ID PR8A7_RAT Reviewed; 240 AA.
AC P33578; P97786; Q4FZY5;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 08-NOV-2023, entry version 109.
DE RecName: Full=Prolactin-8A7;
DE AltName: Full=Growth hormone-related protein 1;
DE AltName: Full=Placental prolactin-like protein D;
DE Short=PLP-D;
DE Short=PRL-like protein D;
DE Flags: Precursor;
GN Name=Prl8a7; Synonyms=Prlpd;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Placenta;
RX PubMed=8756556; DOI=10.1210/endo.137.9.8756556;
RA Iwatsuki K., Shinozaki M., Hattori N., Hirasawa K., Itagaki S., Shiota K.,
RA Ogawa T.;
RT "Molecular cloning and characterization of a new member of the rat
RT placental prolactin (PRL) family, PRL-like protein D (PLP-D).";
RL Endocrinology 137:3849-3855(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 30-74.
RC TISSUE=Placenta;
RX PubMed=2351117; DOI=10.1210/endo-126-6-3271;
RA Ogilvie S., Buhi W.C., Olson J.A., Shiverick K.T.;
RT "Identification of a novel family of growth hormone-related proteins
RT secreted by rat placenta.";
RL Endocrinology 126:3271-3273(1990).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Placental basal zone cells.
CC -!- DEVELOPMENTAL STAGE: Mid to late gestation (gestation day 15).
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; AB000107; BAA19054.1; -; mRNA.
DR EMBL; BC098917; AAH98917.1; -; mRNA.
DR PIR; A60580; A60580.
DR RefSeq; NP_071982.1; NM_022537.1.
DR RefSeq; XP_006253971.1; XM_006253909.1.
DR AlphaFoldDB; P33578; -.
DR SMR; P33578; -.
DR STRING; 10116.ENSRNOP00000022797; -.
DR GlyCosmos; P33578; 1 site, No reported glycans.
DR GlyGen; P33578; 1 site.
DR PaxDb; 10116-ENSRNOP00000022797; -.
DR GeneID; 64368; -.
DR KEGG; rno:64368; -.
DR UCSC; RGD:620115; rat.
DR AGR; RGD:620115; -.
DR CTD; 64368; -.
DR RGD; 620115; Prl8a7.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR InParanoid; P33578; -.
DR OrthoDB; 4853101at2759; -.
DR PhylomeDB; P33578; -.
DR PRO; PR:P33578; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR CDD; cd10288; prolactin_like; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR PANTHER; PTHR11417:SF69; PROLACTIN-8A6-RELATED; 1.
DR PANTHER; PTHR11417; SOMATOTROPIN,PROLACTIN; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..240
FT /note="Prolactin-8A7"
FT /id="PRO_0000043397"
FT CARBOHYD 212
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 33..40
FT /evidence="ECO:0000255"
FT DISULFID 100..216
FT /evidence="ECO:0000250"
FT DISULFID 233..240
FT /evidence="ECO:0000250"
FT CONFLICT 66
FT /note="H -> W (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 27270 MW; EB672DF8F793EEAC CRC64;
MELPLSQHSF CKLLLLVVSS LLLWEKAASI PACLAEEGGC WNPLVETFNS AIHKAETLYD
LANQIHVELY QNKFSSEQFS SLNSQVIRKD KTALRAGSYC HSTLINTPNK ENEHINIEIK
EYVKTLINFV GAWISPLYHL VLELSAMQDV PESILSKAKE IEENNRQLLD DLKWILIKVS
PTEEMKEEFP SWGHLSFLKS SGEKSKFLAM FNLSNCLGYD AKYTLLNLRI LKCLTTGKDC
//
