ID PXA1_SCHPO Reviewed; 495 AA.
AC O14200; P78842;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE RecName: Full=PXA domain protein 1;
GN Name=pxa1; ORFNames=SPAC5D6.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 175-495.
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18256467; DOI=10.1271/bbb.70666;
RA Hosomi A., Kawanishi Y.Y., Tanaka N., Takegawa K.;
RT "PXA domain-containing protein Pxa1 is required for normal vacuole function
RT and morphology in Schizosaccharomyces pombe.";
RL Biosci. Biotechnol. Biochem. 72:548-556(2008).
CC -!- FUNCTION: Required for required for normal vacuolar morphology and for
CC vacuolar protein transport. Also required for endosome-to-Golgi protein
CC transport. {ECO:0000269|PubMed:18256467}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18256467};
CC Multi-pass membrane protein {ECO:0000269|PubMed:18256467}.
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DR EMBL; CU329670; CAB10855.1; -; Genomic_DNA.
DR EMBL; D89191; BAA13853.1; -; mRNA.
DR PIR; T38959; T38959.
DR PIR; T42750; T42750.
DR RefSeq; NP_593362.1; NM_001018794.2.
DR AlphaFoldDB; O14200; -.
DR SMR; O14200; -.
DR STRING; 284812.O14200; -.
DR iPTMnet; O14200; -.
DR MaxQB; O14200; -.
DR PaxDb; 4896-SPAC5D6-07c-1; -.
DR EnsemblFungi; SPAC5D6.07c.1; SPAC5D6.07c.1:pep; SPAC5D6.07c.
DR GeneID; 2541884; -.
DR KEGG; spo:SPAC5D6.07c; -.
DR PomBase; SPAC5D6.07c; pxa1.
DR VEuPathDB; FungiDB:SPAC5D6.07c; -.
DR eggNOG; ENOG502R9KS; Eukaryota.
DR HOGENOM; CLU_551142_0_0_1; -.
DR InParanoid; O14200; -.
DR OMA; KGASERW; -.
DR PRO; PR:O14200; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005768; C:endosome; IDA:PomBase.
DR GO; GO:0010008; C:endosome membrane; NAS:PomBase.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IMP:PomBase.
DR GO; GO:0008104; P:protein localization; IMP:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IMP:PomBase.
DR GO; GO:0007033; P:vacuole organization; IMP:PomBase.
DR InterPro; IPR003114; Phox_assoc.
DR PANTHER; PTHR22775:SF49; PX DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00313; PXA; 1.
DR PROSITE; PS51207; PXA; 1.
PE 2: Evidence at transcript level;
KW Endosome; Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..495
FT /note="PXA domain protein 1"
FT /id="PRO_0000116654"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..466
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..174
FT /note="PXA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00553"
FT REGION 402..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 292
FT /note="S -> A (in Ref. 2; BAA13853)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 495 AA; 56508 MW; 4DE89F93C1E40FA7 CRC64;
MAKLSSLLNP IISKILEIYV YSWYSGISKD ALFPSQCEQV GGSIVHELEK RLSRQDAMDL
LFYEIPFLLI KHIENTEEAK LRFALPQGQI LEIDTIYHSL HPHIALEKEE NELVYCRLLV
EDILKYLLPA TNSKSEIECV ILREALAVQI HKSIQVASSP ETMYKFIIYL SKAILQPSRR
PWKESITTAV RWVWHAFRIL LITRGVPYFS TAWFQFYLKL FSQKDNVSSS DLTRWFFFYT
LLYPWIALVS AFVAETMTLC CIVTIFYDKN VNRQWKQYIL TSVSNMDKGN PSGGSQSTNV
TTFRRFSQSS YPRRSNYRRR ISTSSKSLYE LSPSKFKSIP ITSNPPPMLN LSKGSTSVEP
TFCETNASVA LSTVTSTPVF STDSSPLSSR TRENLLSLIP SAVSSPTKAN TNKSHQRSFS
IPKATKDSQT PSENSAATLK QAAIDAYSQI PVIPFFLPSD KLIMLVESEY RNKHIFYSLL
NSFTMVMFPE LRHTK
//
