ID PSG7_HUMAN Reviewed; 419 AA.
AC Q13046; A0A087WSZ1; Q15232;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 27-MAR-2024, entry version 174.
DE RecName: Full=Pregnancy-specific beta-1-glycoprotein 7;
DE Short=PS-beta-G-7;
DE Short=PSBG-7;
DE Short=Pregnancy-specific glycoprotein 7;
DE Flags: Precursor;
GN Name=PSG7 {ECO:0000312|HGNC:HGNC:9524};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=7794280; DOI=10.1006/bbrc.1995.1862;
RA Teglund S., Zhou G.Q., Hammarstroem S.;
RT "Characterization of cDNA encoding novel pregnancy-specific glycoprotein
RT variants.";
RL Biochem. Biophys. Res. Commun. 211:656-664(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-414.
RX PubMed=1690992; DOI=10.1016/0006-291x(90)92103-7;
RA Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H.,
RA Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D.,
RA Hardman N.;
RT "The human pregnancy-specific glycoprotein genes are tightly linked on the
RT long arm of chromosome 19 and are coordinately expressed.";
RL Biochem. Biophys. Res. Commun. 167:848-859(1990).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC pregnancy.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC {ECO:0000305}.
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DR EMBL; U18467; AAA75293.1; -; mRNA.
DR EMBL; AC005260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF454892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M32619; AAA60200.1; -; Genomic_DNA.
DR EMBL; M32617; AAA60200.1; JOINED; Genomic_DNA.
DR EMBL; M32618; AAA60200.1; JOINED; Genomic_DNA.
DR PIR; I83053; I83053.
DR PIR; JC4123; JC4123.
DR RefSeq; NP_002774.2; NM_002783.2.
DR AlphaFoldDB; Q13046; -.
DR SMR; Q13046; -.
DR BioGRID; 111651; 1.
DR GlyCosmos; Q13046; 7 sites, No reported glycans.
DR GlyGen; Q13046; 7 sites.
DR iPTMnet; Q13046; -.
DR PhosphoSitePlus; Q13046; -.
DR BioMuta; PSG7; -.
DR DMDM; 108935881; -.
DR MassIVE; Q13046; -.
DR PaxDb; 9606-ENSP00000421986; -.
DR PeptideAtlas; Q13046; -.
DR ProteomicsDB; 59122; -.
DR Antibodypedia; 21551; 67 antibodies from 9 providers.
DR DNASU; 5676; -.
DR Ensembl; ENST00000406070.7; ENSP00000421986.1; ENSG00000221878.13.
DR GeneID; 5676; -.
DR KEGG; hsa:5676; -.
DR MANE-Select; ENST00000406070.7; ENSP00000421986.1; NM_002783.3; NP_002774.2.
DR AGR; HGNC:9524; -.
DR CTD; 5676; -.
DR DisGeNET; 5676; -.
DR GeneCards; PSG7; -.
DR HGNC; HGNC:9524; PSG7.
DR HPA; ENSG00000221878; Group enriched (placenta, skin).
DR MIM; 176396; gene.
DR neXtProt; NX_Q13046; -.
DR OpenTargets; ENSG00000221878; -.
DR PharmGKB; PA33869; -.
DR VEuPathDB; HostDB:ENSG00000221878; -.
DR eggNOG; ENOG502RXPD; Eukaryota.
DR GeneTree; ENSGT01100000263479; -.
DR InParanoid; Q13046; -.
DR OrthoDB; 3033616at2759; -.
DR PathwayCommons; Q13046; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR BioGRID-ORCS; 5676; 6 hits in 189 CRISPR screens.
DR ChiTaRS; PSG7; human.
DR GenomeRNAi; 5676; -.
DR Pharos; Q13046; Tdark.
DR PRO; PR:Q13046; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q13046; Protein.
DR Bgee; ENSG00000221878; Expressed in placenta and 46 other cell types or tissues.
DR ExpressionAtlas; Q13046; baseline and differential.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; TAS:ProtInc.
DR GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd20948; IgC2_CEACAM5-like; 1.
DR CDD; cd05740; IgI_hCEACAM_2_4_6_like; 1.
DR CDD; cd05774; IgV_CEACAM_D1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44427; CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19; 1.
DR PANTHER; PTHR44427:SF19; PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 7-RELATED; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..419
FT /note="Pregnancy-specific beta-1-glycoprotein 7"
FT /id="PRO_0000014914"
FT DOMAIN 35..144
FT /note="Ig-like V-type"
FT DOMAIN 147..234
FT /note="Ig-like C2-type 1"
FT DOMAIN 240..327
FT /note="Ig-like C2-type 2"
FT DOMAIN 335..410
FT /note="Ig-like C2-type 3"
FT MOTIF 127..129
FT /note="Cell attachment site"
FT /evidence="ECO:0000255"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 303
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 169..217
FT /evidence="ECO:0000305"
FT DISULFID 262..310
FT /evidence="ECO:0000305"
FT DISULFID 354..394
FT /evidence="ECO:0000305"
FT VARIANT 65
FT /note="Y -> H (in dbSNP:rs7245978)"
FT /id="VAR_056075"
FT CONFLICT 83
FT /note="I -> V (in Ref. 1; AAA75293)"
FT /evidence="ECO:0000305"
FT CONFLICT 233..237
FT /note="LNLLP -> IIVPV (in Ref. 3; AAA60200)"
FT /evidence="ECO:0000305"
FT CONFLICT 348
FT /note="Q -> E (in Ref. 3; AAA60200)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 419 AA; 47027 MW; 57219C6FB683BF33 CRC64;
MGPLSAPPCT QHITWKGLLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ
NLTGYIWYKG QIRDLYHYVT SYIVDGQIIK YGPAYSGRET VYSNASLLIQ NVTQEDTGSY
TLHIIKRGDG TGGVTGRFTF TLYLETPKPS ISSSNFNPRE ATEAVILTCD PETPDASYLW
WMNGQSLPMT HSLQLSETNR TLYLFGVTNY TAGPYECEIR NPVSASRSDP VTLNLLPKLP
KPYITINNLN PRENKDVSTF TCEPKSENYT YIWWLNGQSL PVSPRVKRRI ENRILILPSV
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPRIYPS FTYYHSGQNL YLSCFADSNP
PAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSVT VRVSDWTLP
//
