ID PXMP2_BOVIN Reviewed; 196 AA.
AC Q2KIY1;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 08-NOV-2023, entry version 98.
DE RecName: Full=Peroxisomal membrane protein 2;
GN Name=PXMP2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Seems to be involved in pore-forming activity and may
CC contribute to the unspecific permeability of the peroxisomal membrane.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PEX19 and SIVA1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC {ECO:0000305}.
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DR EMBL; BC112465; AAI12466.1; -; mRNA.
DR RefSeq; NP_001039473.1; NM_001046008.2.
DR AlphaFoldDB; Q2KIY1; -.
DR STRING; 9913.ENSBTAP00000009885; -.
DR PaxDb; 9913-ENSBTAP00000009885; -.
DR GeneID; 508609; -.
DR KEGG; bta:508609; -.
DR CTD; 5827; -.
DR eggNOG; KOG1944; Eukaryota.
DR HOGENOM; CLU_049109_7_1_1; -.
DR InParanoid; Q2KIY1; -.
DR OrthoDB; 1537at2759; -.
DR TreeFam; TF105311; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007248; Mpv17_PMP22.
DR PANTHER; PTHR11266:SF80; PEROXISOMAL MEMBRANE PROTEIN 2; 1.
DR PANTHER; PTHR11266; PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17; 1.
DR Pfam; PF04117; Mpv17_PMP22; 1.
PE 2: Evidence at transcript level;
KW Membrane; Peroxisome; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..196
FT /note="Peroxisomal membrane protein 2"
FT /id="PRO_0000245253"
FT TOPO_DOM 1..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..76
FT /note="Peroxisomal"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..174
FT /note="Peroxisomal"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..196
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 196 AA; 22259 MW; 661BEF198EA414E3 CRC64;
MAPAASKLRA EAGLGPLPRR ALSQYLRLLR LYPVLTKAAT SGILSALGNF LAQLIEKKQK
KENCSQKLDV SGPLRYAIYG FFFTGPLGHF FYLLMERWIP SEVPLAGIKR LLLDRLLFAP
AFLSLFFLVM NFLEGQDTAA FAAKMKSGFW PALRMNWRVW TPVQFININY IPVQFRVLFA
NLVALFWYAY LASLGK
//
