ID   PLPHP_AQUAE             Reviewed;         228 AA.
AC   O66631;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
DE            Short=PLP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
GN   OrderedLocusNames=aq_274;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which is
CC       involved in PLP homeostasis. {ECO:0000255|HAMAP-Rule:MF_02087}.
CC   -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC       YggS/PROSC family. {ECO:0000255|HAMAP-Rule:MF_02087}.
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DR   EMBL; AE000657; AAC06592.1; -; Genomic_DNA.
DR   PIR; C70325; C70325.
DR   RefSeq; NP_213191.1; NC_000918.1.
DR   RefSeq; WP_010880129.1; NC_000918.1.
DR   AlphaFoldDB; O66631; -.
DR   SMR; O66631; -.
DR   STRING; 224324.aq_274; -.
DR   EnsemblBacteria; AAC06592; AAC06592; aq_274.
DR   KEGG; aae:aq_274; -.
DR   PATRIC; fig|224324.8.peg.228; -.
DR   eggNOG; COG0325; Bacteria.
DR   HOGENOM; CLU_059988_1_0_0; -.
DR   InParanoid; O66631; -.
DR   OrthoDB; 9804072at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   CDD; cd00635; PLPDE_III_YBL036c_like; 1.
DR   Gene3D; 3.20.20.10; Alanine racemase; 1.
DR   HAMAP; MF_02087; PLP_homeostasis; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   InterPro; IPR011078; PyrdxlP_homeostasis.
DR   NCBIfam; TIGR00044; YggS family pyridoxal phosphate-dependent enzyme; 1.
DR   PANTHER; PTHR10146; PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN; 1.
DR   PANTHER; PTHR10146:SF14; PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR   SUPFAM; SSF51419; PLP-binding barrel; 1.
DR   PROSITE; PS01211; UPF0001; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..228
FT                   /note="Pyridoxal phosphate homeostasis protein"
FT                   /id="PRO_0000163189"
FT   MOD_RES         35
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02087"
SQ   SEQUENCE   228 AA;  26339 MW;  94004EDB1A7F3338 CRC64;
     MNACERLSRV LERIQKACER AGRGENCAKL LGASKTVPPE VIREFYNCGL KVYGENRVQE
     FLKKYEALKD LDLEWHFIGR LQTNKVKYLM GKVVLIHSLD RKNLADEIQK RAFKNNIVQD
     VLIEVNVGGE ETKGGVEPEN LKELFEYTLE LPNVKVLGLM TIPPYLENPE DVRPYFRKLR
     ELRDELQREY NVALPHLSMG MSHDFEVAIE EGATIVRIGT LLFGERKY
//