.
DR Reactome; R-RNO-162710; Synthesis of glycosylphosphatidylinositol (GPI).
DR UniPathway; UPA00196; -.
DR PRO; PR:Q5PQQ4; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000026497; Expressed in quadriceps femoris and 19 other cell types or tissues.
DR ExpressionAtlas; Q5PQQ4; baseline and differential.
DR Genevisible; Q5PQQ4; RN.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:RGD.
DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; ISS:UniProtKB.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR InterPro; IPR009450; Plno_GlcNAc_GPI2.
DR PANTHER; PTHR12982; PHOSPHATIDYLINOSITOL GLYCAN, CLASS C; 1.
DR PANTHER; PTHR12982:SF0; PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C; 1.
DR Pfam; PF06432; GPI2; 1.
DR PIRSF; PIRSF016104; GPI2; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; GPI-anchor biosynthesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..297
FT /note="Phosphatidylinositol N-acetylglucosaminyltransferase
FT subunit C"
FT /id="PRO_0000058433"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 297 AA; 33666 MW; FE914EE878ED8597 CRC64;
MCAQHVADTS EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA VVFESSVVIQ
QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF DLIDGGDGRK KSGRTRWADL
KSTLVFITFT YGFSPVLKTL TESVSTDTIY AMSVFMLLGH LIFFDYGANA AIVSSTLSLN
MAIFASVCLA SRLPRSLHAF IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF
GGLLSISGVG AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS
//
