ID PRTG_HUMAN Reviewed; 1150 AA.
AC Q2VWP7; Q8N7D8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 143.
DE RecName: Full=Protogenin;
DE AltName: Full=Protein Shen-Dan;
DE Flags: Precursor;
GN Name=PRTG {ECO:0000312|HGNC:HGNC:26373};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAU05741.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wong Y.-H., Chang C., Chen P.-H., Yu J.-Y., Wang Y.-C., Lee C.-M.,
RA Lin W.-J., Tsai T.-F., Wang A.-G., Fann M.-J.;
RT "Shen-Dan is a novel receptor for embryonic stem cells and developing
RT neurons.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAC05355.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 603-1150, AND VARIANT LEU-1062.
RC TISSUE=Testis {ECO:0000312|EMBL:BAC05355.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May play a role in anteroposterior axis elongation.
CC {ECO:0000250|UniProtKB:Q2EY15}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05355.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY630258; AAU05741.1; -; mRNA.
DR EMBL; AK098622; BAC05355.1; ALT_INIT; mRNA.
DR CCDS; CCDS42040.1; -.
DR RefSeq; NP_776175.2; NM_173814.5.
DR AlphaFoldDB; Q2VWP7; -.
DR SMR; Q2VWP7; -.
DR BioGRID; 129634; 10.
DR IntAct; Q2VWP7; 4.
DR MINT; Q2VWP7; -.
DR STRING; 9606.ENSP00000373937; -.
DR GlyCosmos; Q2VWP7; 4 sites, 1 glycan.
DR GlyGen; Q2VWP7; 5 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q2VWP7; -.
DR PhosphoSitePlus; Q2VWP7; -.
DR BioMuta; PRTG; -.
DR DMDM; 121946850; -.
DR EPD; Q2VWP7; -.
DR jPOST; Q2VWP7; -.
DR MassIVE; Q2VWP7; -.
DR PaxDb; 9606-ENSP00000373937; -.
DR PeptideAtlas; Q2VWP7; -.
DR ProteomicsDB; 61526; -.
DR Antibodypedia; 52034; 88 antibodies from 13 providers.
DR DNASU; 283659; -.
DR Ensembl; ENST00000389286.9; ENSP00000373937.4; ENSG00000166450.13.
DR GeneID; 283659; -.
DR KEGG; hsa:283659; -.
DR MANE-Select; ENST00000389286.9; ENSP00000373937.4; NM_173814.6; NP_776175.2.
DR UCSC; uc002adg.4; human.
DR AGR; HGNC:26373; -.
DR CTD; 283659; -.
DR DisGeNET; 283659; -.
DR GeneCards; PRTG; -.
DR HGNC; HGNC:26373; PRTG.
DR HPA; ENSG00000166450; Tissue enhanced (retina, thyroid gland).
DR MIM; 613261; gene.
DR neXtProt; NX_Q2VWP7; -.
DR OpenTargets; ENSG00000166450; -.
DR PharmGKB; PA142671124; -.
DR VEuPathDB; HostDB:ENSG00000166450; -.
DR eggNOG; KOG4221; Eukaryota.
DR GeneTree; ENSGT00940000155943; -.
DR HOGENOM; CLU_006906_1_0_1; -.
DR InParanoid; Q2VWP7; -.
DR OMA; MEDGYQA; -.
DR OrthoDB; 5397809at2759; -.
DR PhylomeDB; Q2VWP7; -.
DR TreeFam; TF321506; -.
DR PathwayCommons; Q2VWP7; -.
DR SignaLink; Q2VWP7; -.
DR BioGRID-ORCS; 283659; 14 hits in 1148 CRISPR screens.
DR ChiTaRS; PRTG; human.
DR GenomeRNAi; 283659; -.
DR Pharos; Q2VWP7; Tbio.
DR PRO; PR:Q2VWP7; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q2VWP7; Protein.
DR Bgee; ENSG00000166450; Expressed in buccal mucosa cell and 141 other cell types or tissues.
DR ExpressionAtlas; Q2VWP7; baseline and differential.
DR Genevisible; Q2VWP7; HS.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR CDD; cd00063; FN3; 5.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF53; BROTHER OF IHOG, ISOFORM G-RELATED; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 2: Evidence at transcript level;
KW Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..1150
FT /note="Protogenin"
FT /evidence="ECO:0000255"
FT /id="PRO_0000317047"
FT TOPO_DOM 36..949
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 950..970
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 971..1150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 36..130
FT /note="Ig-like 1"
FT /evidence="ECO:0000255"
FT DOMAIN 135..222
FT /note="Ig-like 2"
FT /evidence="ECO:0000255"
FT DOMAIN 235..322
FT /note="Ig-like 3"
FT /evidence="ECO:0000255"
FT DOMAIN 327..411
FT /note="Ig-like 4"
FT /evidence="ECO:0000255"
FT DOMAIN 421..515
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 517..613
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 618..717
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 724..817
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 822..917
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 981..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 488
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 630
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 60..113
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 156..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 256..304
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 348..395
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 236
FT /note="T -> A (in dbSNP:rs16976466)"
FT /id="VAR_049916"
FT VARIANT 826
FT /note="V -> L (in dbSNP:rs10518816)"
FT /id="VAR_049917"
FT VARIANT 1062
FT /note="I -> L (in dbSNP:rs1438914)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_038467"
SQ SEQUENCE 1150 AA; 127076 MW; F64CBA30C0F1EC89 CRC64;
MAPPLRPLAR LRPPGMLLRA LLLLLLLSPL PGVWCFSELS FVKEPQDVTV TRKDPVVLDC
QAHGEVPIKV TWLKNGAKMS ENKRIEVLSN GSLYISEVEG RRGEQSDEGF YQCLAMNKYG
AILSQKAHLA LSTISAFEVQ PISTEVHEGG VARFACKISS HPPAVITWEF NRTTLPMTMD
RITALPTGVL QIYDVSQRDS GNYRCIAATV AHRRKSMEAS LTVIPAKESK SFHTPTIIAG
PQNITTSLHQ TVVLECMATG NPKPIISWSR LDHKSIDVFN TRVLGNGNLM ISDVRLQHAG
VYVCRATTPG TRNFTVAMAT LTVLAPPSFV EWPESLTRPR AGTARFVCQA EGIPSPKMSW
LKNGRKIHSN GRIKMYNSKL VINQIIPEDD AIYQCMAENS QGSILSRARL TVVMSEDRPS
APYNVHAETM SSSAILLAWE RPLYNSDKVI AYSVHYMKAE GLNNEEYQVV IGNDTTHYII
DDLEPASNYT FYIVAYMPMG ASQMSDHVTQ NTLEDVPLRP PEISLTSRSP TDILISWLPI
PAKYRRGQVV LYRLSFRLST ENSIQVLELP GTTHEYLLEG LKPDSVYLVR ITAATRVGLG
ESSVWTSHRT PKATSVKAPK SPELHLEPLN CTTISVRWQQ DVEDTAAIQG YKLYYKEEGQ
QENGPIFLDT KDLLYTLSGL DPRRKYHVRL LAYNNIDDGY QADQTVSTPG CVSVRDRMVP
PPPPPHHLYA KANTSSSIFL HWRRPAFTAA QIINYTIRCN PVGLQNASLV LYLQTSETHM
LVQGLEPNTK YEFAVRLHVD QLSSPWSPVV YHSTLPEAPA GPPVGVKVTL IEDDTALVSW
KPPDGPETVV TRYTILYASR KAWIAGEWQV LHREGAITMA LLENLVAGNV YIVKISASNE
VGEGPFSNSV ELAVLPKETS ESNQRPKRLD SADAKVYSGY YHLDQKSMTG IAVGVGIALT
CILICVLILI YRSKARKSSA SKTAQNGTQQ LPRTSASLAS GNEVGKNLEG AVGNEESLMP
MIMPNSFIDA KGGTDLIINS YGPIIKNNSK KKWFFFQDSK KIQVEQPQRR FTPAVCFYQP
GTTVLISDED SPSSPGQTTS FSRPFGVAAD TEHSANSEGS HETGDSGRFS HESNDEIHLS
SVISTTPPNL
//
