ID PLHD1_CAEEL Reviewed; 570 AA.
AC O45420; B7WNA6; B7WNA7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 2.
DT 27-MAR-2024, entry version 122.
DE RecName: Full=Pleckstrin homology domain-containing family D member 1;
DE Short=PH domain-containing family D member 1;
GN ORFNames=F31D4.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O45420-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O45420-2; Sequence=VSP_038217;
CC -!- SIMILARITY: Belongs to the PLEKHD1 family. {ECO:0000305}.
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DR EMBL; Z92832; CAV31773.1; -; Genomic_DNA.
DR EMBL; Z92832; CAV31774.1; -; Genomic_DNA.
DR PIR; T21596; T21596.
DR RefSeq; NP_001256959.1; NM_001270030.1. [O45420-1]
DR RefSeq; NP_001256960.1; NM_001270031.1. [O45420-2]
DR AlphaFoldDB; O45420; -.
DR SMR; O45420; -.
DR BioGRID; 45329; 1.
DR STRING; 6239.F31D4.5a.1; -.
DR EPD; O45420; -.
DR PaxDb; 6239-F31D4-5a; -.
DR PeptideAtlas; O45420; -.
DR EnsemblMetazoa; F31D4.5a.1; F31D4.5a.1; WBGene00009292. [O45420-1]
DR EnsemblMetazoa; F31D4.5b.1; F31D4.5b.1; WBGene00009292. [O45420-2]
DR GeneID; 180373; -.
DR KEGG; cel:CELE_F31D4.5; -.
DR UCSC; F31D4.5; c. elegans. [O45420-1]
DR AGR; WB:WBGene00009292; -.
DR WormBase; F31D4.5a; CE43424; WBGene00009292; -. [O45420-1]
DR WormBase; F31D4.5b; CE43425; WBGene00009292; -. [O45420-2]
DR eggNOG; ENOG502QTF5; Eukaryota.
DR GeneTree; ENSGT00950000183017; -.
DR HOGENOM; CLU_035364_0_0_1; -.
DR InParanoid; O45420; -.
DR OMA; KTNCILA; -.
DR OrthoDB; 4272402at2759; -.
DR PhylomeDB; O45420; -.
DR PRO; PR:O45420; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00009292; Expressed in embryo and 3 other cell types or tissues.
DR CDD; cd13281; PH_PLEKHD1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14383:SF1; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY D MEMBER 1; 1.
DR PANTHER; PTHR14383; SWAP-70 RECOMBINASE; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..570
FT /note="Pleckstrin homology domain-containing family D
FT member 1"
FT /id="PRO_0000349198"
FT DOMAIN 83..192
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 542..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 202..448
FT /evidence="ECO:0000255"
FT COMPBIAS 7..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 489..539
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_038217"
SQ SEQUENCE 570 AA; 66400 MW; D8A22F52F4A0D24D CRC64;
MTTKTTPKEL KAKKESKKKG SAPEPPKNGP PRTSPPNTIE KKGILRSLSF QFSNLTRKKG
NDYDLTPEEE GDGYGDEMGP VLGVQNYGIL MKKYKRKNRS ARWAKRFFVL KECFLIYYST
SYKKVFEKTR RIDLHPKGII PLIGCSIVSG GDVDKKNCLL IAHPQLPSAI IVAASDHQTQ
EMWLKALRSA TKISYKNTVV GETMIRELEN RGVLLNEEKK SYEERLEAEA KARKEEHDRA
DELAKDKEEL EAEREKLIRT TKKLKDDLQN VKNELKMTNE MKKTLEQEKM SLNSKTEHLQ
ANMESLNIEK EKIHEQLQEI VREREKVLID NQNLSTDKCQ LNNRLMEIET SRNCIMTEKE
KIENLLKMNE QKTQDLEKER QYYTMKTSEL MDHLKEVSEQ RDLTESELKE QMMARLGAEK
QLQAAEKALE HLEMALKMTG AQMTELQEHI MPDVHKLREF FEQCAEESRF EANRTGIMRN
AVYARKSIFD VAFSELDGHS LDVFEKFCEY NSQVLPVREK PQKLHKTWKQ SSFKRIGSIR
RSKRGIRSSF RKKTDSITTQ PREKEPLMQL
//
